Publications

Sophia Steinlein, Frank Essmann, Amanda Franceschini Ghilardi, Heike Horn, Julia Schüler, Angelika Hausser, Lijun Sun, German Ott, and Claudia Kalla. Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in oncology, (13):1190988--1190988, Switzerland, May 2023. [PUMA: 2023 hausser izi] URL

Prateek Katiyar, Johannes Schwenck, Leonie Frauenfeld, Mathew R Divine, Vaibhav Agrawal, Ursula Kohlhofer, Sergios Gatidis, Roland Kontermann, Alfred Königsrainer, Leticia Quintanilla-Martinez, Christian la Fougère, Bernhard Schölkopf, Bernd J Pichler, and Jonathan A Disselhorst. Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data. Nature biomedical engineering, 10.1038/s41551-023-01047-9--, England, June 2023. [PUMA: 2023 izi kontermann] URL

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami I. Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K. M. Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Häcker, György Hajnóczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jäättelä, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri V. Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos López-Otín, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Muñoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Núñez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla V. Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, and Lorenzo Galluzzi. Apoptotic cell death in disease---Current understanding of the NCCD 2023. Cell Death & Differentiation, (30)5:1097--1154, May 1, 2023. [PUMA: 2023 izi morrison] URL

Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D Laman, and Ulrich L M Eisel. Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS. Journal of neuroinflammation, (20)1:106--106, England, May 2023. [PUMA: 2023 izi kontermann] URL

Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E Kontermann, Klaus Pfizenmaier, Ricarda Diem, and Sarah K Williams. Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis. Journal of neuroinflammation, (20)1:100--100, England, April 2023. [PUMA: 2023 izi kontermann] URL

Gavin Fullstone. Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs. Computational Modeling of Signaling Networks, 191--212, Springer US, 2023. [PUMA: 2023 izi morrison] URL

Cristiano Guttà, Christoph Morhard, and Markus Rehm. Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer. PLOS Computational Biology, (19)4:1-20, Public Library of Science, April 2023. [PUMA: 2023 EXC2075 izi morrison myown pn2 simtech] URL

Attila Ignácz, Domonkos Nagy-Herczeg, Angelika Hausser, and Katalin Schlett. Dendritic effects of genetically encoded actin labelling probes in cultured hippocampal neurons. In Stephanie L Gupton (Eds.), Molecular Biology of the Cell, American Society for Cell Biology (ASCB), March 2023. [PUMA: 2023 hausser izi] URL

Lennart Kühl, Annelie K. Schäfer, Sebastian Kraft, Nadine Aschmoneit, Roland E. Kontermann, and Oliver Seifert. eIg-based bispecific T-cell engagers targeting EGFR: Format matters. mAbs, (15)1:2183540, Taylor & Francis, 2023. [PUMA: 2023 izi kontermann] URL

Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A. Eisler, Tanja Hägele, Matthew A. H. Parson, John E. Burke, Angelika Hausser, and Thomas A. Leonard. PKD autoinhibition in trans regulates activation loop autophosphorylation in cis. Proceedings of the National Academy of Sciences, (120)7:e2212909120, 2023. [PUMA: 2023 hausser izi] URL

Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, and Tom Taghon. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nature Immunology, Jan 26, 2023. [PUMA: 2023 izi kontermann pfizenmaier] URL

Cristiano Guttà, Christoph Morhard, and Markus Rehm. T-GAN-D: a GAN-based classifier for breast cancer prognostication. Zenodo, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL

Cristiano Guttà, Christoph Morhard, and Markus Rehm. Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer. medRxiv, Cold Spring Harbor Laboratory Press, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL

Norbert Bencsik, Carlos Omar Oueslati Morales, Angelika Hausser, and Katalin Schlett. Endocytosis of AMPA receptors: Role in neurological conditions. Progress in Molecular Biology and Translational Science, Academic Press, 2022. [PUMA: 2022 hausser izi] URL

Dafne Müller. Targeting Co-Stimulatory Receptors of the TNF Superfamily for Cancer Immunotherapy. BioDrugs, (37)1:21--33, Jan 1, 2023. [PUMA: 2023 izi mueller] URL

