We report an electrochemical sensor for the detection of lithium ions (Li+) in authentic human saliva at lithium manganese oxide (LiMn2O4)-modified glassy carbon electrodes (LMO-GCEs) and screen-printed electrodes (LMO-SPEs). The sensing strategy is based on an initial galvanostatic delithiation of LMO followed by linear stripping voltammetry (LSV) to detect the reinsertion of Li+ in the analyte. The process was investigated using powder X-ray diffraction and voltammetry. LSV measurements reveal a measurable lower limit of 50.0 μM in both LiClO4 aqueous solutions and synthetic saliva samples, demonstrating the applicability of the proposed analytical method down to low Li+ concentrations. Four different samples of authentic human saliva were then analyzed with the established sensing strategy using LMO-SPEs, showing good linearity over a concentration range up to 5.0 mM Li+ with high reproducibility (RSD \textless 7\%) and applicability for routine monitoring purposes. The total time needed to analyze a sample is less than 3 min.
ACS Full Text Snapshot:files/4097/acssensors.html:text/html;Suherman et al_2019_Electrochemical Detection and Quantification of Lithium Ions in Authentic Human.pdf:files/4096/Suherman et al_2019_Electrochemical Detection and Quantification of Lithium Ions in Authentic Human.pdf:application/pdf
%0 Journal Article
%1 suherman_electrochemical_2019
%A Suherman, Alex L.
%A Rasche, Bertold
%A Godlewska, Beata
%A Nicholas, Philip
%A Herlihy, Shaun
%A Caiger, Nigel
%A Cowen, Philip J.
%A Compton, Richard G.
%D 2019
%J ACS Sens.
%K imported
%N 9
%P 2497--2506
%R 10.1021/acssensors.9b01176
%T Electrochemical Detection and Quantification of Lithium Ions in Authentic Human Saliva Using LiMn$_2$O$_4$-Modified Electrodes
%U https://doi.org/10.1021/acssensors.9b01176
%V 4
%X We report an electrochemical sensor for the detection of lithium ions (Li+) in authentic human saliva at lithium manganese oxide (LiMn2O4)-modified glassy carbon electrodes (LMO-GCEs) and screen-printed electrodes (LMO-SPEs). The sensing strategy is based on an initial galvanostatic delithiation of LMO followed by linear stripping voltammetry (LSV) to detect the reinsertion of Li+ in the analyte. The process was investigated using powder X-ray diffraction and voltammetry. LSV measurements reveal a measurable lower limit of 50.0 μM in both LiClO4 aqueous solutions and synthetic saliva samples, demonstrating the applicability of the proposed analytical method down to low Li+ concentrations. Four different samples of authentic human saliva were then analyzed with the established sensing strategy using LMO-SPEs, showing good linearity over a concentration range up to 5.0 mM Li+ with high reproducibility (RSD \textless 7\%) and applicability for routine monitoring purposes. The total time needed to analyze a sample is less than 3 min.
@article{suherman_electrochemical_2019,
abstract = {We report an electrochemical sensor for the detection of lithium ions (Li+) in authentic human saliva at lithium manganese oxide (LiMn2O4)-modified glassy carbon electrodes (LMO-GCEs) and screen-printed electrodes (LMO-SPEs). The sensing strategy is based on an initial galvanostatic delithiation of LMO followed by linear stripping voltammetry (LSV) to detect the reinsertion of Li+ in the analyte. The process was investigated using powder X-ray diffraction and voltammetry. LSV measurements reveal a measurable lower limit of 50.0 μM in both LiClO4 aqueous solutions and synthetic saliva samples, demonstrating the applicability of the proposed analytical method down to low Li+ concentrations. Four different samples of authentic human saliva were then analyzed with the established sensing strategy using LMO-SPEs, showing good linearity over a concentration range up to 5.0 mM Li+ with high reproducibility (RSD {\textless} 7\%) and applicability for routine monitoring purposes. The total time needed to analyze a sample is less than 3 min.},
added-at = {2024-03-25T12:35:57.000+0100},
author = {Suherman, Alex L. and Rasche, Bertold and Godlewska, Beata and Nicholas, Philip and Herlihy, Shaun and Caiger, Nigel and Cowen, Philip J. and Compton, Richard G.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2b11d2135908a5d60a8a29fb80396a8be/brasche},
doi = {10.1021/acssensors.9b01176},
file = {ACS Full Text Snapshot:files/4097/acssensors.html:text/html;Suherman et al_2019_Electrochemical Detection and Quantification of Lithium Ions in Authentic Human.pdf:files/4096/Suherman et al_2019_Electrochemical Detection and Quantification of Lithium Ions in Authentic Human.pdf:application/pdf},
interhash = {5ea3b4bebecd47c0c4e4dd912afc109a},
intrahash = {b11d2135908a5d60a8a29fb80396a8be},
journal = {ACS Sens.},
keywords = {imported},
month = sep,
number = 9,
pages = {2497--2506},
timestamp = {2024-03-25T12:35:57.000+0100},
title = {Electrochemical {Detection} and {Quantification} of {Lithium} {Ions} in {Authentic} {Human} {Saliva} {Using} {LiMn}$_{\textrm{2}}${O}$_{\textrm{4}}$-{Modified} {Electrodes}},
url = {https://doi.org/10.1021/acssensors.9b01176},
urldate = {2019-10-23},
volume = 4,
year = 2019
}