Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Frontiers in oncology, (13):1190988--1190988, Switzerland, May 2023. [PUMA: 2023 hausser izi] URL
Quantification of intratumoural heterogeneity in mice and patients via machine-learning models trained on PET-MRI data. Nature biomedical engineering, 10.1038/s41551-023-01047-9--, England, June 2023. [PUMA: 2023 izi kontermann] URL
Apoptotic cell death in disease---Current understanding of the NCCD 2023. Cell Death & Differentiation, (30)5:1097--1154, May 1, 2023. [PUMA: 2023 izi morrison] URL
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS. Journal of neuroinflammation, (20)1:106--106, England, May 2023. [PUMA: 2023 izi kontermann] URL
Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis. Journal of neuroinflammation, (20)1:100--100, England, April 2023. [PUMA: 2023 izi kontermann] URL
Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs. Computational Modeling of Signaling Networks, 191--212, Springer US, 2023. [PUMA: 2023 izi morrison] URL
Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer. PLOS Computational Biology, (19)4:1-20, Public Library of Science, April 2023. [PUMA: 2023 EXC2075 izi morrison myown pn2 simtech] URL
Dendritic effects of genetically encoded actin labelling probes in cultured hippocampal neurons. In Stephanie L Gupton (Eds.), Molecular Biology of the Cell, American Society for Cell Biology (ASCB), March 2023. [PUMA: 2023 hausser izi] URL
eIg-based bispecific T-cell engagers targeting EGFR: Format matters. mAbs, (15)1:2183540, Taylor & Francis, 2023. [PUMA: 2023 izi kontermann] URL
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis. Proceedings of the National Academy of Sciences, (120)7:e2212909120, 2023. [PUMA: 2023 hausser izi] URL
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nature Immunology, Jan 26, 2023. [PUMA: 2023 izi kontermann pfizenmaier] URL
T-GAN-D: a GAN-based classifier for breast cancer prognostication. Zenodo, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL
Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer. medRxiv, Cold Spring Harbor Laboratory Press, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL
Endocytosis of AMPA receptors: Role in neurological conditions. Progress in Molecular Biology and Translational Science, Academic Press, 2022. [PUMA: 2022 hausser izi] URL
Targeting Co-Stimulatory Receptors of the TNF Superfamily for Cancer Immunotherapy. BioDrugs, (37)1:21--33, Jan 1, 2023. [PUMA: 2023 izi mueller] URL
Optimized CD19/CD22/CD3 antibody. Blood, (140)16:1750-1751, October 2022. [PUMA: 2022 izi mueller] URL
Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport. Traffic, John Wiley & Sons, Ltd, January 2023. [PUMA: 2023 izi olayioye] URL
Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence. Briefings in Bioinformatics, October 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL
Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules. Antibodies, (11)22022. [PUMA: 2022 izi kontermann] URL
Glioblastoma, from disease understanding towards optimal cell-based in vitro models. Cellular Oncology, Jun 28, 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL
GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments. Molecules (Basel, Switzerland), (27)10:3272--, MDPI, May 2022. [PUMA: 2022 izi kontermann] URL
Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases. Obesity, John Wiley & Sons, Ltd, May 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL
The eIg technology to generate Ig-like bispecific antibodies. mAbs, (14)1:2063043, Taylor & Francis, 2022. [PUMA: 2022 izi kontermann] URL
Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7. Scientific Reports 2022 12:1, (12)1:1--10, Nature Publishing Group, March 2022. [PUMA: 2022 izi olayioye] URL
Triple targeting of HER receptors overcomes heregulin-mediated resistance to EGFR blockade in colorectal cancerTriple HER blockade in CRC. Molecular Cancer Therapeutics, 2022. [PUMA: 2022 izi kontermann olayioye] URL
cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. Cell Death & Disease, (13)2:111, Feb 3, 2022. [PUMA: 2022 izi morrison] URL
Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc). Oncoimmunology, (11)1:2028961--2028961, Taylor & Francis, January 2022. [PUMA: 2022 izi kontermann] URL
ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery, (8)1:34, Jan 24, 2022. [PUMA: 2022 EXC2075 hausser izi morrison pn2 simtech] URL
Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma. Cell death & disease, (13)1:54--54, England, January 2022. [PUMA: 2022 izi kontermann] URL
Multiphasic modelling and computation of metastatic lung-cancer cell proliferation and atrophy in brain tissue based on experimental data. Biomechanics and Modeling in Mechanobiology, 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL
Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma. Molecules 2021, Vol. 26, Page 7582, (26)24:7582, Multidisciplinary Digital Publishing Institute, December 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis. Journal of cell science, jcs.258966--, England, November 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL
Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release. Journal for immunotherapy of cancer, (9)11:e003616--, England, November 2021. [PUMA: 2021 izi kontermann] URL
Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Frontiers in pharmacology, (12):759337--759337, Frontiers Media S.A., October 2021. [PUMA: 2021 izi kontermann] URL
Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics. mAbs, (13)1:1982447--1982447, Taylor & Francis, 2021. [PUMA: 2021 izi kontermann] URL
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice. Journal of neuroinflammation, (18)1:222--222, BioMed Central, September 2021. [PUMA: 2021 izi kontermann] URL
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell Death & Differentiation, Nov 9, 2021. [PUMA: 2021 izi morrison] URL
Protein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic, (n/a)n/a2021. [PUMA: 2021 hausser izi] URL
Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death & Differentiation 2021, 1--9, Nature Publishing Group, August 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL
Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Cell Death & Disease 2021 12:8, (12)8:1--12, Nature Publishing Group, August 2021. [PUMA: 2021 izi morrison] URL
A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells. Scientific reports, (11)1:13880, Sci Rep, December 2021. [PUMA: 2021 izi kontermann] URL
Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells. The Journal of Immunology, American Association of Immunologists, 2021. [PUMA: 2021 izi kontermann] URL
The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation. Frontiers in Immunology, (12)Frontiers Media SA, July 2021. [PUMA: 2021 fischer izi kontermann] URL
Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell Death & Disease, (12)7:647, Nature Publishing Group, July 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL
Bispecific antibodies. Science, (372)6545:916--917, American Association for the Advancement of Science, 2021. [PUMA: 2021 izi kontermann] URL
Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells 2021, Vol. 10, Page 1182, (10)5:1182, Multidisciplinary Digital Publishing Institute, May 2021. [PUMA: 2021 izi morrison] URL
Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. The FEBS Journal, febs.15801, John Wiley & Sons, Ltd, March 2021. [PUMA: 2021 izi morrison] URL
Role of peripheral immune cells for development and recovery of chronic pain. Frontiers in Immunology, (12)Frontiers, 2021. [PUMA: 2021 fischer izi] URL
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer. Cell Death & Disease, (11)10:930--, 2020. [PUMA: 2020 izi morrison] URL
New hints towards a precision medicine strategy for IDH wild-type Glioblastoma. Annals of Oncology, Ann Oncol, September 2020. [PUMA: 2020 izi morrison] URL
Linking hyperosmotic stress and apoptotic sensitivity. The FEBS Journal, febs.15520, Blackwell Publishing Ltd, August 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL
A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells. Front Pharmacol, (11):686-686, 2020. [PUMA: 2020 izi kontermann] URL
Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response. Cancer Immunol Immunother, June 2020. [PUMA: 2020 izi kontermann] URL
Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis. PLOS Computational Biology, (16)6:1-17, Public Library of Science, June 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL
Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. Journal of Cell Biology, (219)8Rockefeller University Press, June 2020. [PUMA: 2020 hausser izi] URL
Inhibition of tumor cell growth and cancer stem cell expansion by a bispecific antibody targeting EGFR and HER3. Mol Cancer Ther, May 2020. [PUMA: 2020 izi kontermann olayioye] URL
Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL
Selective targeting of TNF receptors as a novel therapeutic approach. Frontiers in Cell and Developmental Biology, (8)Frontiers, 2020. [PUMA: 2020 fischer izi kontermann pfizenmaier] URL
Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity, (2020):19, 2020. [PUMA: 2020 fischer izi] URL
Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes. Pharmaceutics, (12)4:370, MDPI AG, April 2020. [PUMA: 2020 izi kontermann] URL
The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice. Cell Death Dis, (11)3:212-212, March 2020. [PUMA: 2020 izi kontermann] URL
The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling. npj Systems Biology and Applications, (6)1:10--, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL
TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response. Int Rev Cell Mol Biol, (351):57-99, 2020. [PUMA: 2020 izi morrison] URL
OMTX705, a Novel FAP-Targeting ADC demonstrates Activity in Chemotherapy and PD1-Resistant Solid Tumors Models. Clinical Cancer Research, clincanres.2238.2019, Clin Cancer Res, March 2020. [PUMA: 2020 izi kontermann pfizenmaier] URL
Reconstructing temporal and spatial dynamics from single-cell pseudotime using prior knowledge of real scale cell densities. Scientific Reports, (10)1:3619, Nature Publishing Group, December 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL
Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism. Cell Death & Differentiation 2020, 1--16, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL
Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell Death & Disease, (11)2:124, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL
Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice. Hepatology, hep.31176, John Wiley & Sons, Ltd, February 2020. [PUMA: 2020 hausser izi] URL
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28. Molecular Cell, January 2020. [PUMA: 2020 hausser izi] URL
miR-149 suppresses breast cancer metastasis by blocking paracrine interactions with macrophages. Cancer Research, canres.1934.2019, January 2020. [PUMA: 2020 izi olayioye] URL
Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases. Cells, (8)12:1478, Multidisciplinary Digital Publishing Institute, November 2019. [PUMA: 2019 hausser izi olayioye] URL
Back-To-Germline (B2G) Procedure for Antibody Devolution. Antibodies, (8)3:45, August 2019. [PUMA: 2019 izi kontermann] URL
The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells. International Journal of Cancer, ijc.32798, John Wiley & Sons, Ltd, November 2019. [PUMA: 2019 hausser izi olayioye] URL
Superior Treg-expanding properties of a novel dual-acting cytokine fusion protein. Frontiers in Pharmacology, (10):1490, Frontiers, 2019. [PUMA: 2019 fischer izi kontermann] URL
Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Cell Death & Disease, (10)11:851, Nature Publishing Group, November 2019. [PUMA: 2019 izi olayioye] URL
Response of Patients with Melanoma to Immune Checkpoint Blockade – Insights Gleaned from Analysis of a New Mathematical Mechanistic Model. Journal of Theoretical Biology, 110033, Academic Press, September 2019. [PUMA: 2019 izi morrison] URL
TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.. Proceedings of the National Academy of Sciences of the United States of America, (116)34:17045--17050, National Academy of Sciences, August 2019. [PUMA: 2019 izi kontermann] URL
Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network. FEBS Letters, 1873--3468.13552, John Wiley & Sons, Ltd, July 2019. [PUMA: 2019 hausser izi] URL
Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis. Brain, Behavior, and Immunity, June 2019. [PUMA: 2019 izi kontermann pfizenmaier] URL
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.. Journal of cell science, jcs.223172, The Company of Biologists Ltd, May 2019. [PUMA: 2019 izi olayioye] URL
IL-15-based trifunctional antibody-fusion proteins with costimulatory TNF-superfamily ligands in the single-chain format for cancer immunotherapy. Molecular Cancer Therapeutics, molcanther.1204.2018, April 2019. [PUMA: 2019 izi kontermann mueller] URL
A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.. JCO clinical cancer informatics, 3:1--17, American Society of Clinical Oncology, April 2019. [PUMA: 2019 izi morrison] URL
Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs, 19420862.2019.1603024, April 2019. [PUMA: 2019 izi kontermann] URL
Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc. mAbs, 1--13, Taylor & Francis, March 2019. [PUMA: 2019 izi kontermann pfizenmaier] URL
TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Cell Death & Differentiation, 1, Nature Publishing Group, March 2019. [PUMA: 2019 izi morrison myown] URL
Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma. BMC Cell Biology, (19)1:28, December 2019. [PUMA: 2019 izi morrison] URL
Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. npj Systems Biology and Applications, (4)1:39, December 2018. [PUMA: 2018 izi kontermann] URL
Preclinical efficacy of endoglin-targeting antibody-drug conjugates for the treatment of Ewing sarcoma. Clinical Cancer Research, clincanres.0936.2018, November 2018. [PUMA: 2018 izi kontermann] URL
Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism. Cell Death & Disease, (9)11:1112, November 2018. [PUMA: 2018 izi kontermann morrison] URL
Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death & Differentiation, 1, October 2018. [PUMA: 2018 izi morrison myown] URL
Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity. mAbs, 19420862.2018.1524664, September 2018. [PUMA: 2018 izi kontermann] URL
Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells. mAbs, 19420862.2018.1494105, July 2018. [PUMA: 2018 izi kontermann] URL
Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports, (8)1:13628, December 2018. [PUMA: 2018 izi kontermann] URL
Duokines: a novel class of dual-acting co-stimulatory molecules acting in cis or trans. OncoImmunology, (7)9:e1471442, Taylor & Francis, September 2018. [PUMA: 2018 izi kontermann] URL
The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function. Journal of Biological Chemistry, jbc.RA118.003787, July 2018. [PUMA: 2018 hausser izi olayioye] URL
A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions. eLife, (7)July 2018. [PUMA: 2018 hausser izi olayioye] URL
Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications. The FEBS Journal, July 2018. [PUMA: 2018 izi morrison] URL
Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLOS ONE, (13)6:1-19, Public Library of Science, June 2018. [PUMA: 2018 izi pollak scheuric] URL
m6A RNA Degradation Products are Catabolized by an Evolutionarily Conserved N6-methyl-AMP Deaminase in Plant and Mammalian Cells.. The Plant cell, tpc.00236.2018, American Society of Plant Biologists, June 2018. [PUMA: 2018 izi olayioye] URL