Dafne Müller. Optimized CD19/CD22/CD3 antibody. Blood, (140)16:1750-1751, October 2022. [PUMA: 2022 izi mueller] URL

Cristiana Lungu, Florian Meyer, Marcel Hörning, Jasmin Steudle, Anja Braun, Bettina Noll, David Benz, Felix Fränkle, Simone Schmid, Stephan A Eisler, Monilola A Olayioye, and Correspondence A Monilola Olayioye. Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport. Traffic, John Wiley & Sons, Ltd, January 2023. [PUMA: 2023 izi olayioye] URL

Julio Vera, Xin Lai, Andreas Baur, Michael Erdmann, Shailendra Gupta, Cristiano Guttà, Lucie Heinzerling, Markus V Heppt, Philipp Maximilian Kazmierczak, Manfred Kunz, Christopher Lischer, Brigitte M Pützer, Markus Rehm, Christian Ostalecki, Jimmy Retzlaff, Stephan Witt, Olaf Wolkenhauer, and Carola Berking. Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence. Briefings in Bioinformatics, October 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Janine Dilchert, Martin Hofmann, Felix Unverdorben, Roland Kontermann, and Sebastian Bunk. Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules. Antibodies, (11)22022. [PUMA: 2022 izi kontermann] URL

Chiara Boccellato, and Markus Rehm. Glioblastoma, from disease understanding towards optimal cell-based in vitro models. Cellular Oncology, Jun 28, 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Oliver Seifert, and Roland E Kontermann. GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments. Molecules (Basel, Switzerland), (27)10:3272--, MDPI, May 2022. [PUMA: 2022 izi kontermann] URL

Agnieszka H. Ludwig-Słomczyńska, and Markus Rehm. Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases. Obesity, John Wiley & Sons, Ltd, May 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann, and Oliver Seifert. The eIg technology to generate Ig-like bispecific antibodies. mAbs, (14)1:2063043, Taylor & Francis, 2022. [PUMA: 2022 izi kontermann] URL

Yannick Frey, Mirita Franz-Wachtel, Boris Macek, and Monilola A. Olayioye. Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Scientific Reports 2022 12:1, (12)1:1--10, Nature Publishing Group, March 2022. [PUMA: 2022 izi olayioye] URL

Alexander Rau, Nicole Janssen, Lennart Kühl, Thomas Sell, Svetlana Kalmykova, Thomas E. Mürdter, Marc-H Dahlke, Christine Sers, Markus Morkel, Matthias Schwab, Roland E. Kontermann, and Monilola A. Olayioye. Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancerTriple HER blockade in CRC. Molecular Cancer Therapeutics, 2022. [PUMA: 2022 izi kontermann olayioye] URL

Rocío Mora-Molina, Daniela Stöhr, Markus Rehm, and Abelardo López-Rivas. cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. Cell Death & Disease, (13)2:111, Feb 3, 2022. [PUMA: 2022 izi morrison] URL

Nadine Aschmoneit, Katharina Kocher, Martin Siegemund, Martina S Lutz, Lennart Kühl, Oliver Seifert, and Roland E Kontermann. Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc). Oncoimmunology, (11)1:2028961--2028961, Taylor & Francis, January 2022. [PUMA: 2022 izi kontermann] URL

Cathrin Hagenlocher, Robin Siebert, Bruno Taschke, Senait Wieske, Angelika Hausser, and Markus Rehm. ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery, (8)1:34, Jan 24, 2022. [PUMA: 2022 EXC2075 hausser izi morrison pn2 simtech] URL

Greta Del Mistro, Shamala Riemann, Sebastian Schindler, Stefan Beissert, Roland E Kontermann, Aurelien Ginolhac, Rashi Halder, Luana Presta, Lasse Sinkkonen, Thomas Sauter, and Dagmar Kulms. Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma. Cell death & disease, (13)1:54--54, England, January 2022. [PUMA: 2022 izi kontermann] URL

