Article

L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR

, , , and .
Appl. Environ. Microbiol. 75 (4): 1197--1200 (February 2009)
DOI: 10.1128/AEM.02351-08

Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

Tags

Users

  • @bastian

Comments and Reviews