@article{Eiseler2007,
abstract = {Protein kinase D (PKD) has been implicated in the regulation of cell shape, adhesion, and migration. At the leading edge of migrating cells active PKD co-localizes with F-actin, Arp3 and cortactin. Platelet derived growth factor (PDGF) activates PKD and recruits the kinase to the leading edge, suggesting a role for PKD in actin remodelling. In support of this, PKD directly interacts with F-actin and phosphorylates cortactin in vitro. Interference with PKD function by overexpression of a dominant negative PKD or by PKD-specific siRNA enhanced cell migration, whereas cells overexpressing PKD wild type displayed reduced migratory potential. Taken together, these data reveal a negative regulatory function of PKD in cell migration. {\textcopyright} 2007 Federation of European Biochemical Societies.},
added-at = {2018-02-01T16:02:53.000+0100},
annote = {Eiseler, TimSchmid, Michael ATopbas, FitnatPfizenmaier, KlausHausser, AngelikaengResearch Support, Non-U.S. Gov'tEnglandFEBS Lett. 2007 Sep 4;581(22):4279-87. doi: 10.1016/j.febslet.2007.07.079. Epub 2007 Aug 10.},
author = {Eiseler, Tim and Schmid, Michael A. and Topbas, Fitnat and Pfizenmaier, Klaus and Hausser, Angelika},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2ee14d3a1862f9d0be1bf8b95e06fcde1/cristiano},
doi = {10.1016/j.febslet.2007.07.079},
edition = {2007/08/21},
interhash = {2a14426ea713a0dcfa2b60b429ce51b1},
intrahash = {ee14d3a1862f9d0be1bf8b95e06fcde1},
isbn = {0014-5793 (Print)$\backslash$r0014-5793 (Linking)},
issn = {00145793},
journal = {FEBS Letters},
keywords = {2007 hausser izi pfizenmaier},
number = 22,
pages = {4279--4287},
pmid = {17707375},
timestamp = {2018-07-25T12:31:54.000+0200},
title = {{PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration}},
url = {https://www.ncbi.nlm.nih.gov/pubmed/17707375},
volume = 581,
year = 2007
}