Wolfgang Ehlers, Markus Morrison (Rehm), Patrick Schröder, Daniela Stöhr, and Arndt Wagner. Multiphasic modelling and computation of metastatic lung-cancer cell proliferation and atrophy in brain tissue based on experimental data. Biomechanics and Modeling in Mechanobiology, 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Nivetha Krishna Moorthy, Oliver Seifert, Stephan Eisler, Sara Weirich, Roland E. Kontermann, Markus Rehm, and Gavin Fullstone. Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma. Molecules 2021, Vol. 26, Page 7582, (26)24:7582, Multidisciplinary Digital Publishing Institute, December 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Nadine Pollak, Aline Lindner, Dirke Imig, Karsten Kuritz, Jacques S Fritze, Lorena Decker, Isabel Heinrich, Jannis Stadager, Stephan Eisler, Daniela Stöhr, Frank Allgöwer, Peter Scheurich, and Markus Rehm. Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis. Journal of cell science, jcs.258966--, England, November 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Nadine Aschmoneit, Lennart Kühl, Oliver Seifert, and Roland E Kontermann. Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release. Journal for immunotherapy of cancer, (9)11:e003616--, England, November 2021. [PUMA: 2021 izi kontermann] URL

Martin Siegemund, Prajakta Oak, Eva-Maria Hansbauer, Andrea Allersdorfer, Karoline Utschick, Alexandra Winter, Christina Grasmüller, Gunther Galler, Jan-Peter Mayer, Benjamin Weiche, Josef Prassler, Roland E Kontermann, and Christine Rothe. Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Frontiers in pharmacology, (12):759337--759337, Frontiers Media S.A., October 2021. [PUMA: 2021 izi kontermann] URL

Roland E Kontermann, Guy Ungerechts, and Dirk M Nettelbeck. Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics. mAbs, (13)1:1982447--1982447, Taylor & Francis, 2021. [PUMA: 2021 izi kontermann] URL

Irini Papazian, Eleni Tsoukala, Athena Boutou, Maria Karamita, Konstantinos Kambas, Lida Iliopoulou, Roman Fischer, Roland E Kontermann, Maria C Denis, George Kollias, Hans Lassmann, and Lesley Probert. Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. Journal of neuroinflammation, (18)1:222--222, BioMed Central, September 2021. [PUMA: 2021 izi kontermann] URL

Andreas Ulrich Lindner, Manuela Salvucci, Elizabeth McDonough, Sanghee Cho, Xanthi Stachtea, Emer P. O'Connell, Alex D. Corwin, Alberto Santamaria-Pang, Steven Carberry, Michael Fichtner, Sandra Van Schaeybroeck, Pierre Laurent-Puig, John P. Burke, Deborah A. McNamara, Mark Lawler, Anup Sood, John F. Graf, Markus Rehm, Philip D. Dunne, Daniel B. Longley, Fiona Ginty, and Jochen H. M. Prehn. An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell Death & Differentiation, Nov 9, 2021. [PUMA: 2021 izi morrison] URL

Carlos O. Oueslati Morales, Attila Ignácz, Norbert Bencsik, Zsofia Sziber, Anikó Erika Rátkai, Wolfgang S. Lieb, Stephan A. Eisler, Attila Szűcs, Katalin Schlett, and Angelika Hausser. Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic, (n/a)n/a2021. [PUMA: 2021 hausser izi] URL

Christian T. Hellwig, M. Eugenia Delgado, Josip Skoko, Lydia Dyck, Carol Hanna, Alexa Wentges, Claudia Langlais, Cathrin Hagenlocher, Alexandra Mack, David Dinsdale, Kelvin Cain, Marion MacFarlane, and Markus Rehm. Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death & Differentiation 2021, 1--9, Nature Publishing Group, August 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Viktorija Juric, Lance Hudson, Joanna Fay, Cathy E. Richards, Hanne Jahns, Maïté Verreault, Franck Bielle, Ahmed Idbaih, Martine L. M. Lamfers, Ann M. Hopkins, Markus Rehm, and Brona M. Murphy. Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Cell Death & Disease 2021 12:8, (12)8:1--12, Nature Publishing Group, August 2021. [PUMA: 2021 izi morrison] URL

