The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the Unfolded Protein Response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signaling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus we provide an integrated and global view of existing literature on ER signaling pathways and their use for therapeutic purposes. This article is protected by copyright. All rights reserved.
%0 Journal Article
%1 Almanza2018
%A Almanza, Aitor
%A Carlesso, Antonio
%A Chintha, Chetan
%A Creedican, Stuart
%A Doultsinos, Dimitrios
%A Leuzzi, Brian
%A Luís, Andreia
%A McCarthy, Nicole
%A Montibeller, Luigi
%A More, Sanket
%A Papaioannou, Alexandra
%A Püschel, Franziska
%A Sassano, Maria Livia
%A Skoko, Josip
%A Agostinis, Patrizia
%A de Belleroche, Jackie
%A Eriksson, Leif A.
%A Fulda, Simone
%A Gorman, Adrienne M
%A Healy, Sandra
%A Kozlov, Andrey
%A Muñoz-Pinedo, Cristina
%A Rehm, Markus
%A Chevet, Eric
%A Samali, Afshin
%D 2018
%J The FEBS Journal
%K 2018 izi morrison
%R 10.1111/febs.14608
%T Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
%U http://www.ncbi.nlm.nih.gov/pubmed/30027602
%X The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the Unfolded Protein Response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signaling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus we provide an integrated and global view of existing literature on ER signaling pathways and their use for therapeutic purposes. This article is protected by copyright. All rights reserved.
@article{Almanza2018,
abstract = {The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the Unfolded Protein Response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signaling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus we provide an integrated and global view of existing literature on ER signaling pathways and their use for therapeutic purposes. This article is protected by copyright. All rights reserved.},
added-at = {2023-06-29T13:07:55.000+0200},
author = {Almanza, Aitor and Carlesso, Antonio and Chintha, Chetan and Creedican, Stuart and Doultsinos, Dimitrios and Leuzzi, Brian and Lu{\'{i}}s, Andreia and McCarthy, Nicole and Montibeller, Luigi and More, Sanket and Papaioannou, Alexandra and P{\"{u}}schel, Franziska and Sassano, Maria Livia and Skoko, Josip and Agostinis, Patrizia and de Belleroche, Jackie and Eriksson, Leif A. and Fulda, Simone and Gorman, Adrienne M and Healy, Sandra and Kozlov, Andrey and Mu{\~{n}}oz-Pinedo, Cristina and Rehm, Markus and Chevet, Eric and Samali, Afshin},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2c434cfc068af16586bc6d865cfb79317/fabian},
doi = {10.1111/febs.14608},
interhash = {afd77f572e809376013c70e26cca9bd9},
intrahash = {c434cfc068af16586bc6d865cfb79317},
issn = {1742464X},
journal = {The FEBS Journal},
keywords = {2018 izi morrison},
month = jul,
pmid = {30027602},
timestamp = {2023-06-29T13:07:55.000+0200},
title = {{Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/30027602},
year = 2018
}