%0 Journal Article %1 ISI:000394434300004 %A Lange, Julian %A Takors, Ralf %A Blombach, Bastian %C 111 RIVER ST, HOBOKEN 07030-5774, NJ USA %D 2017 %I WILEY-BLACKWELL %J ENGINEERING IN LIFE SCIENCES %K myown %N 1 %P 27-35 %R 10.1002/elsc.201600108 %T Zero-growth bioprocesses: A challenge for microbial production strains and bioprocess engineering %U https://doi.org/10.1002/elsc.201600108 %V 17 %X Microbial fermentation of renewable feedstocks is an established technology in industrial biotechnology. Besides strict aerobic or anaerobic modes of operation, novel innovative and industrially applicable fermentation processes were developed connecting the advantages of aerobic and anaerobic conditions in a combined production approach. As a consequence, rapid aerobic biomass formation to high cell densities and subsequent anaerobic high-yield and zero-growth production is realized. Following this strategy, bioprocesses operating with substantial overall yield and productivity can be obtained. Here, we summarize the current knowledge and achievements in such microbial zero-growth production processes and pinpoint to challenges due to the complex adaptation of the cellular metabolism during the cell's passage from aerobiosis to anaerobiosis.

@article{ISI:000394434300004, abstract = {{Microbial fermentation of renewable feedstocks is an established technology in industrial biotechnology. Besides strict aerobic or anaerobic modes of operation, novel innovative and industrially applicable fermentation processes were developed connecting the advantages of aerobic and anaerobic conditions in a combined production approach. As a consequence, rapid aerobic biomass formation to high cell densities and subsequent anaerobic high-yield and zero-growth production is realized. Following this strategy, bioprocesses operating with substantial overall yield and productivity can be obtained. Here, we summarize the current knowledge and achievements in such microbial zero-growth production processes and pinpoint to challenges due to the complex adaptation of the cellular metabolism during the cell's passage from aerobiosis to anaerobiosis.}}, added-at = {2018-06-08T12:12:46.000+0200}, address = {{111 RIVER ST, HOBOKEN 07030-5774, NJ USA}}, affiliation = {{Blombach, B (Reprint Author), Univ Stuttgart, Inst Biochem Engn, Allmandring 31, D-70569 Stuttgart, Germany. Lange, Julian; Takors, Ralf; Blombach, Bastian, Univ Stuttgart, Inst Biochem Engn, Allmandring 31, D-70569 Stuttgart, Germany.}}, author = {Lange, Julian and Takors, Ralf and Blombach, Bastian}, author-email = {{blombach@ibvt.uni-stuttgart.de}}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2429dca6705ded0dc90e09931c9b764f9/ralftakors}, da = {{2018-01-26}}, doc-delivery-number = {{EL2FA}}, doi = {{10.1002/elsc.201600108}}, eissn = {{1618-2863}}, funding-acknowledgement = {{Ministry of Science, Research; Arts of Baden-Wurttemberg {[}33-7533-10-5/84]}}, funding-text = {{This work was supported by a grant from the Ministry of Science, Research and the Arts of Baden-Wurttemberg (Az: 33-7533-10-5/84) as part of the BBW ForWerts Graduate Program.}}, interhash = {6a3696379571b7458dbcd8797fde08f1}, intrahash = {429dca6705ded0dc90e09931c9b764f9}, issn = {{1618-0240}}, journal = {{ENGINEERING IN LIFE SCIENCES}}, journal-iso = {{Eng. Life Sci.}}, keywords = {myown}, keywords-plus = {{SUCCINIC ACID PRODUCTION; OXYGEN-DEPRIVATION CONDITIONS; EFFICIENT ISOBUTANOL PRODUCTION; ESCHERICHIA-COLI FERMENTATIONS; L-VALINE PRODUCTION; SCALE-DOWN SYSTEM; CORYNEBACTERIUM-GLUTAMICUM; ANAEROBIC CONDITIONS; SACCHAROMYCES-CEREVISIAE; MICROAEROBIC CONDITIONS}}, language = {{English}}, month = {{JAN}}, number = {{1}}, number-of-cited-references = {{105}}, oa = {{gold}}, pages = {{27-35}}, publisher = {{WILEY-BLACKWELL}}, research-areas = {{Biotechnology \& Applied Microbiology}}, times-cited = {{3}}, timestamp = {2018-06-08T10:12:46.000+0200}, title = {{Zero-growth bioprocesses: A challenge for microbial production strains and bioprocess engineering}}, type = {{Review}}, unique-id = {{ISI:000394434300004}}, url = {https://doi.org/10.1002/elsc.201600108}, usage-count-last-180-days = {{5}}, usage-count-since-2013 = {{9}}, volume = {{17}}, web-of-science-categories = {{Biotechnology \& Applied Microbiology}}, year = {{2017}} }