DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling.. Journal of cell science, (122)Pt 1:92--102, 2009. [PUMA: 2008 hausser izi olayioye] URL
Response to bistability in apoptosis: Roles of Bax, Bcl-2, and mitochondrial permeability transition pores. Biophysical Journal, (92)9:3332--3334, 2007. [PUMA: 2007 izi scheuric] URL
The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Experimental Cell Research, (317)4:496--503, 2011. [PUMA: 2011 hausser izi olayioye] URL
Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene, (30)5:575--587, 2011. [PUMA: 2011 izi] URL
Investigation of salt properties with electro-acoustic measurements and their effect on dynamic binding capacity in hydrophobic interaction chromatography. Journal of Chromatography A, (1177)2:215--225, 2008. [PUMA: 2008 izi] URL
Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III β protects from dephosphorylation and stabilizes lipid kinase activity. Journal of Cell Science, (119)17:3613--3621, 2006. [PUMA: 2006 hausser izi pfizenmaier] URL
Antibody targeting of nanoparticles to tumor-specific receptors: immunoliposomes.. Methods in molecular biology (Clifton, N.J.), (624):295--308, 2010. [PUMA: 2010 izi kontermann] URL
Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. Journal of Biological Chemistry, (284)38:25612--25619, 2009. [PUMA: 2009 izi kontermann] URL
Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation.. EURASIP journal on bioinformatics & systems biology, (2011)1:3, 2011. [PUMA: 2011 izi kulms sauter] URL
Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. Journal of Biological Chemistry, (282)31:22492--22498, 2007. [PUMA: 2007 izi olayioye] URL
Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. Gene Expression Patterns, (6)8:849--856, 2006. [PUMA: 2006 hausser izi] URL
The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Engineering, Design and Selection, (23)11:827--834, 2010. [PUMA: 2010 izi kontermann mueller] URL
Genetic engineering of death ligands for improvement of therapeutic activity. Advances in Experimental Medicine and Biology, (691):507--519, 2011. [PUMA: 2011 izi pfizenmaier] URL
Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug. Cell Death and Differentiation, (13)2:273--284, 2006. [PUMA: 2006 izi mueller pfizenmaier] URL
Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization. FEBS Journal, (275)9:2296--2304, 2008. [PUMA: 2008 izi pfizenmaier] URL
Mechanism of PP2A-mediated IKKβ dephosphorylation: A systems biological approach. BMC Systems Biology, (3):71, 2009. [PUMA: 2009 izi kulms sauter] URL
Single-Chain TNF, a TNF Derivative with Enhanced Stability and Antitumoral Activity. The Journal of Immunology, (180)12:8176--8183, 2008. [PUMA: 2008 izi pfizenmaier] URL
Off-target analysis of control siRNA molecules reveals important differences in the cytokine profile and inflammation response of human fibroblasts.. Oligonucleotides, (20)1:17--26, 2010. [PUMA: 2010 izi kontermann] URL
Engineering death receptor ligands for cancer therapy. Cancer Letters, (332)2:163--174, 2013. [PUMA: 2013 izi pfizenmaier] URL
A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispecific single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Engineering, Design and Selection, (20)11:569--576, 2007. [PUMA: 2007 izi kontermann] URL
Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein. Journal of Cell Biology, (178)1:15--22, 2007. [PUMA: 2007 hausser izi olayioye pfizenmaier] URL
Expression patterns of protein kinase D 3 during mouse development. BMC Developmental Biology, (8):47, 2008. [PUMA: 2008 hausser izi pfizenmaier] URL
Cell selection and characterization of a novel human endothelial cell specific nanobody. Molecular Immunology, (46)8-9:1814--1823, 2009. [PUMA: 2009 izi kontermann] URL
Recombinant bispecific antibodies for cellular cancer immunotherapy. Current opinion in molecular therapeutics, (9)4:319, 2007. [PUMA: 2007 izi kontermann mueller] URL
A novel protein kinase D phosphorylation site in the tumor suppressor Rab interactor 1 is critical for coordination of cell migration. Molecular Biology of the Cell, (22)5:570--580, 2011. [PUMA: 2011 hausser izi] URL
Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons.. Molecular biology of the cell, (20)7:2108--20, 2009. [PUMA: 2009 hausser izi pfizenmaier] URL
Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs, (23)2:93--109, 2009. [PUMA: 2009 izi kontermann] URL
Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP. Oncogene, (28)3:345--362, 2009. [PUMA: 2009 izi kulms] URL
Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution. EMBO Journal, (27)10:1423--1435, 2008. [PUMA: 2008 hausser izi] URL
Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family. Adv Exp Med Biol, (691):487--491, 2011. [PUMA: 2011 izi pfizenmaier] URL
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin. Journal of Biological Chemistry, (285)24:18672--18683, 2010. [PUMA: 2010 hausser izi pfizenmaier] URL
Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFκB activation via Src-dependent blockade of PP2A. Biochemical Pharmacology, (80)4:439--447, 2010. [PUMA: 2010 izi kulms] URL
Self-interaction of Abutilon mosaic virus replication initiator protein (Rep) in plant cell nuclei. Virus Research, (161)2:194--197, 2011. [PUMA: 2011 izi] URL
Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins. Cell Death and Disease, (1)8:e68, 2010. [PUMA: 2010 izi pfizenmaier] URL
Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy. Arteriosclerosis, Thrombosis, and Vascular Biology, (27)11:2355--2362, 2007. [PUMA: 2007 hausser izi pfizenmaier] URL
Nanoscale arrangement of apoptotic ligands reveals a demand for a minimal lateral distance for efficient death receptor activation. Nano Letters, (9)12:4240--4245, 2009. [PUMA: 2009 izi scheuric] URL
Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. Oncogene, (28)15:1769--1781, 2009. [PUMA: 2009 izi scheuric] URL
Identification of PP2A as a crucial regulator of the NF-$\kappa$B feedback loop: Its inhibition by UVB turns NF-κB into a pro-apoptotic factor. Cell Death and Differentiation, (15)11:1681--1690, 2008. [PUMA: 2008 izi kulms] URL
Ligand-induced internalization of TNF receptor 2 mediated by a di-leucin motif is dispensable for activation of the NFκB pathway. Cellular Signalling, (23)1:161--170, 2011. [PUMA: 2011 izi pfizenmaier] URL
TNFR1-induced activation of the classical NF-κB pathway. FEBS Journal, (278)6:862--876, 2011. [PUMA: 2011 izi scheuric] URL
DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain.. Molecular biology of the cell, (20)20:4400--4411, 2009. [PUMA: 2009 izi olayioye] URL
SLy2 targets the nuclear SAP30/HDAC1 complex. International Journal of Biochemistry and Cell Biology, (42)9:1472--1481, 2010. [PUMA: 2010 hausser izi] URL
Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70). Molecular Biotechnology, (46)3:265--278, 2010. [PUMA: 2010 izi kontermann] URL
Fluorescence correlation spectroscopy reveals topological segregation of the two tumor necrosis factor membrane receptors. Biochimica et Biophysica Acta - Biomembranes, (1798)6:1081--1089, 2010. [PUMA: 2010 izi scheuric] URL
Tropism Modification of Adenovirus Vectors by Peptide Ligand Insertion into Various Positions of the Adenovirus Serotype 41 Short-Fiber Knob Domain. Journal of Virology, (81)6:2688--2699, 2007. [PUMA: 2007 izi kontermann] URL
Protein kinase D controls voluntary-running-induced skeletal muscle remodelling. Biochemical Journal, (440)3:327--324, 2011. [PUMA: 2011 hausser izi pfizenmaier] URL
Deleted in liver cancer 1 controls cell migration through a dia1-dependent signaling pathway. Cancer Research, (68)21:8743--8751, 2008. [PUMA: 2008 izi olayioye] URL
Therapeutic Targeting of CD95 and the TRAIL Death Receptors. Recent Patents on Anti-Cancer Drug Discovery, (6)3:294--310, 2011. [PUMA: 2011 izi pfizenmaier] URL
Dual function of cysteine rich domain (CRD) 1 of TNF receptor type 1: Conformational stabilization of CRD2 and control of receptor responsiveness. Cellular Signalling, (22)3:404--414, 2010. [PUMA: 2010 izi scheuric] URL
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. Journal of Biological Chemistry, (283)21:14590--14599, 2008. [PUMA: 2008 hausser izi pfizenmaier] URL
Phosphorylation of ser 402 impedes phosphatase activity of slingshot 1. EMBO Reports, (12)6:527--533, 2011. [PUMA: 2011 hausser izi] URL
A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. PLoS ONE, (6)11:e27621, 2011. [PUMA: 2011 izi pfizenmaier] URL
