Several studies have assigned catecholamines a pro-oxidant role and have therefore correlated catecholamines with the development of different pathophysiol. processes. This pro-oxidant effect could be due to the Fenton reaction (i.e., Fe(II) + H2O2 $\rightarrow$ Fe(III) + ·OH + OH-), which is known to be utilized by catecholamines to reduce Fe(III) and O2. The ability of a few catecholamines (i.e., dopamine, epinephrine and norepinephrine) to reduce Fe(III) to Fe(II) and O2 to H2O2 and to produce ·OH radicals by the Fenton reaction was evaluated at different pH values. The catecholamines were obsd. to produce Fe(II) and H2O2 at different pH values. Therefore, ·OH radical prodn. was enhanced at pH values where only Fe(III) redn. was obsd. At pH values near 7.0, the catecholamines did not enhance the prodn. of ·OH radicals. Instead, the catecholamines acted as antioxidants forming bis-complexes, i.e., Fe(LH)2+. The catecholamines sequestered iron from the reaction system and thereby prevented iron from reacting with other compds. such as H2O2. on SciFinder(R)
%0 Journal Article
%1 Melin.2016
%A Melin, Victoria
%A Henriquez, Adolfo
%A Radojkovic, Claudia
%A Schwederski, Brigitte
%A Kaim, Wolfgang
%A Freer, Juanita
%A Contreras, David.
%D 2016
%J Inorganica Chimica Acta
%K Fenton catecholamine dopamine epinephrine iron norepinephrine oxygen reaction redn
%P 1--7
%R 10.1016/j.ica.2016.07.044
%T Reduction reactivity of catecholamines and their ability to promote a Fenton reaction
%V 453
%X Several studies have assigned catecholamines a pro-oxidant role and have therefore correlated catecholamines with the development of different pathophysiol. processes. This pro-oxidant effect could be due to the Fenton reaction (i.e., Fe(II) + H2O2 $\rightarrow$ Fe(III) + ·OH + OH-), which is known to be utilized by catecholamines to reduce Fe(III) and O2. The ability of a few catecholamines (i.e., dopamine, epinephrine and norepinephrine) to reduce Fe(III) to Fe(II) and O2 to H2O2 and to produce ·OH radicals by the Fenton reaction was evaluated at different pH values. The catecholamines were obsd. to produce Fe(II) and H2O2 at different pH values. Therefore, ·OH radical prodn. was enhanced at pH values where only Fe(III) redn. was obsd. At pH values near 7.0, the catecholamines did not enhance the prodn. of ·OH radicals. Instead, the catecholamines acted as antioxidants forming bis-complexes, i.e., Fe(LH)2+. The catecholamines sequestered iron from the reaction system and thereby prevented iron from reacting with other compds. such as H2O2. on SciFinder(R)
@article{Melin.2016,
abstract = {Several studies have assigned catecholamines a pro-oxidant role and have therefore correlated catecholamines with the development of different pathophysiol. processes. This pro-oxidant effect could be due to the Fenton reaction (i.e., Fe(II) + H2O2 $\rightarrow$ Fe(III) + ·OH + OH-), which is known to be utilized by catecholamines to reduce Fe(III) and O2. The ability of a few catecholamines (i.e., dopamine, epinephrine and norepinephrine) to reduce Fe(III) to Fe(II) and O2 to H2O2 and to produce ·OH radicals by the Fenton reaction was evaluated at different pH values. The catecholamines were obsd. to produce Fe(II) and H2O2 at different pH values. Therefore, ·OH radical prodn. was enhanced at pH values where only Fe(III) redn. was obsd. At pH values near 7.0, the catecholamines did not enhance the prodn. of ·OH radicals. Instead, the catecholamines acted as antioxidants forming bis-complexes, i.e., [Fe(LH)2]+. The catecholamines sequestered iron from the reaction system and thereby prevented iron from reacting with other compds. such as H2O2. [on SciFinder(R)]},
added-at = {2019-07-15T13:41:23.000+0200},
author = {Melin, Victoria and Henriquez, Adolfo and Radojkovic, Claudia and Schwederski, Brigitte and Kaim, Wolfgang and Freer, Juanita and Contreras, David.},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/27590deb1ab160e6979ef756e094e0e1a/b_schwederski},
doi = {10.1016/j.ica.2016.07.044},
interhash = {29cb87fda66e100c7ea9cb66f52aa951},
intrahash = {7590deb1ab160e6979ef756e094e0e1a},
issn = {0020-1693},
journal = {Inorganica Chimica Acta},
keywords = {Fenton catecholamine dopamine epinephrine iron norepinephrine oxygen reaction redn},
pages = {1--7},
timestamp = {2019-07-15T11:42:10.000+0200},
title = {Reduction reactivity of catecholamines and their ability to promote a Fenton reaction},
volume = 453,
year = 2016
}
