%0 Conference Paper %1 Witt2007 %A Witt, Johannes %A Husser, Sebastian %A Kulms, Dagmar %A Barisic, Sandra %A Sawodny, Oliver %A Sauter, Thomas %B Proceedings of the SICE Annual Conference %D 2007 %K 2007 izi kulms sauter %P 1353--1358 %R 10.1109/SICE.2007.4421193 %T Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence %U https://doi.org/10.1109/SICE.2007.4421193 %X NF-$\kappa$B dependent enhancement of UVB-induced apoptosis has recently been reported upon co-stimulation of cells with IL-1, together with a sustained absence of the NF-$\kappa$B inhibitor IKBOC. In order to investigate the behavior of I$\kappa$B$\alpha$, an ODE model for the IL-1 receptor is developed, coupled with an existing NF-$\kappa$B signaling module and parameterized using experimental and literature data. Functional dependencies between good fit parameters facilitate parameter identification for additional experimental data. The model is used to test and reject the hypothesis that the sustained absence of I$\kappa$B$\alpha$ upon IL-1+UVB stimulation is due to an altered internalization behavior of the IL-1 receptor. © 2007 SICE. %@ 4907764286

@inproceedings{Witt2007, abstract = {NF-$\kappa$B dependent enhancement of UVB-induced apoptosis has recently been reported upon co-stimulation of cells with IL-1, together with a sustained absence of the NF-$\kappa$B inhibitor IKBOC. In order to investigate the behavior of I$\kappa$B$\alpha$, an ODE model for the IL-1 receptor is developed, coupled with an existing NF-$\kappa$B signaling module and parameterized using experimental and literature data. Functional dependencies between good fit parameters facilitate parameter identification for additional experimental data. The model is used to test and reject the hypothesis that the sustained absence of I$\kappa$B$\alpha$ upon IL-1+UVB stimulation is due to an altered internalization behavior of the IL-1 receptor. {\textcopyright} 2007 SICE.}, added-at = {2023-06-29T13:07:55.000+0200}, author = {Witt, Johannes and Husser, Sebastian and Kulms, Dagmar and Barisic, Sandra and Sawodny, Oliver and Sauter, Thomas}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2b06b802c63be71124826bfc3f564a366/fabian}, booktitle = {Proceedings of the SICE Annual Conference}, doi = {10.1109/SICE.2007.4421193}, interhash = {807cf281961bb7ca58c7db4c390a3291}, intrahash = {b06b802c63be71124826bfc3f564a366}, isbn = {4907764286}, keywords = {2007 izi kulms sauter}, pages = {1353--1358}, timestamp = {2023-06-29T13:07:55.000+0200}, title = {{Modeling of IL-1 induced NF-κB signaling and analysis of additional UVB influence}}, url = {https://doi.org/10.1109/SICE.2007.4421193}, year = 2007 }