{ "types" : { "Bookmark" : { "pluralLabel" : "Bookmarks" }, "Publication" : { "pluralLabel" : "Publications" }, "GoldStandardPublication" : { "pluralLabel" : "GoldStandardPublications" }, "GoldStandardBookmark" : { "pluralLabel" : "GoldStandardBookmarks" }, "Tag" : { "pluralLabel" : "Tags" }, "User" : { "pluralLabel" : "Users" }, "Group" : { "pluralLabel" : "Groups" }, "Sphere" : { "pluralLabel" : "Spheres" } }, "properties" : { "count" : { "valueType" : "number" }, "date" : { "valueType" : "date" }, "changeDate" : { "valueType" : "date" }, "url" : { "valueType" : "url" }, "id" : { "valueType" : "url" }, "tags" : { "valueType" : "item" }, "user" : { "valueType" : "item" } }, "items" : [ { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2a8704533a8dfa10f1d5f42ed6d4aef19/slegewie", "tags" : [ "Animals,","Base","Development,","Drosophila","Embryonic","Expression","Gene","Genetic,","Glucose,","Kinetics,","Messenger,","Proteins,","Proteome,","RNA,","Regulation,","Sequence,","Transcription,","Transcriptome","melanogaster," ], "intraHash" : "a8704533a8dfa10f1d5f42ed6d4aef19", "interHash" : "42325feb1689d483604c5222faf8ebb8", "label" : "Quantifying post-transcriptional regulation in the development of Drosophila melanogaster", "user" : "slegewie", "description" : "", "date" : "2025-03-05 15:52:38", "changeDate" : "2025-03-05 15:52:38", "count" : 1, "pub-type": "article", "journal": "Nature Communications", "year": "2018", "url": "", "author": [ "Kolja Becker","Alina Bluhm","Nuria Casas-Vila","Nadja Dinges","Mario Dejung","Sergi Sayols","Clemens Kreutz","Jean-Yves Roignant","Falk Butter","Stefan Legewie" ], "authors": [ {"first" : "Kolja", "last" : "Becker"}, {"first" : "Alina", "last" : "Bluhm"}, {"first" : "Nuria", "last" : "Casas-Vila"}, {"first" : "Nadja", "last" : "Dinges"}, {"first" : "Mario", "last" : "Dejung"}, {"first" : "Sergi", "last" : "Sayols"}, {"first" : "Clemens", "last" : "Kreutz"}, {"first" : "Jean-Yves", "last" : "Roignant"}, {"first" : "Falk", "last" : "Butter"}, {"first" : "Stefan", "last" : "Legewie"} ], "volume": "9","number": "1","pages": "4970","abstract": "Even though proteins are produced from mRNA, the correlation between mRNA levels and protein abundances is moderate in most studies, occasionally attributed to complex post-transcriptional regulation. To address this, we generate a paired transcriptome/proteome time course dataset with 14 time points during Drosophila embryogenesis. Despite a limited mRNA-protein correlation (ρ\u2009=\u20090.54), mathematical models describing protein translation and degradation explain 84\\% of protein time-courses based on the measured mRNA dynamics without assuming complex post transcriptional regulation, and allow for classification of most proteins into four distinct regulatory scenarios. By performing an in-depth characterization of the putatively post-transcriptionally regulated genes, we postulate that the RNA-binding protein Hrb98DE is involved in post-transcriptional control of sugar metabolism in early embryogenesis and partially validate this hypothesis using Hrb98DE knockdown. In summary, we present a systems biology framework for the identification of post-transcriptional gene regulation from large-scale, time-resolved transcriptome and proteome data.", "language" : "eng", "pmid" : "30478415", "file" : "Volltext:C\\:\\\\Users\\\\SL\\\\Zotero\\\\storage\\\\U4MU6BPV\\\\Becker et al. - 2018 - Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.pdf:application/pdf", "issn" : "2041-1723", "pmcid" : "PMC6255845", "doi" : "10.1038/s41467-018-07455-9", "bibtexKey": "becker_quantifying_2018" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/22b588a1576f9d267f8b73a0efdc931e9/kmeliani", "tags" : [ "Baden-Württemberg,","Basic","Individual","Migrant","Transition","and","background,","competence","development","development,","professional","system" ], "intraHash" : "2b588a1576f9d267f8b73a0efdc931e9", "interHash" : "90992b4c9fdb47fdb84a2979e4f19b42", "label" : "Die Entwicklung allgemeiner und berufsfachlicher Kompetenzen von Jugendlichen mit und ohne Migrationshintergrund im Übergangssystem