%0 Journal Article %1 Kulms2006 %A Kulms, Dagmar %A Schwarz, Thomas %D 2006 %J Vitamins and Hormones %K 2006 izi kulms %P 283--300 %R 10.1016/S0083-6729(06)74011-0 %T NF-κB and Cytokines %U https://www.ncbi.nlm.nih.gov/pubmed/17027519 %V 74 %X Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-$\kappa$B (NF-$\kappa$B). NF-$\kappa$B is a ubiquitous transcription factor which is crucially involved in many biological processes, including tissue development and maintenance of tissue homeostasis. NF-$\kappa$B also controls apoptotic cell death of both normal and malignant cells. Thus, it is a challenging target for anticancer and anti-inflammatory strategies. However, it has been recognized that NF-$\kappa$B does not only influence many biological processes but also under certain conditions the activities of NF-$\kappa$B can be altered as well, for example, by cytokines. This cross talk needs to be taken into account when developing strategies targeting NF-$\kappa$B for anticancer therapy. © 2006 Elsevier Inc. All rights reserved. %Z Kulms, DagmarSchwarz, ThomasengReviewVitam Horm. 2006;74:283-300. doi: 10.1016/S0083-6729(06)74011-0. %7 2006/10/10 %@ 0127098747

@article{Kulms2006, abstract = {Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-$\kappa$B (NF-$\kappa$B). NF-$\kappa$B is a ubiquitous transcription factor which is crucially involved in many biological processes, including tissue development and maintenance of tissue homeostasis. NF-$\kappa$B also controls apoptotic cell death of both normal and malignant cells. Thus, it is a challenging target for anticancer and anti-inflammatory strategies. However, it has been recognized that NF-$\kappa$B does not only influence many biological processes but also under certain conditions the activities of NF-$\kappa$B can be altered as well, for example, by cytokines. This cross talk needs to be taken into account when developing strategies targeting NF-$\kappa$B for anticancer therapy. {\textcopyright} 2006 Elsevier Inc. All rights reserved.}, added-at = {2018-02-01T16:29:42.000+0100}, annote = {Kulms, DagmarSchwarz, ThomasengReviewVitam Horm. 2006;74:283-300. doi: 10.1016/S0083-6729(06)74011-0.}, author = {Kulms, Dagmar and Schwarz, Thomas}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2134c917f5abfc29280a04b582a34ab23/cristiano}, doi = {10.1016/S0083-6729(06)74011-0}, edition = {2006/10/10}, interhash = {261c988c62028a8ac7354e18f7cce8de}, intrahash = {134c917f5abfc29280a04b582a34ab23}, isbn = {0127098747}, issn = {00836729}, journal = {Vitamins and Hormones}, keywords = {2006 izi kulms}, pages = {283--300}, pmid = {17027519}, timestamp = {2018-07-25T12:32:54.000+0200}, title = {{NF-κB and Cytokines}}, url = {https://www.ncbi.nlm.nih.gov/pubmed/17027519}, volume = 74, year = 2006 }