%0 Journal Article %1 ISI:000305279600002 %A Takors, R. %C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS %D 2012 %I ELSEVIER SCIENCE BV %J JOURNAL OF BIOTECHNOLOGY %K myown %N 1-2 %P 3-9 %R 10.1016/j.jbiotec.2011.12.010 %T Scale-up of microbial processes: Impacts, tools and open questions %U https://doi.org/10.1016/j.jbiotec.2011.12.010 %V 160 %X Industrial biotechnological production is developing rapidly worldwide. Consequently, more and novel bioprocesses need to perform optimally not only in small lab- but also in large production scales. This article shortly reviews typical impacts found when cells are exposed to micro environmental heterogeneities typically occurring in poorly mixed large scale production reactors. The current state-of-the-art of tool development is presented for analyzing these phenomena. Finally, still open questions are formulated and needs for future research are outlined to further support the expansion of biotech industries by successful research results. (C) 2011 Elsevier B.V. All rights reserved.

@article{ISI:000305279600002, abstract = {{Industrial biotechnological production is developing rapidly worldwide. Consequently, more and novel bioprocesses need to perform optimally not only in small lab- but also in large production scales. This article shortly reviews typical impacts found when cells are exposed to micro environmental heterogeneities typically occurring in poorly mixed large scale production reactors. The current state-of-the-art of tool development is presented for analyzing these phenomena. Finally, still open questions are formulated and needs for future research are outlined to further support the expansion of biotech industries by successful research results. (C) 2011 Elsevier B.V. All rights reserved.}}, added-at = {2018-06-08T11:35:23.000+0200}, address = {{PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}}, affiliation = {{Takors, R (Reprint Author), Univ Stuttgart, Inst Biochem Engn, Allmandring 31, D-70569 Stuttgart, Germany. Univ Stuttgart, Inst Biochem Engn, D-70569 Stuttgart, Germany.}}, author = {Takors, R.}, author-email = {{takors@ibvt.uni-stuttgart.de}}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2b975e9b8b24b00b7297d9e2924821b41/ralftakors}, da = {{2018-01-26}}, doc-delivery-number = {{958ZN}}, doi = {{10.1016/j.jbiotec.2011.12.010}}, interhash = {f29041b4ac4dfec9cfaf28348e9c2e02}, intrahash = {b975e9b8b24b00b7297d9e2924821b41}, issn = {{0168-1656}}, journal = {{JOURNAL OF BIOTECHNOLOGY}}, journal-iso = {{J. Biotechnol.}}, keywords = {myown}, keywords-plus = {{RECOMBINANT ESCHERICHIA-COLI; IN-VIVO KINETICS; INTRACELLULAR METABOLITE DYNAMICS; DISSOLVED-OXYGEN CONCENTRATION; SENSOR REACTOR APPROACH; FED-BATCH CULTIVATIONS; BAKER YEAST PRODUCTION; SACCHAROMYCES-CEREVISIAE; EXPERIMENTAL SIMULATION; FERMENTATION PROCESSES}}, language = {{English}}, month = {{JUL 31}}, number = {{1-2}}, number-of-cited-references = {{84}}, pages = {{3-9}}, publisher = {{ELSEVIER SCIENCE BV}}, research-areas = {{Biotechnology \& Applied Microbiology}}, times-cited = {{48}}, timestamp = {2018-06-08T09:35:23.000+0200}, title = {{Scale-up of microbial processes: Impacts, tools and open questions}}, type = {{Article}}, unique-id = {{ISI:000305279600002}}, url = {https://doi.org/10.1016/j.jbiotec.2011.12.010}, usage-count-last-180-days = {{3}}, usage-count-since-2013 = {{58}}, volume = {{160}}, web-of-science-categories = {{Biotechnology \& Applied Microbiology}}, year = {{2012}} }