L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR
Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.
%0 Journal Article
%1 blombach_l-valine_2009
%A Blombach, Bastian
%A Arndt, Annette
%A Auchter, Marc
%A Eikmanns, Bernhard J.
%D 2009
%J Appl. Environ. Microbiol.
%K Complex Corynebacterium Dehydrogenase Ethanol, Factors, Gene Knockout Pyruvate Techniques, Transcription Valine, glutamicum, myown
%N 4
%P 1197--1200
%R 10.1128/AEM.02351-08
%T L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR
%V 75
%X Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.
@article{blombach_l-valine_2009,
abstract = {Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.},
added-at = {2018-02-09T13:18:17.000+0100},
author = {Blombach, Bastian and Arndt, Annette and Auchter, Marc and Eikmanns, Bernhard J.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/205af8a7b28d60ba8272685f0427eaadb/bastian},
doi = {10.1128/AEM.02351-08},
interhash = {581b084966b1a19b10f06b5ed069aa58},
intrahash = {05af8a7b28d60ba8272685f0427eaadb},
issn = {1098-5336},
journal = {Appl. Environ. Microbiol.},
keywords = {Complex Corynebacterium Dehydrogenase Ethanol, Factors, Gene Knockout Pyruvate Techniques, Transcription Valine, glutamicum, myown},
language = {eng},
month = feb,
number = 4,
pages = {1197--1200},
pmcid = {PMC2643581},
pmid = {19088318},
timestamp = {2018-02-09T12:18:56.000+0100},
title = {L-valine production during growth of pyruvate dehydrogenase complex-deficient {Corynebacterium} glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator {SugR}},
volume = 75,
year = 2009
}