unter den Bedingungen individueller Förderung.", "user" : "kmeliani", "description" : "", "date" : "2024-12-17 11:38:12", "changeDate" : "2024-12-17 11:38:12", "count" : 1, "pub-type": "article", "journal": "Unterrichtswissenschaft (Weinheim)", "year": "2018", "url": "https://doi.org/10.1007/s42010-017-0009-1", "author": [ "Reinhold Nickolaus","Svitlana Mokhonko","Stefan Behrendt","Dinah Vetter","Kim Méliani" ], "authors": [ {"first" : "Reinhold", "last" : "Nickolaus"}, {"first" : "Svitlana", "last" : "Mokhonko"}, {"first" : "Stefan", "last" : "Behrendt"}, {"first" : "Dinah", "last" : "Vetter"}, {"first" : "Kim", "last" : "Méliani"} ], "number": "1","pages": "61-85","abstract": "Zusammenfassung In der vorliegenden Studie wurden Kompetenzentwicklungen in einem Experimental‑/Kontrollgruppendesign unter Einbezug der tradierten Schulformen des Übergangssystems (VAB, BEJ, 2BFS) und zwei neuen Schulversuchsformen (AVdual, BFPE) untersucht. Dabei sollte u. a. überprüft werden, inwieweit die Schulform, auch angesichts des speziellen Förderbedarfs der Jugendlichen mit Migrationshintergrund, Einfluss auf die Kompetenzentwicklung in den Basiskompetenzen (Lesen, Mathematik) und den berufsfachlichen Kompetenzen (Metall, Hauswirtschaft) hat. Die Ergebnisse zeigen im berufsfachlichen Bereich und in Mathematik, nicht zuletzt in den Versuchsschulen, Matthäuseffekte und im Vergleich mit der 2BFS Vorteile für die 2BFS. Im Globalvergleich der EG und KG ergeben sich keine signifikanten Unterschiede. Im Lesen ergeben sich überwiegend nur im unteren Terzil Leistungszuwächse, lediglich in der AVdual profitieren auch die Leistungsstarken. Jugendliche mit Migrationshintergrund münden in allen Fächern mit schwächeren Leistungen ein und entwickeln sich, abgesehen von Mathematik, unterdurchschnittlich.", "issn" : "0340-4099", "bibtexKey": "article" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2b7d3fdabb6f4e75e6706e3635c5b1047/isw-bibliothek", "tags" : [ "ISW","Sheet","development,","forming,","integration,","metal","process","tool","transformability,","welding" ], "intraHash" : "b7d3fdabb6f4e75e6706e3635c5b1047", "interHash" : "64c926d120e259b5fb9840e3c38dfd1c", "label" : "On The Development Of Transformable Sheet Metal Forming Tools: On The Development Of Transformable Sheet Metal Forming Tools", "user" : "isw-bibliothek", "description" : "", "date" : "2016-03-03 09:53:12", "changeDate" : "2016-03-03 09:18:35", "count" : 1, "pub-type": "misc", "year": "2013", "url": "", "author": [ "Birkhold M.","Pauli F.-B.","Lechler A.","Verl A." ], "authors": [ {"first" : "Birkhold", "last" : "M."}, {"first" : "Pauli", "last" : "F.-B."}, {"first" : "Lechler", "last" : "A."}, {"first" : "Verl", "last" : "A."} ], "pages": "--","abstract": "Freed from the strict sinusoidal motion of classic mechanical presses, the servo press allows new tool designs. This free motion capability of the servo press can be used to integrate follow up processes into the sheet metal forming tool. With this approach, specialized equipment like dedicated welding stations become unnecessary. Moreover, by introducing transformability to the design, this integration can be made reversible. Depending on the production situation, it is possible to run the process integrated or externally. This tool design allows the manufacturer to adapt to demand more easily, thus increasing its competitiveness. However the complexity of such sheet metal forming tools is significantly increased. Thus tool manufacturers have yet to embrace the new capabilities of the servo press. In this paper we will show the design for a transformable sheet metal forming tool. The tool will produce a clamp, consisting of a ring and a holder. Ring and holder are formed, combined and welded within the tool. We will discuss the issues concerning mechanical and control systems design and how we have solved them. We will put a special emphasis on the challenges we faced with handling of forming parts, synchronization, placement and power supply of the integrated welding station.", "__markedentry" : "[xtl:6]", "bibtexKey": "M.F.-B.A.EtAl2013" } ] }