Publications

Jeannine Diesch, Marguerite-Marie Le Pannérer, René Winkler, Raquel Casquero, Matthias Muhar, Mark van der Garde, Michael Maher, Carolina Martínez Herráez, Joan J. Bech-Serra, Michaela Fellner, Philipp Rathert, Nigel Brooks, Lurdes Zamora, Antonio Gentilella, Carolina de la Torre, Johannes Zuber, Katharina S. Götze, and Marcus Buschbeck. Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. Nature Communications, (12)1:6060, Oct 18, 2021. [PUMA: ibtb-bc myown philipprathert] URL

Tabea L. Bauer, Katrin Collmar, Till Kaltofen, Ann-Katrin Loeffler, Lorena Decker, Jan Mueller, Sabine Pinter, Stephan A. Eisler, Sven Mahner, Patricia Fraungruber, Stefan Kommoss, Annette Staebler, Lewis Francis, R. Steven Conlan, Johannes Zuber, Udo Jeschke, Fabian Trillsch, and Philipp Rathert. Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development. Cancers, (13)15:3801, MDPI AG, July 2021. [PUMA: ibtb-bc myown philipprathert] URL

S. Pinter, F. Knodel, M. Choudalakis, P. Schnee, C. Kroll, M. Fuchs, A. Broehm, S. Weirich, M. Roth, S. A. Eisler, J. Zuber, A. Jeltsch, and P. Rathert. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation. Nucleic Acids Res, (49)8:4350-4370, 2021. [PUMA: ibtb-bc myown philipprathert] URL

Philipp Rathert. Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase. Life, (11)8:726, MDPI, 2021. [PUMA: ibtb-bc myown philipprathert]

Philipp Rathert Carolin Kroll. Stable Expression of Epigenome Editors via Viral Delivery and Genomic Integration. Methods in Molecular Biology, 1767:215-225, 2018. [PUMA: ibtb-bc myown philipprathert]

M. Emperle, S. Adam, S. Kunert, M. Dukatz, A. Baude, C. Plass, P. Rathert, P. Bashtrykov, and A. Jeltsch. Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns. Nucleic Acids Res, (47)21:11355-11367, 2019. [PUMA: ibtb-bc myown philipprathert] URL

J. Broche, G. Kungulovski, P. Bashtrykov, P. Rathert, and A. Jeltsch. Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing. Nucleic Acids Res, Oxford University Press (OUP), December 2020. [PUMA: ibtb-bc myown philipprathert] URL

Philipp Rathert, Mareike Roth, Tobias Neumann, Felix Muerdter, Jae-Seok Roe, Matthias Muhar, Sumit Deswal, Sabine Cerny-Reiterer, Barbara Peter, Julian Jude, Thomas Hoffmann, Łukasz M. Boryń, Elin Axelsson, Norbert Schweifer, Ulrike Tontsch-Grunt, Lukas E. Dow, Davide Gianni, Mark Pearson, Peter Valent, Alexander Stark, Norbert Kraut, Christopher R. Vakoc, and Johannes Zuber. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature, (525)7570:543--547, Springer Science and Business Media LLC, September 2015. [PUMA: ibtb-bc myown philipprathert] URL

Ina Bock, Arunkumar Dhayalan, Srikanth Kudithipudi, Ole Brandt, Philipp Rathert, and Albert Jeltsch. Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics, (6)2:256-263, Landes Bioscience, 2011. [PUMA: ibtb-bc myown philipprathert]

Rachna Goyal, Philipp Rathert, Heike Laser, Humaira Gowher, and Albert Jeltsch. Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics, (2)3:155-160, Landes Bioscience, 2007. [PUMA: ibtb-bc myown philipprathert]

Cristiana Lungu, Sabine Pinter, Julian Broche, Philipp Rathert, and Albert Jeltsch. Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites. Nature Communications, (8)Nature Publishing Group UK, London, 2017. [PUMA: ibtb-bc myown philipprathert] URL

