Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.
Description
Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth
%0 Journal Article
%1 chowdhury2008effect
%A Chowdhury, Arnab Roy
%A Zhao, Zhixing
%A Englund, Paul T.
%D 2008
%J Eukaryotic Cell
%K growth sync
%N 2
%P 425-428
%R 10.1128/EC.00369-07
%T Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth
%U http://ec.asm.org/content/7/2/425.abstract
%V 7
%X Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.
@article{chowdhury2008effect,
abstract = {Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.},
added-at = {2017-07-28T17:20:10.000+0200},
author = {Chowdhury, Arnab Roy and Zhao, Zhixing and Englund, Paul T.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2be4dcaa8dc236548ec6fb9f4159a96bb/robingarcia},
description = {Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth},
doi = {10.1128/EC.00369-07},
eprint = {http://ec.asm.org/content/7/2/425.full.pdf+html},
interhash = {31b290ec6848598639fd0e2047c8dab1},
intrahash = {be4dcaa8dc236548ec6fb9f4159a96bb},
journal = {Eukaryotic Cell},
keywords = {growth sync},
number = 2,
pages = {425-428},
timestamp = {2017-07-28T15:20:10.000+0200},
title = {Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth
},
url = {http://ec.asm.org/content/7/2/425.abstract},
volume = 7,
year = 2008
}