Publications

A. Jeltsch, J. Broche, and P. Bashtrykov. Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes. Genes (Basel), (10)5:388, 2019. [PUMA: ajeltsch ibtb-bc imported myown pbashtrykov unibiblio unibibliografie] URL

S. Adam, H. Anteneh, M. Hornisch, V. Wagner, J. Lu, N. E. Radde, P. Bashtrykov, J. Song, and A. Jeltsch. DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nat. Communications, (11)1:3723, 2020. [PUMA: ajeltsch ibtb-bc imported myown pbashtrykov unibiblio unibibliografie] URL

J. Broche, G. Kungulovski, P. Bashtrykov, P. Rathert, and A. Jeltsch. Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing. Nucleic Acids Res, (49)1:158-176, 2021. [PUMA: ajeltsch ibtb-bc imported myown pbashtrykov unibiblio unibibliografie] URL

P. Bashtrykov, A. Rajavelu, B. Hackner, S. Ragozin, T. Carell, and A. Jeltsch. Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain. Chembiochem, (15)5:743-8, 2014. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, G. Jankevicius, R. Z. Jurkowska, S. Ragozin, and A. Jeltsch. The UHRF1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase DNMT1 by an allosteric mechanism. J Biol Chem, (289)7:4106-15, 2014. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

M. Dukatz, S. Adam, M. Biswal, J. Song, P. Bashtrykov, and A. Jeltsch. Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Nucleic Acids Res, (48)20:11495-11509, 2020. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

D. Hofacker, J. Broche, L. Laistner, S. Adam, P. Bashtrykov, and A. Jeltsch. Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects. Int J Mol Sci, (21)22020. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, and A. Jeltsch. DNA Methylation Analysis by Bisulfite Conversion Coupled to Double Multiplexed Amplicon-Based Next-Generation Sequencing (NGS). Methods Mol Biol, (1767):367-382, 2018. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

A. Jeltsch, J. Broche, C. Lungu, and P. Bashtrykov. Biotechnological Applications of MBD Domain Proteins for DNA Methylation Analysis. J Mol Biol, 2019. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, and A. Jeltsch. Epigenome Editing in the Brain. Adv Exp Med Biol, (978):409-424, 2017. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

M. Dukatz, K. Holzer, M. Choudalakis, M. Emperle, C. Lungu, P. Bashtrykov, and A. Jeltsch. H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction. J Mol Biol, (431)24:5063-5074, 2019. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

O. Engmann, B. Labonte, A. Mitchell, P. Bashtrykov, E. S. Calipari, C. Rosenbluh, Y. E. Loh, D. M. Walker, D. Burek, P. J. Hamilton, O. Issler, R. L. Neve, G. Turecki, Y. Hurd, A. Chess, L. Shen, I. Mansuy, A. Jeltsch, S. Akbarian, and E. J. Nestler. Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry, (82)11:794-805, 2017. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

A. Ceccaldi, A. Rajavelu, S. Ragozin, C. Senamaud-Beaufort, P. Bashtrykov, N. Testa, H. Dali-Ali, C. Maulay-Bailly, S. Amand, D. Guianvarc'h, A. Jeltsch, and P. B. Arimondo. Identification of novel inhibitors of DNA methylation by screening of a chemical library. ACS Chem Biol, (8)3:543-8, 2013. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, and A. Jeltsch. DNMT1-associated DNA methylation changes in cancer. Cell Cycle, (14)1:5, 2015. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

M. Hassanzadeh, R. Kasymov, S. Mahernia, M. Adib, M. Emperle, M. Dukatz, P. Bashtrykov, A. Jeltsch, and M. Amanlou. Discovery of Novel and Selective DNA Methyltransferase 1 Inhibitors by Pharmacophore and Docking-Based Virtual Screening. Chemistryselect, (2)27:8383-8392, 2017. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, G. Jankevicius, A. Smarandache, R. Z. Jurkowska, S. Ragozin, and A. Jeltsch. Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chem Biol, (19)5:572-8, 2012. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

A. Jeltsch, J. Broche, and P. Bashtrykov. Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes. Genes (Basel), (9)112018. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

L. Gao, M. Emperle, Y. Guo, S. A. Grimm, W. Ren, S. Adam, H. Uryu, Z. M. Zhang, D. Chen, J. Yin, M. Dukatz, H. Anteneh, R. Z. Jurkowska, J. Lu, Y. Wang, P. Bashtrykov, P. A. Wade, G. G. Wang, A. Jeltsch, and J. Song. Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, (11)1:3355, 2020. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

P. Bashtrykov, and A. Jeltsch. Allele-Specific Epigenome Editing. Methods Mol Biol, (1767):137-146, 2018. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL

M. Emperle, S. Adam, S. Kunert, M. Dukatz, A. Baude, C. Plass, P. Rathert, P. Bashtrykov, and A. Jeltsch. Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns. Nucleic Acids Res, (47)21:11355-11367, 2019. [PUMA: ajeltsch ibtb-bc imported pbashtrykov unibibliografie myown unibiblio] URL