Arunkumar Dhayalan, Emilia Dimitrova, Philipp Rathert, and Albert Jeltsch. A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. Journal of Biomolecular Screening, (14)9:1129-1133, Sage, 2009. [PUMA: ibtb-bc myown philipprathert]

Sara Sdelci, André F. Rendeiro, Philipp Rathert, Wanhui You, Jung-Ming G. Lin, Anna Ringler, Gerald Hofstätter, Herwig P. Moll, Bettina Gürtl, Matthias Farlik, Sandra Schick, Freya Klepsch, Matthew Oldach, Pisanu Buphamalai, Fiorella Schischlik, Peter Májek, Katja Parapatics, Christian Schmidl, Michael Schuster, Thomas Penz, Dennis L. Buckley, Otto Hudecz, Richard Imre, Shuang-Yan Wang, Hans Michael Maric, Robert Kralovics, Keiryn L. Bennett, André C. Müller, Karl Mechtler, Jörg Menche, James E. Bradner, Georg E. Winter, Kristaps Klavins, Emilio Casanova, Christoph Bock, Johannes Zuber, and Stefan Kubicek. MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nature Genetics, (51)6:990–998, Nature Publishing Group, 2019. [PUMA: ibtb-bc myown philipprathert]

Arumugam Rajavelu, Cristiana Lungu, Max Emperle, Michael Dukatz, Alexander Bröhm, Julian Broche, Ines Hanelt, Edris Parsa, Sarah Schiffers, Rahul Karnik, Alexander Meissner, Thomas Carell, Philipp Rathert, Renata Z. Jurkowska, and Albert Jeltsch. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Research, (46)17:9044-9056, 2018. [PUMA: ibtb-bc myown philipprathert] URL

Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, James Bennett, Philipp Rathert, Michael Schuster, Thomas Penz, Oleg Fedorov, Giulio Superti-Furga, Christoph Bock, Johannes Zuber, Kilian V. M. Huber, Stefan Knapp, Susanne Muller, and Stefan Kubicek. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nature chemical biology, (12)7:504–510, Nature Publishing Group, 2016. [PUMA: ibtb-bc myown philipprathert]

Philipp Rathert, Arunkumar Dhayalan, Marie Murakami, Xing Zhang, Raluca Tamas, Renata Jurkowska, Yasuhiko Komatsu, Yoichi Shinkai, Xiaodong Cheng, and Albert Jeltsch. Protein lysine methyltransferase G9a acts on non-histone targets. Nature Chemical Biology, (4)6:344-346, Nature Publishing Group, 2008. [PUMA: ibtb-bc myown philipprathert]

Yingying Zhang, Renata Jurkowska, Szabolcs Soeroes, Arumugam Rajavelu, Arunkumar Dhayalan, Ina Bock, Philipp Rathert, Ole Brandt, Richard Reinhardt, Wolfgang Fischle, and Albert Jeltsch. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Research, (38)13:4246-4253, Oxford Univ. Press, 2010. [PUMA: ibtb-bc myown philipprathert]

Wolfgang Sebastian Lieb, Cristiana Lungu, Raluca Tamas, Hannah Berreth, Philipp Rathert, Peter Storz, Monilola A. Olayioye, and Angelika Hausser. The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells. International Journal of Cancer, ijc.32798, John Wiley & Sons, Ltd, November 2019. [PUMA: ibtb-bc myown philipprathert] URL

Philipp Rathert, Tamás Raskó, Markus Roth, Krystyna Ślaska-Kiss, Alfred Pingoud, Antal Kiss, and Albert Jeltsch. Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. ChemBioChem, (8)2:202-207, Wiley-VCH, 2007. [PUMA: ibtb-bc myown philipprathert]

Arunkumar Dhayalan, Arumugam Rajavelu, Philipp Rathert, Raluca Tamas, Renata Jurkowska, Sergey Ragozin, and Albert Jeltsch. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. Journal of Biological Chemistry, (285)34:26114-26120, American Society for Biochemistry and Molecular Biology, 2010. [PUMA: ibtb-bc myown philipprathert]