Aldehyde PEGylation kinetics: A standard protein versus a pharmaceutically relevant single chain variable fragment. Bioconjugate Chemistry, (22)8:1545--1558, 2011. [PUMA: 2011 boettinger izi] URL
Improved pharmacokinetics of recombinant bispecific antibody molecules by fusion to human serum albumin. Journal of Biological Chemistry, (282)17:12650--12660, 2007. [PUMA: 2007 izi kontermann mueller] URL
Multi-level control of actin dynamics by protein kinase D. Cellular Signalling, (25)9:1739--1747, September 2013. [PUMA: 2013 hausser izi olayioye] URL
Evaluating combinations of costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy. Cancer Immunology, Immunotherapy, (62)8:1369--1380, August 2013. [PUMA: 2013 izi kontermann] URL
Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing. Cell Death and Disease, (4)7:e719--e719, Juli 2013. [PUMA: 2013 izi kulms] URL
Antagonistic TNF receptor one-specific antibody (ATROSAB): Receptor binding and in vitro bioactivity. In Gernot Zissel (Hrsg.), PLoS ONE, (8)8:e72156, August 2013. [PUMA: 2013 izi kontermann pfizenmaier] URL
An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action. Protein Engineering, Design and Selection, (26)10:581--587, Oktober 2013. [PUMA: 2013 izi kontermann pfizenmaier] URL
TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress. Biochemical and Biophysical Research Communications, (440)2:336--341, Oktober 2013. [PUMA: 2013 izi pfizenmaier] URL
Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells. Metabolic Engineering, (20):157--166, November 2013. [PUMA: 2013 hausser izi olayioye] URL
Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology, (57)2:625--636, Februar 2013. [PUMA: 2013 izi kontermann pfizenmaier] URL
Combining Antibody-Directed Presentation of IL-15 and 4-1BBL in a Trifunctional Fusion Protein for Cancer Immunotherapy. Molecular Cancer Therapeutics, (13)1:112--121, Januar 2014. [PUMA: 2014 izi kontermann mueller] URL
A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor. Protein Engineering, Design and Selection, (27)10:331--337, Oktober 2014. [PUMA: 2014 izi kontermann] URL
A WXW Motif Is Required for the Anticancer Activity of the TAT-RasGAP317–326 Peptide. Journal of Biological Chemistry, (289)34:23701--23711, August 2014. [PUMA: 2014 izi olayioye] URL
MiR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion. Cancer Research, (74)18:5256--5265, September 2014. [PUMA: 2014 izi olayioye] URL
EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. In John Souglakos (Hrsg.), PLoS ONE, (9)9:e107165, September 2014. [PUMA: 2014 izi kontermann olayioye pfizenmaier] URL
Dominant negative effects of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by Formation of heteromeric complexes. Journal of Biological Chemistry, (289)23:16576--16587, Juni 2014. [PUMA: 2014 izi scheuric] URL
Identification of New IκBα Complexes by an Iterative Experimental and Mathematical Modeling Approach. In Feilim Mac Gabhann (Hrsg.), PLoS Computational Biology, (10)3:e1003528, März 2014. [PUMA: 2014 izi kulms] URL
In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes. Journal of Controlled Release, (186):1--10, Juli 2014. [PUMA: 2014 izi kontermann] URL
Tumor-antigen-binding bispecific antibodies for cancer treatment. Seminars in Oncology, (41)5:653--660, Oktober 2014. [PUMA: 2014 izi kontermann] URL
Immuno-LipoTRAIL: Targeted delivery of TRAIL-functionalized liposomal nanoparticles. Bioconjugate Chemistry, (25)5:879--887, Mai 2014. [PUMA: 2014 izi kontermann pfizenmaier] URL
Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. International Journal of Cancer, (136)9:2228--2240, Mai 2015. [PUMA: 2015 izi kontermann] URL
Expression and Purification of Recombinant Antibody Formats and Antibody Fusion Proteins. Methods in molecular biology (Clifton, N.J.), (1131):273--295, 2014. [PUMA: 2014 izi kontermann] URL
Characterization of the biological anti-staphylococcal functionality of hUK-66 IgG1, ahumanized monoclonal antibody as substantial component for an immunotherapeutic approach. Human Vaccines and Immunotherapeutics, (10)4:926--937, 2014. [PUMA: 2014 izi kontermann] URL
Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis. In Ralf Andreas Linker (Hrsg.), PLoS ONE, (9)2:e90117, Februar 2014. [PUMA: 2014 izi pfizenmaier] URL
Elevated protein kinase D3 (PKD3) expression supports proliferation of Triple-negative breast cancer cells and contributes to mTORC1-S6K1 pathway activation. Journal of Biological Chemistry, (289)6:3138--3147, Februar 2014. [PUMA: 2014 hausser izi olayioye] URL
Functional cross-talk between ras and rho pathways: A ras-specific gtpase-activating protein (p120RasGAP) competitively inhibits the rhogap activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, (289)10:6839--6849, März 2014. [PUMA: 2014 izi olayioye] URL
Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.. Molecular biology of the cell, (25)3:324--36, Februar 2014. [PUMA: 2014 izi pfizenmaier] URL
Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties. Molecular Cancer Therapeutics, (13)1:101--111, Januar 2014. [PUMA: 2014 izi kontermann pfizenmaier] URL
A mouse bone marrow stromal cell line with skeletal stem cell characteristics to study osteogenesis in vitro and in vivo.. Stem cells and development, (23)10:1097--108, Mai 2014. [PUMA: 2014 hausser izi pfizenmaier] URL
Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor. Glia, (62)2:272--283, Februar 2014. [PUMA: 2014 izi kontermann pfizenmaier] URL
Immunoliposomes for Targeted Delivery of an Antifibrotic Drug. Molecular Pharmaceutics, (12)9:3146--3157, September 2015. [PUMA: 2015 izi kontermann] URL
Antibody fusions with immunomodulatory proteins for cancer therapy. Pharmacology and Therapeutics, (154):57--66, Oktober 2015. [PUMA: 2015 izi mueller] URL
Mitotic Golgi translocation of ERK1c is mediated by PI4KIIIβ/14-3-3γ shuttling complex.. Journal of cell science, (204)22:jcs.170910--, November 2015. [PUMA: 2015 hausser izi] URL
Interrelation of oxidative stress and inflammation in neurodegenerative disease: Role of TNF. Oxidative Medicine and Cellular Longevity, (2015):1--18, 2015. [PUMA: 2015 fischer izi maier] URL
A fab-selective immunoglobulin-binding domain from streptococcal protein G with improved half-life extension properties. In Serge Muyldermans (Hrsg.), PLoS ONE, (10)10:e0139838, Oktober 2015. [PUMA: 2015 izi kontermann] URL
Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation. Journal of Cell Biology, (210)5:771--783, August 2015. [PUMA: 2015 hausser izi pfizenmaier] URL
The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking. Journal of Cell Science, (128)7:1386--1399, April 2015. [PUMA: 2015 hausser izi olayioye] URL
Bispecific antibodies. Drug Discovery Today, (20)7:838--847, Juli 2015. [PUMA: 2015 izi kontermann] URL
A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Systems Biology, (9)1:9, Februar 2015. [PUMA: 2015 hausser izi olayioye] URL
A new tool for the quantitative analysis of dendritic filopodial motility. Cytometry Part A, (87)1:89--96, Januar 2015. [PUMA: 2015 hausser izi pfizenmaier] URL
Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy. Antibodies, (4)1:48--70, Multidisciplinary Digital Publishing Institute, März 2015. [PUMA: 2015 izi kontermann] URL
Rho regulation: DLC proteins in space and time. Cellular Signalling, (27)8:1643--1651, August 2015. [PUMA: 2015 izi olayioye] URL
Tailoring the stealth properties of biocompatible polysaccharide nanocontainers. Biomaterials, (49):125--134, Elsevier, Mai 2015. [PUMA: 2015 izi kontermann pfizenmaier] URL
Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously. Journal of Controlled Release, (201):56--67, März 2015. [PUMA: 2015 izi kontermann] URL
B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Research, (75)1:216--229, Januar 2015. [PUMA: 2015 izi olayioye] URL
Selective blocking of TNF receptor 1 attenuates peritoneal dialysis fluid induced inflammation of the peritoneum in mice. In Gautam Sethi (Hrsg.), PLoS ONE, (11)10:e0163314, Oktober 2016. [PUMA: 2016 izi pfizenmaier] URL
Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints. BMC Systems Biology, (10)1:80, Dezember 2016. [PUMA: 2016 hausser izi] URL
Bcl-2-Ome-a database and interactive web service for dissecting the Bcl-2 interactome. Cell Death and Differentiation, (24)1:192, Nature Publishing Group, Januar 2017. [PUMA: 2017 izi morrison] URL