Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA methyltransferase. No X-ray structure is available for the complex of Dnmt3a with DNA and the mechanistic details of DNA recognition and catalysis by mammalian Dnmts are not completely understood.
%0 Journal Article
%1 Lukashevich2016
%A Lukashevich, Olga V.
%A Cherepanova, Natalia A.
%A Jurkovska, Renata Z.
%A Jeltsch, Albert
%A Gromova, Elizaveta S.
%D 2016
%J BMC Biochemistry
%K ajeltsch ibtb-bc myown unibibliografie
%N 1
%P 7
%R 10.1186/s12858-016-0064-y
%T Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity
%U https://doi.org/10.1186/s12858-016-0064-y
%V 17
%X Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA methyltransferase. No X-ray structure is available for the complex of Dnmt3a with DNA and the mechanistic details of DNA recognition and catalysis by mammalian Dnmts are not completely understood.
@article{Lukashevich2016,
abstract = {Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA methyltransferase. No X-ray structure is available for the complex of Dnmt3a with DNA and the mechanistic details of DNA recognition and catalysis by mammalian Dnmts are not completely understood.},
added-at = {2022-12-05T10:53:42.000+0100},
author = {Lukashevich, Olga V. and Cherepanova, Natalia A. and Jurkovska, Renata Z. and Jeltsch, Albert and Gromova, Elizaveta S.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2207a5148b70893d457f7dddcfe2b6ab7/ajeltsch},
day = 22,
doi = {10.1186/s12858-016-0064-y},
interhash = {d3508eb3777bd0f43eb5dfc713cc75af},
intrahash = {207a5148b70893d457f7dddcfe2b6ab7},
issn = {1471-2091},
journal = {BMC Biochemistry},
keywords = {ajeltsch ibtb-bc myown unibibliografie},
month = mar,
number = 1,
pages = 7,
timestamp = {2023-11-14T19:21:36.000+0100},
title = {Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity},
url = {https://doi.org/10.1186/s12858-016-0064-y},
volume = 17,
year = 2016
}
