Publications

Cristiano Guttà, Christoph Morhard, and Markus Rehm. Applying a GAN-based classifier to improve transcriptome-based prognostication in breast cancer. PLOS Computational Biology, (19)4:1-20, Public Library of Science, April 2023. [PUMA: 2023 EXC2075 izi morrison myown pn2 simtech] URL

Cristiano Guttà, Christoph Morhard, and Markus Rehm. T-GAN-D: a GAN-based classifier for breast cancer prognostication. Zenodo, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL

Cristiano Guttà, Christoph Morhard, and Markus Rehm. Applying GAN-based data augmentation to improve transcriptome-based prognostication in breast cancer. medRxiv, Cold Spring Harbor Laboratory Press, October 2022. [PUMA: 2022 EXC2075 izi morrison myown pn2 simtech] URL

Julio Vera, Xin Lai, Andreas Baur, Michael Erdmann, Shailendra Gupta, Cristiano Guttà, Lucie Heinzerling, Markus V Heppt, Philipp Maximilian Kazmierczak, Manfred Kunz, Christopher Lischer, Brigitte M Pützer, Markus Rehm, Christian Ostalecki, Jimmy Retzlaff, Stephan Witt, Olaf Wolkenhauer, and Carola Berking. Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence. Briefings in Bioinformatics, October 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Chiara Boccellato, and Markus Rehm. Glioblastoma, from disease understanding towards optimal cell-based in vitro models. Cellular Oncology, Jun 28, 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Agnieszka H. Ludwig-Słomczyńska, and Markus Rehm. Mitochondrial genome variations, mitochondrial-nuclear compatibility, and their association with metabolic diseases. Obesity, John Wiley & Sons, Ltd, May 2022. [PUMA: 2022 EXC2075 izi morrison pn2 simtech] URL

Cathrin Hagenlocher, Robin Siebert, Bruno Taschke, Senait Wieske, Angelika Hausser, and Markus Rehm. ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discovery, (8)1:34, Jan 24, 2022. [PUMA: 2022 EXC2075 hausser izi morrison pn2 simtech] URL

Wolfgang Ehlers, Markus Morrison (Rehm), Patrick Schröder, Daniela Stöhr, and Arndt Wagner. Multiphasic modelling and computation of metastatic lung-cancer cell proliferation and atrophy in brain tissue based on experimental data. Biomechanics and Modeling in Mechanobiology, 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Nivetha Krishna Moorthy, Oliver Seifert, Stephan Eisler, Sara Weirich, Roland E. Kontermann, Markus Rehm, and Gavin Fullstone. Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma. Molecules 2021, Vol. 26, Page 7582, (26)24:7582, Multidisciplinary Digital Publishing Institute, December 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Nadine Pollak, Aline Lindner, Dirke Imig, Karsten Kuritz, Jacques S Fritze, Lorena Decker, Isabel Heinrich, Jannis Stadager, Stephan Eisler, Daniela Stöhr, Frank Allgöwer, Peter Scheurich, and Markus Rehm. Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis. Journal of cell science, jcs.258966--, England, November 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Christian T. Hellwig, M. Eugenia Delgado, Josip Skoko, Lydia Dyck, Carol Hanna, Alexa Wentges, Claudia Langlais, Cathrin Hagenlocher, Alexandra Mack, David Dinsdale, Kelvin Cain, Marion MacFarlane, and Markus Rehm. Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death & Differentiation 2021, 1--9, Nature Publishing Group, August 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Juric, Gavin Fullstone, Maïté Verreault, Ahmed Idbaih, Martine L. M. Lamfers, Brona M. Murphy, and Markus Rehm. Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist. Cell Death & Disease, (12)7:647, Nature Publishing Group, July 2021. [PUMA: 2021 EXC2075 izi morrison pn2 simtech] URL

Daniela Stöhr, and Markus Rehm. Linking hyperosmotic stress and apoptotic sensitivity. The FEBS Journal, febs.15520, Blackwell Publishing Ltd, August 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Dirke Imig, Nadine Pollak, Frank Allgöwer, and Markus Rehm. Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis. PLOS Computational Biology, (16)6:1-17, Public Library of Science, June 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Daniela Stöhr, Jens O. Schmid, Tobias B. Beigl, Alexandra Mack, Daniela S. Maichl, Kai Cao, Beate Budai, Gavin Fullstone, Roland E. Kontermann, Thomas E. Mürdter, Stephen W. G. Tait, Cathrin Hagenlocher, Nadine Pollak, Peter Scheurich, and Markus Rehm. Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Gavin Fullstone, Tabea L. Bauer, Cristiano Guttà, Manuela Salvucci, Jochen H. M. Prehn, and Markus Rehm. The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell Death & Differentiation, 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL

Gavin Fullstone, Cristiano Guttà, Amatus Beyer, and Markus Rehm. The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling. npj Systems Biology and Applications, (6)1:10--, 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Karsten Kuritz, Daniela Stöhr, Daniela Simone Maichl, Nadine Pollak, Markus Rehm, and Frank Allgöwer. Reconstructing temporal and spatial dynamics from single-cell pseudotime using prior knowledge of real scale cell densities. Scientific Reports, (10)1:3619, Nature Publishing Group, December 2020. [PUMA: 2020 EXC2075 izi morrison pn2 simtech] URL

Vesna Vetma, Cristiano Guttà, Nathalie Peters, Christian Praetorius, Meike Hutt, Oliver Seifert, Friedegund Meier, Roland Kontermann, Dagmar Kulms, and Markus Rehm. Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism. Cell Death & Differentiation 2020, 1--16, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL

Cristiano Guttà, Arman Rahman, Claudia Aura, Peter Dynoodt, Emilie M. Charles, Elodie Hirschenhahn, Jesuchristopher Joseph, Jasper Wouters, Ciaran de Chaumont, Mairin Rafferty, Madhuri Warren, Joost J. van den Oord, William M. Gallagher, and Markus Rehm. Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell Death & Disease, (11)2:124, Nature Publishing Group, February 2020. [PUMA: 2020 EXC2075 izi morrison myown pn2 simtech] URL