N Aschmoneit, S Steinlein, L Kühl, O Seifert, and Roland E. Kontermann. A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells. Scientific reports, (11)1:13880, Sci Rep, December 2021. [PUMA: 2021 izi kontermann] URL

Vittoria Massafra, Sofia Tundo, Aline Dietzig, Axel Ducret, Christian Jost, Christian Klein, Roland E. Kontermann, Hendrik Knoetgen, Martin Steegmaier, Andrea Romagnani, and Yvonne A. Nagel. Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells. The Journal of Immunology, American Association of Immunologists, 2021. [PUMA: 2021 izi kontermann] URL

Fabian Richter, Sarah K. Williams, Katharina John, Carina Huber, Camille Vaslin, Henri Zanker, Richard Fairless, Kira Pichi, Silke Marhenke, Arndt Vogel, Marie-Ann Dhaen, Stefanie Herrmann, Andreas Herrmann, Klaus Pfizenmaier, Heike Bantel, Ricarda Diem, Roland E. Kontermann, and Roman Fischer. The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. Frontiers in Immunology, (12)Frontiers Media SA, July 2021. [PUMA: 2021 fischer izi kontermann] URL

Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy, and Markus Rehm. Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell Death & Disease, (12)7:647, Nature Publishing Group, July 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Ulrich Brinkmann, and Roland E. Kontermann. Bispecific antibodies. Science, (372)6545:916--917, American Association for the Advancement of Science, 2021. [PUMA: 2021 izi kontermann] URL

Viktorija Juric, Heiko Düssmann, Martine L M Lamfers, Jochen H M Prehn, Markus Rehm, and Brona M Murphy. Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells 2021, Vol. 10, Page 1182, (10)5:1182, Multidisciplinary Digital Publishing Institute, May 2021. [PUMA: 2021 izi morrison] URL

Christopher McCann, Anna Matveeva, Katherine McAllister, Tamas Sessler, Michael Fichtner, Steven Carberry, Markus Rehm, Jochen H.M. Prehn, and Daniel B. Longley. Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. The FEBS Journal, febs.15801, John Wiley & Sons, Ltd, March 2021. [PUMA: 2021 izi morrison] URL

John R Bethea, and Roman Fischer. Role of peripheral immune cells for development and recovery of chronic pain. Frontiers in Immunology, (12)Frontiers, 2021. [PUMA: 2021 fischer izi] URL

Hajrah Khawaja, Andrew Campbell, Jamie Z. Roberts, Arman Javadi, Paul O’Reilly, Darragh McArt, Wendy L. Allen, Joanna Majkut, Markus Rehm, Alberto Bardelli, Federica Di Nicolantonio, Christopher J. Scott, Richard Kennedy, Nicolas Vitale, Timothy Harrison, Owen J. Sansom, Daniel B. Longley, Emma Evergren, and Sandra Van Schaeybroeck. RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. Cell Death & Disease, (11)10:930--, 2020. [PUMA: 2020 izi morrison] URL

K. White, K. Connor, J. Clerkin, B.M. Murphy, M. Salvucci, A.C. O'Farrell, M. Rehm, D. O'Brien, J.H.M. Prehn, S.P. Niclou, M.L.M. Lamfers, M. Verreault, A. Idbaih, R. Verhaak, A. Golebiewska, and A.T. Byrne. New hints towards a precision medicine strategy for IDH wild-type Glioblastoma. Annals of Oncology, Ann Oncol, September 2020. [PUMA: 2020 izi morrison] URL

Daniela Stöhr, and Markus Rehm. Linking hyperosmotic stress and apoptotic sensitivity. The FEBS Journal, febs.15520, Blackwell Publishing Ltd, August 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

