Fundamental development of a biocompatible and degradable nanocarrier platform based on hydroxyethyl starch (HES) is reported. HES is a derivative of starch and possesses both high biocompatibility and improved stability against enzymatic degradation; it is used to prepare nanocapsules via the polyaddition reaction at the interface of water nanodroplets dispersed in an organic miniemulsion. The synthesized hollow nanocapsules can be loaded with hydrophilic guests in its aqueous core, tuned in size, chemically functionalized in various pathways, and show high shelf life stability. The surface of the HES nanocapsules is further functionalized with poly(ethylene glycol) via different chemistries, which substantially enhanced blood half-life time. Importantly, methods for precise and reliable quantification of the degree of functionalization are also introduced, which enable the precise control of the chemistry on the capsules' surface. The stealth properties of these capsules is studied both in-vitro and in-vivo. The functionalized nanocapsules serve as a modular platform for specific cell targeting, as they show no unspecific up-taken by different cell types and show very long circulating time in blood (up to 72h).
%0 Journal Article
%1 Kang2015
%A Kang, Biao
%A Okwieka, Patricia
%A Schöttler, Susanne
%A Seifert, Oliver
%A Kontermann, Roland E.
%A Pfizenmaier, Klaus
%A Musyanovych, Anna
%A Meyer, Ralf
%A Diken, Mustafa
%A Sahin, Ugur
%A Mailänder, Volker
%A Wurm, Frederik R.
%A Landfester, Katharina
%D 2015
%I Elsevier
%J Biomaterials
%K 2015 izi kontermann pfizenmaier
%P 125--134
%R 10.1016/j.biomaterials.2015.01.042
%T Tailoring the stealth properties of biocompatible polysaccharide nanocontainers
%U https://www.sciencedirect.com/science/article/pii/S0142961215000599
%V 49
%X Fundamental development of a biocompatible and degradable nanocarrier platform based on hydroxyethyl starch (HES) is reported. HES is a derivative of starch and possesses both high biocompatibility and improved stability against enzymatic degradation; it is used to prepare nanocapsules via the polyaddition reaction at the interface of water nanodroplets dispersed in an organic miniemulsion. The synthesized hollow nanocapsules can be loaded with hydrophilic guests in its aqueous core, tuned in size, chemically functionalized in various pathways, and show high shelf life stability. The surface of the HES nanocapsules is further functionalized with poly(ethylene glycol) via different chemistries, which substantially enhanced blood half-life time. Importantly, methods for precise and reliable quantification of the degree of functionalization are also introduced, which enable the precise control of the chemistry on the capsules' surface. The stealth properties of these capsules is studied both in-vitro and in-vivo. The functionalized nanocapsules serve as a modular platform for specific cell targeting, as they show no unspecific up-taken by different cell types and show very long circulating time in blood (up to 72h).
%@ 0142-9612
@article{Kang2015,
abstract = {Fundamental development of a biocompatible and degradable nanocarrier platform based on hydroxyethyl starch (HES) is reported. HES is a derivative of starch and possesses both high biocompatibility and improved stability against enzymatic degradation; it is used to prepare nanocapsules via the polyaddition reaction at the interface of water nanodroplets dispersed in an organic miniemulsion. The synthesized hollow nanocapsules can be loaded with hydrophilic guests in its aqueous core, tuned in size, chemically functionalized in various pathways, and show high shelf life stability. The surface of the HES nanocapsules is further functionalized with poly(ethylene glycol) via different chemistries, which substantially enhanced blood half-life time. Importantly, methods for precise and reliable quantification of the degree of functionalization are also introduced, which enable the precise control of the chemistry on the capsules' surface. The stealth properties of these capsules is studied both in-vitro and in-vivo. The functionalized nanocapsules serve as a modular platform for specific cell targeting, as they show no unspecific up-taken by different cell types and show very long circulating time in blood (up to 72h).},
added-at = {2018-02-01T14:35:36.000+0100},
author = {Kang, Biao and Okwieka, Patricia and Sch{\"{o}}ttler, Susanne and Seifert, Oliver and Kontermann, Roland E. and Pfizenmaier, Klaus and Musyanovych, Anna and Meyer, Ralf and Diken, Mustafa and Sahin, Ugur and Mail{\"{a}}nder, Volker and Wurm, Frederik R. and Landfester, Katharina},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/285ac3ab127ead121f322b364de6176fc/cristiano},
doi = {10.1016/j.biomaterials.2015.01.042},
interhash = {3e3813e0305a994ec2bd00214994ac6d},
intrahash = {85ac3ab127ead121f322b364de6176fc},
isbn = {0142-9612},
issn = {18785905},
journal = {Biomaterials},
keywords = {2015 izi kontermann pfizenmaier},
month = may,
pages = {125--134},
pmid = {25725561},
publisher = {Elsevier},
timestamp = {2018-07-25T12:24:13.000+0200},
title = {{Tailoring the stealth properties of biocompatible polysaccharide nanocontainers}},
url = {https://www.sciencedirect.com/science/article/pii/S0142961215000599},
volume = 49,
year = 2015
}
