Zusammenfassung
Cell migration plays an essential role in many physiological processes such as embryogenesis, immune response, and wound healing. However, increased cell motility also contributes to invasion and metastases of tumor cells. Therefore, understanding the intracellular mechanisms which regulate cell migration is an important issue. In this paper a mathematical model describing the regulation of cofilin, which is a direct regulator of cell motility, is developed. The mathematical model is used to study the effects of different signaling stimuli on cofilin activity. In particular, the model analysis predicts that cell migration can be stopped reliably by a specific combined stimulation of the cofilin regulatory network. This hypothesis thus proposes a mechanism how cells may sustainably be kept at a fixed place without much signaling effort.
Nutzer
