%0 Generic %1 wachlmayr2023supplementary %A Wachlmayr, Johann %A Fläschner, Gotthold %A Pluhackova, Kristyna %A Sandtner, Walter %A Siligan, Christine %A Horner, Andreas %D 2023 %K darus ubs_10021 ubs_20019 ubs_30165 unibibliografie %R 10.18419/darus-3390 %T Supplementary Material for 'Entropic barrier of water permeation through single-file channels' %X Facilitated water permeation through narrow biological channels is fundamental for all forms of life. This process involves dehydration of bulk water entering the single-file region and hydrogen bond formation with channel lining amino acid residues. Despite its significance in health and disease as well as for biotechnological applications the energetics of water permeation are still elusive. Whereas the enthalpic contribution to Gibbs free energy is readily accessible via temperature dependent water permeability measurements, estimation of the entropic contribution requires information on the temperature dependence of the rate of water permeation. By means of accurate activation energy measurements of water permeation through AQP1 and by determining the accurate single channel permeability we were, for the first time, able to estimate the entropic barrier of water permeation through a narrow biological channel. This is a first step in understanding the energetic contributions in various biological and artificial channels exhibiting vastly different pore geometries.

@misc{wachlmayr2023supplementary, abstract = {Facilitated water permeation through narrow biological channels is fundamental for all forms of life. This process involves dehydration of bulk water entering the single-file region and hydrogen bond formation with channel lining amino acid residues. Despite its significance in health and disease as well as for biotechnological applications the energetics of water permeation are still elusive. Whereas the enthalpic contribution to Gibbs free energy is readily accessible via temperature dependent water permeability measurements, estimation of the entropic contribution requires information on the temperature dependence of the rate of water permeation. By means of accurate activation energy measurements of water permeation through AQP1 and by determining the accurate single channel permeability we were, for the first time, able to estimate the entropic barrier of water permeation through a narrow biological channel. This is a first step in understanding the energetic contributions in various biological and artificial channels exhibiting vastly different pore geometries. }, added-at = {2023-07-17T10:07:39.000+0200}, affiliation = {Wachlmayr, Johann/Johannes Kepler University Linz, Fläschner, Gotthold/ETH Zürich, Pluhackova, Kristyna/Universität Stuttgart, Sandtner, Walter/Medical University of Vienna, Siligan, Christine/Johannes Kepler University Linz, Horner, Andreas/Johannes Kepler University Linz}, author = {Wachlmayr, Johann and Fläschner, Gotthold and Pluhackova, Kristyna and Sandtner, Walter and Siligan, Christine and Horner, Andreas}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/288c865b097090c7d6560e2df741b7002/unibiblio}, doi = {10.18419/darus-3390}, howpublished = {Dataset}, interhash = {6d0fb93088867d2b8cd85fcc9586c7c6}, intrahash = {88c865b097090c7d6560e2df741b7002}, keywords = {darus ubs_10021 ubs_20019 ubs_30165 unibibliografie}, note = {Related to: Wachlmayr, Johann; Fläschner, Gotthold; Pluhackova, Kristyna; Sandtner, Walter, Siliga, Christine; Horner, Andreas, "Entropic barrier of water permeation through single-file channels" Comms. Chem. 2023,. doi: 10.1038/s42004-023-00919-0}, orcid-numbers = {Wachlmayr, Johann/0000-0003-0222-3374, Fläschner, Gotthold/0000-0001-6707-6905, Pluhackova, Kristyna/0000-0002-7498-6584, Sandtner, Walter/0000-0003-3637-260X, Siligan, Christine/0000-0001-8294-1960, Horner, Andreas/0000-0002-5328-1745}, timestamp = {2023-07-17T10:07:39.000+0200}, title = {Supplementary Material for 'Entropic barrier of water permeation through single-file channels'}, year = 2023 }