Abstract
The interaction between the metal and the potentially o- or p-quinonoid topaquinone (TPQ) ligand in the active site of Cu-dependent amine oxidases was approached using (Qn-)Cun+(L), Q = 3,5-di-tert-butyl-o-benzoquinone and L = 1-alkyl-2-(methylthiomethyl)-1H-benzimidazole, as a first model system for the enzymically relevant and EPR-detectable valence tautomerism (n = 1 or 2). The data are preceded by a review of model systems related to the function and coupling of Cu metal and the org. cofactor in copper-dependent amine oxidases, including the use of 2,4,5-trihydroxytoluene as a model for TPQ. [on SciFinder(R)]
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