F Hartung, T Krüwel, X Shi, K Pfizenmaier, R Kontermann, P Chames, F Alves, and L A Pardo. A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells. Front Pharmacol, (11):686-686, 2020. [PUMA: 2020 izi kontermann] URL

S Sapski, N Beha, R E Kontermann, and D Müller. Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response. Cancer Immunol Immunother, June 2020. [PUMA: 2020 izi kontermann] URL

Dirke Imig, Nadine Pollak, Frank Allgöwer, and Markus Rehm. Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis. PLOS Computational Biology, (16)6:1-17, Public Library of Science, June 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Natalia Pacheco-Fernandez, Mehrshad Pakdel, Birgit Blank, Ismael Sanchez-Gonzalez, Kathrin Weber, Mai Ly Tran, Tobias Karl-Heinz Hecht, Renate Gautsch, Gisela Beck, Franck Perez, Angelika Hausser, Stefan Linder, and Julia von Blume. Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. Journal of Cell Biology, (219)8Rockefeller University Press, June 2020. [PUMA: 2020 hausser izi] URL

A Rau, W S Lieb, O Seifert, J Honer, D Birnstock, F Richter, N Aschmoneit, M A Olayioye, and R E Kontermann. Inhibition of tumor cell growth and cancer stem cell expansion by a bispecific antibody targeting EGFR and HER3. Mol Cancer Ther, May 2020. [PUMA: 2020 izi kontermann olayioye] URL

Daniela Stöhr, Jens O. Schmid, Tobias B. Beigl, Alexandra Mack, Daniela S. Maichl, Kai Cao, Beate Budai, Gavin Fullstone, Roland E. Kontermann, Thomas E. Mürdter, Stephen W. G. Tait, Cathrin Hagenlocher, Nadine Pollak, Peter Scheurich, and Markus Rehm. Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Roman Fischer, Roland E. Kontermann, and Klaus Pfizenmaier. Selective targeting of TNF receptors as a novel therapeutic approach. Frontiers in Cell and Developmental Biology, (8)Frontiers, 2020. [PUMA: 2020 fischer izi kontermann pfizenmaier] URL

Valentina Pegoretti, Kathryn A. Swanson, John R. Bethea, Lesley Probert, Ulrich L. M. Eisel, and Roman Fischer. Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity, (2020):19, 2020. [PUMA: 2020 fischer izi] URL

Felista L. Tansi, Ronny Rüger, Ansgar M. Kollmeier, Markus Rabenhold, Frank Steiniger, Roland E. Kontermann, Ulf K. Teichgräber, Alfred Fahr, and Ingrid Hilger. Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes. Pharmaceutics, (12)4:370, MDPI AG, April 2020. [PUMA: 2020 izi kontermann] URL

Gavin Fullstone, Tabea L. Bauer, Cristiano Guttà, Manuela Salvucci, Jochen H. M. Prehn, and Markus Rehm. The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL

F Wandrer, S Liebig, S Marhenke, A Vogel, K John, M P Manns, A Teufel, T Itzel, T Longerich, O Maier, R Fischer, R E Kontermann, K Pfizenmaier, K Schulze-Osthoff, and H Bantel. TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice. Cell Death Dis, (11)3:212-212, March 2020. [PUMA: 2020 izi kontermann] URL

Gavin Fullstone, Cristiano Guttà, Amatus Beyer, and Markus Rehm. The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling. npj Systems Biology and Applications, (6)1:10--, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

D Stöhr, A Jeltsch, and M Rehm. TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response. Int Rev Cell Mol Biol, (351):57-99, 2020. [PUMA: 2020 izi morrison] URL

Myriam Fabre, Cristina Ferrer, Saioa Dominguez-Hormaetxe, Bruno Bockorny, Laura Murias, Oliver Seifert, Stephan A. Eisler, Roland E. Kontermann, Klaus Pfizenmaier, So Young Lee, Maria dM Vivanco, Pedro P Lopez-Casas, Sofia Perea, Muhammad Abbas, Wolfgang Richter, Laureano Simón, and Manuel Hidalgo. OMTX705, a Novel FAP-Targeting ADC demonstrates Activity in Chemotherapy and PD1-Resistant Solid Tumors Models. Clinical Cancer Research, clincanres.2238.2019, Clin Cancer Res, March 2020. [PUMA: 2020 izi kontermann pfizenmaier] URL

