%0 Journal Article %1 noauthororeditor %A Christian, Rode %A Andre, Tomalka %A R., Blickhan %A Tobias, Siebert %D 2023 %J Biophys. Journal 1 %K PN2-8 actin biologie fibre muscle myosin myown physiology sceletal structure titin %N 17 %P 3541-3543 %R 10.1016/j.bpj.2023.05.026 %T Structurally motivated models to explain the muscle’s force-length relationship %U https://www.sciencedirect.com/science/article/abs/pii/S0006349523003387?via%3Dihub %V 122 %X Section snippets The Rode model's explanation of the FLR's ascending limb allegedly involves pushing forces in thin filaments The main Rockenfeller et al. argument to dismiss the Rode model is the wrong assertion that the Rode model describes the FLR’s ascending limb based on pushing or compressive forces in thin filaments. The thin filaments would be too soft to transmit relevant pushing forces. However, in the Rode model, thin filaments are always pulled away from the Z-disk. Furthermore, Rockenfeller et al. wrongly assert that swXBs generate pushing forces on thin filaments in the Rode model and that the The Rockenfeller model ignores geometrical changes developing on the FLR’s ascending limb The Rockenfeller model assumes a hexagonal filament lattice as in optimal overlap down to 0.4-μm half-sarcomere length (with about 1 μm being the optimal length) and that the lattice distances progressively increase with shortening due to volume constancy. These assumptions ignore several geometrical changes in the half-sarcomere that occur during shortening and hamper the predictive power of the model in the range of the FLR’s ascending limb. For example, the Rockenfeller model predicts noThe Rockenfeller model assumes effective force in the region of double thin-filament overlap Double thin-filament overlap starts to develop when thin filaments slide through the M-line near optimal half-sarcomere length (left-hand side of the FLR plateau). The Rockenfeller model assumes that XBs are formed in the region of double thin-filament overlap. This assumption leads to effective force in this region and cannot explain Trombitás and Tigyi-Sebes’ experiments (8). Trombitás and Tigyi-Sebes stretched rigor muscle fibers leading to the detachment of thin filaments from the Z-disk. The Rockenfeller model's effective overlap function is mechanically inconsistent on the FLR's ascending limb One basis of the Rockenfeller model’s force calculation is the effective filament overlap, the theoretical capacity to produce isometric force depending on half-sarcomere length without effects of interfilament spacing. Surprisingly, the effective filament overlap (their Figure 1 in (3)) is straight at about 0.8-μm half-sarcomere length. First, when thick-filament tips slide through the Z-disk at this length, the myosin heads meet thin filaments of opposite polarity and form swXBs in their

@article{noauthororeditor, abstract = {Section snippets The Rode model's explanation of the FLR's ascending limb allegedly involves pushing forces in thin filaments The main Rockenfeller et al. argument to dismiss the Rode model is the wrong assertion that the Rode model describes the FLR’s ascending limb based on pushing or compressive forces in thin filaments. The thin filaments would be too soft to transmit relevant pushing forces. However, in the Rode model, thin filaments are always pulled away from the Z-disk. Furthermore, Rockenfeller et al. wrongly assert that swXBs generate pushing forces on thin filaments in the Rode model and that the The Rockenfeller model ignores geometrical changes developing on the FLR’s ascending limb The Rockenfeller model assumes a hexagonal filament lattice as in optimal overlap down to 0.4-μm half-sarcomere length (with about 1 μm being the optimal length) and that the lattice distances progressively increase with shortening due to volume constancy. These assumptions ignore several geometrical changes in the half-sarcomere that occur during shortening and hamper the predictive power of the model in the range of the FLR’s ascending limb. For example, the Rockenfeller model predicts noThe Rockenfeller model assumes effective force in the region of double thin-filament overlap Double thin-filament overlap starts to develop when thin filaments slide through the M-line near optimal half-sarcomere length (left-hand side of the FLR plateau). The Rockenfeller model assumes that XBs are formed in the region of double thin-filament overlap. This assumption leads to effective force in this region and cannot explain Trombitás and Tigyi-Sebes’ experiments (8). Trombitás and Tigyi-Sebes stretched rigor muscle fibers leading to the detachment of thin filaments from the Z-disk. The Rockenfeller model's effective overlap function is mechanically inconsistent on the FLR's ascending limb One basis of the Rockenfeller model’s force calculation is the effective filament overlap, the theoretical capacity to produce isometric force depending on half-sarcomere length without effects of interfilament spacing. Surprisingly, the effective filament overlap (their Figure 1 in (3)) is straight at about 0.8-μm half-sarcomere length. First, when thick-filament tips slide through the Z-disk at this length, the myosin heads meet thin filaments of opposite polarity and form swXBs in their}, added-at = {2023-11-20T14:42:45.000+0100}, author = {Christian, Rode and Andre, Tomalka and R., Blickhan and Tobias, Siebert}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/232079559e33f1e8958126981cee1b324/inspo5}, doi = {10.1016/j.bpj.2023.05.026}, interhash = {bd00323910b3bdf30e8ce2268da8c50c}, intrahash = {32079559e33f1e8958126981cee1b324}, journal = {Biophys. Journal 1}, keywords = {PN2-8 actin biologie fibre muscle myosin myown physiology sceletal structure titin}, language = {English}, month = {september 2023}, number = 17, pages = {3541-3543}, timestamp = {2023-12-01T17:12:16.000+0100}, title = {Structurally motivated models to explain the muscle’s force-length relationship}, url = {https://www.sciencedirect.com/science/article/abs/pii/S0006349523003387?via%3Dihub}, volume = 122, year = 2023 }