Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a dominant mutation, the selective DNA methylation of the mutant allele could be used to repress its expression but retain the functionality of the normal gene.
%0 Journal Article
%1 Rajaram2023
%A Rajaram, Nivethika
%A Kouroukli, Alexandra G.
%A Bens, Susanne
%A Bashtrykov, Pavel
%A Jeltsch, Albert
%D 2023
%J Epigenetics & Chromatin
%K ajeltsch ibtb-bc imported myown unibibliografie
%N 1
%P 41
%R 10.1186/s13072-023-00515-5
%T Development of super-specific epigenome editing by targeted allele-specific DNA methylation
%U https://doi.org/10.1186/s13072-023-00515-5
%V 16
%X Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a dominant mutation, the selective DNA methylation of the mutant allele could be used to repress its expression but retain the functionality of the normal gene.
@article{Rajaram2023,
abstract = {Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the target locus. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a dominant mutation, the selective DNA methylation of the mutant allele could be used to repress its expression but retain the functionality of the normal gene.},
added-at = {2023-11-14T18:54:34.000+0100},
author = {Rajaram, Nivethika and Kouroukli, Alexandra G. and Bens, Susanne and Bashtrykov, Pavel and Jeltsch, Albert},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/208bc6738a1f8436a0d665025ba6a82f4/ajeltsch},
day = 21,
doi = {10.1186/s13072-023-00515-5},
interhash = {99c59d49f371e1ce135bd8305b64e265},
intrahash = {08bc6738a1f8436a0d665025ba6a82f4},
issn = {1756-8935},
journal = {Epigenetics {\&} Chromatin},
keywords = {ajeltsch ibtb-bc imported myown unibibliografie},
month = oct,
number = 1,
pages = 41,
timestamp = {2023-11-14T18:54:34.000+0100},
title = {Development of super-specific epigenome editing by targeted allele-specific DNA methylation},
url = {https://doi.org/10.1186/s13072-023-00515-5},
volume = 16,
year = 2023
}
