Abstract
A cascade of hydantoinase, N-carbamoylase and hydantoinracemase can be
used for the production of natural and unnatural chiral D- and L-amino
acids from chemically synthesized hydantoin derivatives. Potentially,
100\% conversion and 100\% optically pure amino acids can be obtained at
the same time if racemic substrates are used. Recent research activities
concentrate on newly isolated or improved enzymes and include directed
evolution techniques, structure elucidation, studies of fusion proteins
and the use of specially designed whole cell biocatalysts.
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