Karsten Kuritz, Daniela Stöhr, Daniela Simone Maichl, Nadine Pollak, Markus Rehm, and Frank Allgöwer. Reconstructing temporal and spatial dynamics from single-cell pseudotime using prior knowledge of real scale cell densities. Scientific Reports, (10)1:3619, Nature Publishing Group, December 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Vesna Vetma, Cristiano Guttà, Nathalie Peters, Christian Praetorius, Meike Hutt, Oliver Seifert, Friedegund Meier, Roland Kontermann, Dagmar Kulms, and Markus Rehm. Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism. Cell Death & Differentiation 2020, 1--16, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL

Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher, and Markus Rehm. Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell Death & Disease, (11)2:124, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL

Shuya Zhang, Huan Liu, Meimei Yin, Xiuying Pei, Angelika Hausser, Eri Ishikawa, Sho Yamasaki, and Zheng Gen Jin. Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice. Hepatology, hep.31176, John Wiley & Sons, Ltd, February 2020. [PUMA: 2020 hausser izi] URL

Ines Müller, Elwira Strozyk, Sebastian Schindler, Stefan Beissert, Htoo Zarni Oo, Thomas Sauter, Philippe Lucarelli, Sebastian Raeth, Angelika Hausser, Nader Al Nakouzi, Ladan Fazli, Martin E. Gleave, He Liu, Hans-Uwe Simon, Henning Walczak, Douglas R. Green, Jiri Bartek, Mads Daugaard, and Dagmar Kulms. Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Molecular Cell, January 2020. [PUMA: 2020 hausser izi] URL

Ismael Sánchez-González, Anja Bobien, Christian Molnar, Simone Schmid, Michaela Strotbek, Melanie Boerries, Hauke Busch, and Monilola A Olayioye. miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages. Cancer Research, canres.1934.2019, January 2020. [PUMA: 2020 izi olayioye] URL

Monilola A. Olayioye, Bettina Noll, and Angelika Hausser. Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases. Cells, (8)12:1478, Multidisciplinary Digital Publishing Institute, November 2019. [PUMA: 2019 hausser izi olayioye] URL

Anja Schrade, Alexander Bujotzek, Christian Spick, Martina Wagner, Johannes Goerl, Xenia Wezler, Guy Georges, Roland E Kontermann, and Ulrich Brinkmann. Back-To-Germline (B2G) Procedure for Antibody Devolution. Antibodies, (8)3:45, August 2019. [PUMA: 2019 izi kontermann] URL

Wolfgang Sebastian Lieb, Cristiana Lungu, Raluca Tamas, Hannah Berreth, Philipp Rathert, Peter Storz, Monilola A. Olayioye, and Angelika Hausser. The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells. International Journal of Cancer, ijc.32798, John Wiley & Sons, Ltd, November 2019. [PUMA: 2019 hausser izi olayioye] URL

Tanja Padutsch, Sendetski Maksim, Carina Huber, Nathalie Peters, Klaus Pfizenmaier, John R Bethea, Roland E. Kontermann, and Roman Fischer. Superior Treg-expanding properties of a novel dual-acting cytokine fusion protein. Frontiers in Pharmacology, (10):1490, Frontiers, 2019. [PUMA: 2019 fischer izi kontermann] URL

Markus Kleih, Kathrin Böpple, Meng Dong, Andrea Gaißler, Simon Heine, Monilola A. Olayioye, Walter E. Aulitzky, and Frank Essmann. Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death & Disease, (10)11:851, Nature Publishing Group, November 2019. [PUMA: 2019 izi olayioye] URL

