It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NFkappaB and JNK. Here, we show that TRAF1 inhibits TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced activation of NFkappaB from the inhibitory effect of TNFR2. TRAF1 co-recruited with TRAF2 to both TNF receptors. Despite lacking an amino-terminal RING/zinc-finger domain, TRAF1 did not interfere with TNFR1-induced activation of JNK and NFkappaB. It is noted that physiological expression levels of TRAF1 enhanced NFkappaB activation and interleukin-8 (IL8) production induced by TNFR2. Thus, TRAF1 shifts the quality of integrated TNFR1-TNFR2 signaling from apoptosis induction to proinflammatory NFkappaB signaling.
%0 Journal Article
%1 Wicovsky2009
%A Wicovsky, A.
%A Henkler, F.
%A Salzmann, S.
%A Scheurich, P.
%A Kneitz, C.
%A Wajant, H.
%D 2009
%J Oncogene
%K 2009 izi scheuric
%N 15
%P 1769--1781
%R 10.1038/onc.2009.29
%T Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation
%U https://www.ncbi.nlm.nih.gov/pubmed/19287455
%V 28
%X It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NFkappaB and JNK. Here, we show that TRAF1 inhibits TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced activation of NFkappaB from the inhibitory effect of TNFR2. TRAF1 co-recruited with TRAF2 to both TNF receptors. Despite lacking an amino-terminal RING/zinc-finger domain, TRAF1 did not interfere with TNFR1-induced activation of JNK and NFkappaB. It is noted that physiological expression levels of TRAF1 enhanced NFkappaB activation and interleukin-8 (IL8) production induced by TNFR2. Thus, TRAF1 shifts the quality of integrated TNFR1-TNFR2 signaling from apoptosis induction to proinflammatory NFkappaB signaling.
%7 2009/03/17
%@ 1476-5594
@article{Wicovsky2009,
abstract = {It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1-induced activation of NFkappaB and JNK. Here, we show that TRAF1 inhibits TNFR2-induced proteasomal degradation of TRAF2 and relieves TNFR1-induced activation of NFkappaB from the inhibitory effect of TNFR2. TRAF1 co-recruited with TRAF2 to both TNF receptors. Despite lacking an amino-terminal RING/zinc-finger domain, TRAF1 did not interfere with TNFR1-induced activation of JNK and NFkappaB. It is noted that physiological expression levels of TRAF1 enhanced NFkappaB activation and interleukin-8 (IL8) production induced by TNFR2. Thus, TRAF1 shifts the quality of integrated TNFR1-TNFR2 signaling from apoptosis induction to proinflammatory NFkappaB signaling.},
added-at = {2018-02-01T15:23:05.000+0100},
author = {Wicovsky, A. and Henkler, F. and Salzmann, S. and Scheurich, P. and Kneitz, C. and Wajant, H.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/25a1e019c89adfc15d31fc58663042d1a/cristiano},
doi = {10.1038/onc.2009.29},
edition = {2009/03/17},
interhash = {8d5122a4d5c4041ae294d65687d1840b},
intrahash = {5a1e019c89adfc15d31fc58663042d1a},
isbn = {1476-5594},
issn = {09509232},
journal = {Oncogene},
keywords = {2009 izi scheuric},
number = 15,
pages = {1769--1781},
pmid = {19287455},
timestamp = {2018-07-25T12:32:22.000+0200},
title = {{Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation}},
url = {https://www.ncbi.nlm.nih.gov/pubmed/19287455},
volume = 28,
year = 2009
}
