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         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/29723d6ce30daaf4910269ea54837c2d7/bastian",         
         "tags" : [
            "Bacterial","Biomass,","Biosynthetic","Complex,","Corynebacterium","Dehydrogenase","Engineering,","Expression,","Fermentation","Gene","Genetic","Ketol-Acid","Oxidoreductases,","Pathways,","Proteins,","Pyruvate","Reductoisomerase,","Transaminases,","Valine,","glutamicum,","myown"
         ],
         
         "intraHash" : "9723d6ce30daaf4910269ea54837c2d7",
         "interHash" : "e1d424fe4d9f617e1a0837a7567bea3a",
         "label" : "Corynebacterium glutamicum tailored for high-yield L-valine production",
         "user" : "bastian",
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         "date" : "2018-02-09 13:18:17",
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         "pub-type": "article",
         "journal": "Appl. Microbiol. Biotechnol.",
         "year": "2008", 
         "url": "", 
         
         "author": [ 
            "Bastian Blombach","Mark E. Schreiner","Tobias Bartek","Marco Oldiges","Bernhard J. Eikmanns"
         ],
         "authors": [
         	
            	{"first" : "Bastian",	"last" : "Blombach"},
            	{"first" : "Mark E.",	"last" : "Schreiner"},
            	{"first" : "Tobias",	"last" : "Bartek"},
            	{"first" : "Marco",	"last" : "Oldiges"},
            	{"first" : "Bernhard J.",	"last" : "Eikmanns"}
         ],
         "volume": "79","number": "3","pages": "471--479","abstract": "We recently engineered the wild type of Corynebacterium glutamicum for the growth-decoupled production of L: -valine from glucose by inactivation of the pyruvate dehydrogenase complex and additional overexpression of the ilvBNCE genes, encoding the L-valine biosynthetic enzymes acetohydroxyacid synthase, isomeroreductase, and transaminase B. Based on the first generation of pyruvate-dehydrogenase-complex-deficient C. glutamicum strains, a second generation of high-yield L-valine producers was constructed by successive deletion of the genes encoding pyruvate:quinone oxidoreductase, phosphoglucose isomerase, and pyruvate carboxylase and overexpression of ilvBNCE. In fed-batch fermentations at high cell densities, the newly constructed strains produced up to 410 mM (48 g/l) L-valine, showed a maximum yield of 0.75 to 0.86 mol/mol (0.49 to 0.56 g/g) of glucose in the production phase and, in contrast to the first generation strains, excreted neither pyruvate nor any other by-product tested.",
         "pmid" : "18379776",
         
         "issn" : "0175-7598",
         
         "language" : "eng",
         
         "doi" : "10.1007/s00253-008-1444-z",
         
         "bibtexKey": "blombach_corynebacterium_2008"

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