N. Tsur, Y. Kogan, M. Rehm, and Z. Agur. Response of Patients with Melanoma to Immune Checkpoint Blockade – Insights Gleaned from Analysis of a New Mathematical Mechanistic Model. Journal of Theoretical Biology, 110033, Academic Press, September 2019. [PUMA: 2019 izi morrison] URL

Roman Fischer, Maksim Sendetski, Tania Del Rivero, George F Martinez, Valerie Bracchi-Ricard, Kathryn A Swanson, Elizabeth K Pruzinsky, Niky Delguercio, Michael J Rosalino, Tanja Padutsch, Roland E Kontermann, Klaus Pfizenmaier, and John R Bethea. TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.. Proceedings of the National Academy of Sciences of the United States of America, (116)34:17045--17050, National Academy of Sciences, August 2019. [PUMA: 2019 izi kontermann] URL

Julia von Blume, and Angelika Hausser. Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network. FEBS Letters, 1873--3468.13552, John Wiley & Sons, Ltd, July 2019. [PUMA: 2019 hausser izi] URL

Roman Fischer, Tanja Padutsch, Valerie Bracchi-Ricard, Kayla L. Murphy, George.F. Martinez, Niky Delguercio, Nicholas Elmer, Maksim Sendetski, Ricarda Diem, Ulrich L.M. Eisel, Richard J. Smeyne, Roland E. Kontermann, Klaus Pfizenmaier, and John R. Bethea. Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain, Behavior, and Immunity, June 2019. [PUMA: 2019 izi kontermann pfizenmaier] URL

Bettina Noll, David Benz, Yannick Frey, Florian Meyer, Manuel Lauinger, Stephan A Eisler, Simone Schmid, Peter L Hordijk, and Monilola A Olayioye. DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.. Journal of cell science, jcs.223172, The Company of Biologists Ltd, May 2019. [PUMA: 2019 izi olayioye] URL

Nadine Beha, Markus Harder, Sarah Ring, Roland E. Kontermann, and Dafne Müller. IL-15-based trifunctional antibody-fusion proteins with costimulatory TNF-superfamily ligands in the single-chain format for cancer immunotherapy. Molecular Cancer Therapeutics, molcanther.1204.2018, April 2019. [PUMA: 2019 izi kontermann mueller] URL

Manuela Salvucci, Arman Rahman, Alexa J Resler, Girish M Udupi, Deborah A McNamara, Elaine W Kay, Pierre Laurent-Puig, Daniel B Longley, Patrick G Johnston, Mark Lawler, Richard Wilson, Manuel Salto-Tellez, Sandra Van Schaeybroeck, Mairin Rafferty, William M Gallagher, Markus Rehm, and Jochen H M Prehn. A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.. JCO clinical cancer informatics, 3:1--17, American Society of Clinical Oncology, April 2019. [PUMA: 2019 izi morrison] URL

Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter, and Roland E. Kontermann. Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs, 19420862.2019.1603024, April 2019. [PUMA: 2019 izi kontermann] URL

Fabian Richter, Oliver Seifert, Andreas Herrmann, Klaus Pfizenmaier, and Roland E. Kontermann. Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc. mAbs, 1--13, Taylor & Francis, March 2019. [PUMA: 2019 izi kontermann pfizenmaier] URL

Biswajit Podder, Cristiano Guttà, Jan Rožanc, Elke Gerlach, Maria Feoktistova, Diana Panayotova-Dimitrova, Leonidas G. Alexopoulos, Martin Leverkus, and Markus Rehm. TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Cell Death & Differentiation, 1, Nature Publishing Group, March 2019. [PUMA: 2019 izi morrison myown] URL

Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, and Markus Rehm. Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. BMC Cell Biology, (19)1:28, December 2019. [PUMA: 2019 izi morrison] URL

Greta Del Mistro, Philippe Lucarelli, Ines Müller, Sébastien De Landtsheer, Anna Zinoveva, Meike Hutt, Martin Siegemund, Roland E. Kontermann, Stefan Beissert, Thomas Sauter, and Dagmar Kulms. Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. npj Systems Biology and Applications, (4)1:39, December 2018. [PUMA: 2018 izi kontermann] URL

Pilar Puerto-Camacho, Ana Teresa Amaral, Salah-Eddine Lamhamedi-Cherradi, Brian A Menegaz, Helena Castillo-Ecija, José Luis Ordóñez, Saioa Dominguez-Hormaetxe, Carmen Jordan-Perez, Juan Diaz-Martin, Laura Romero-Pérez, Maria Lopez-Alvarez, Gema Civantos-Jubera, María José Robles-Frias, Michele Biscuola, Cristina Ferrer, Jaume Mora, Branko Cuglievan, Keri L. Schadler, Oliver Seifert, Roland E. Kontermann, Klaus Pfizenmaier, Laureano Simon, Myriam Fabre, Angel M. Carcaboso, Joseph A Ludwig, and Enrique de Álava. Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma. Clinical Cancer Research, clincanres.0936.2018, November 2018. [PUMA: 2018 izi kontermann] URL

Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, and Markus Rehm. Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease, (9)11:1112, November 2018. [PUMA: 2018 izi kontermann morrison] URL

Jan Rožanc, Theodore Sakellaropoulos, Asier Antoranz, Cristiano Guttà, Biswajit Podder, Vesna Vetma, Nicole Rufo, Patrizia Agostinis, Vaia Pliaka, Thomas Sauter, Dagmar Kulms, Markus Rehm, and Leonidas Alexopoulos. Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death & Differentiation, 1, October 2018. [PUMA: 2018 izi morrison myown] URL

Fabian Richter, Kirstin A. Zettlitz, Oliver Seifert, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier, and Roland E. Kontermann. Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity. mAbs, 19420862.2018.1524664, September 2018. [PUMA: 2018 izi kontermann] URL

Alessandro Satta, Delia Mezzanzanica, Francesco Caroli, Barbara Frigerio, Massimo Di Nicola, Roland E. Kontermann, Federico Iacovelli, Alessandro Desideri, Andrea Anichini, Silvana Canevari, Alessandro Massimo Gianni, and Mariangela Figini. Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells. mAbs, 19420862.2018.1494105, July 2018. [PUMA: 2018 izi kontermann] URL

Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier, and Ricarda Diem. Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports, (8)1:13628, December 2018. [PUMA: 2018 izi kontermann] URL

Sina Fellermeier-Kopf, Friederike Gieseke, Ugur Sahin, Dafne Müller, Klaus Pfizenmaier, and Roland E. Kontermann. Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans. OncoImmunology, (7)9:e1471442, Taylor & Francis, September 2018. [PUMA: 2018 izi kontermann] URL

Antje Jensch, Yannick Frey, Katharina Bitschar, Patrick Weber, Simone Schmid, Angelika Hausser, Monilola A. Olayioye, and Nicole E. Radde. The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function. Journal of Biological Chemistry, jbc.RA118.003787, July 2018. [PUMA: 2018 hausser izi olayioye] URL

Stephan A Eisler, Filipa Curado, Gisela Link, Sarah Schulz, Melanie Noack, Maren Steinke, Monilola A Olayioye, and Angelika Hausser. A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions. eLife, (7)July 2018. [PUMA: 2018 hausser izi olayioye] URL

Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Rehm, Eric Chevet, and Afshin Samali. Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications. The FEBS Journal, July 2018. [PUMA: 2018 izi morrison] URL

Lubna Danish, Dirke Imig, Frank Allgöwer, Peter Scheurich, and Nadine Pollak. Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLOS ONE, (13)6:1-19, Public Library of Science, June 2018. [PUMA: 2018 izi pollak scheuric] URL

Mingjia Chen, Mounashree J Urs, Ismael Sánchez-González, Monilola A Olayioye, Marco Herde, and Claus-Peter Witte. m6A RNA Degradation Products are Catabolized by an Evolutionarily Conserved N6-methyl-AMP Deaminase in Plant and Mammalian Cells.. The Plant cell, tpc.00236.2018, American Society of Plant Biologists, June 2018. [PUMA: 2018 izi olayioye] URL