{ "types" : { "Bookmark" : { "pluralLabel" : "Bookmarks" }, "Publication" : { "pluralLabel" : "Publications" }, "GoldStandardPublication" : { "pluralLabel" : "GoldStandardPublications" }, "GoldStandardBookmark" : { "pluralLabel" : "GoldStandardBookmarks" }, "Tag" : { "pluralLabel" : "Tags" }, "User" : { "pluralLabel" : "Users" }, "Group" : { "pluralLabel" : "Groups" }, "Sphere" : { "pluralLabel" : "Spheres" } }, "properties" : { "count" : { "valueType" : "number" }, "date" : { "valueType" : "date" }, "changeDate" : { "valueType" : "date" }, "url" : { "valueType" : "url" }, "id" : { "valueType" : "url" }, "tags" : { "valueType" : "item" }, "user" : { "valueType" : "item" } }, "items" : [ { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2e278e56571667204e41214ae82b33ff8/inspo5", "tags" : [ "Age","Gastrocnemius","Mechanical","Morphology","Muscle","Oryctolagus","Plantaris","Soleus","characteristics","cuniculus","dependent","experiments","microstructure","muscle","muscles","tissue" ], "intraHash" : "e278e56571667204e41214ae82b33ff8", "interHash" : "69776921c88e79d221d10d5313558951", "label" : "Age-dependent properties of the rabbit calf musculature \u2014 Relationship between mechanic and microstructure", "user" : "inspo5", "description" : "", "date" : "2025-05-15 15:36:41", "changeDate" : "2025-05-15 15:36:41", "count" : 2, "pub-type": "article", "journal": "Journal of the Mechanical Behavior of Biomedical Materials","publisher":"Elsevier BV", "year": "2025", "url": "http://dx.doi.org/10.1016/j.jmbbm.2025.107008", "author": [ "Markus Böl","Kay Leichsenring","Steven Kutschke","Fabian Walter","Tobias Siebert" ], "authors": [ {"first" : "Markus", "last" : "Böl"}, {"first" : "Kay", "last" : "Leichsenring"}, {"first" : "Steven", "last" : "Kutschke"}, {"first" : "Fabian", "last" : "Walter"}, {"first" : "Tobias", "last" : "Siebert"} ], "editor": [ "Tobias Siebert" ], "editors": [ {"first" : "Tobias", "last" : "Siebert"} ], "volume": "168","pages": "107008","abstract": "In order to meet the requirements of body weight and height and the associated changing tasks and movement patterns during the growth of living bodies, significant changes in the skeletal musculature occur during this phase. In this study, the age-dependent (between 21 and 100 days) mechanical and microstructural tissue behaviour of the calf musculature, consisting of soleus muscles (SOL), gastrocnemius muscles (GAS) and plantaris muscles (PLA), was examined. To this end, cubic muscle tissue samples were examined using axial and semi-confined compression experiments. In addition, the essential muscle tissue components (muscle fibres, extracellular matrix, remaining components) were analysed. In a final step, these results were linked to morphological properties of the animals and muscles (animal mass, muscle mass, tibia length). Interestingly, the mechanical properties of the individual muscle types hardly differ from each other during growth, while both the morphological and microstructural properties change significantly. Thus, a clear increase of all morphological parameters (animal mass by 850%, muscle mass by 1000% (SOL), 1183% (GAS) and 1050% (PLA), tibia length by 235%) can be seen. In comparison, the microstructural parameters show a less consistent trend. The proportion of muscle fibres in the tissue cross-section increases by about 138% in the SOL, whereas the fibre proportion in both the GAS and PLA increases by only 109%. Consequently, the ECM proportion in the tissue cross-section decreases by 48%, 58% and 52% for SOL, GAS and PLA. Overall, the data obtained her e provides a deeper understanding of muscle growth and, in particular, of different muscle types that have different functions inside the calf. On the other hand, these data represent a good and comprehensive basis for later model developments.", "language" : "English", "issn" : "1751-6161", "doi" : "10.1016/j.jmbbm.2025.107008", "bibtexKey": "B_l_2025" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/20e9dbe076502380e2b8e70a80da95818/inspo5", "tags" : [ "Age-dependent","Axial","Inspo","Microstructural","Morphometry","Oryctolagus","Semi-confined","Siebert","Soleus","characteristics","compression","cuniculus","muscle","properties","tests","tissue" ], "intraHash" : "0e9dbe076502380e2b8e70a80da95818", "interHash" : "6afbb85807dbc73f3599b68ac7ec0018", "label" : "Age-dependent mechanical and microstructural properties of the rabbit soleus muscle", "user" : "inspo5", "description" : "", "date" : "2022-07-19 11:10:29", "changeDate" : "2022-07-19 09:10:56", "count" : 1, "pub-type": "article", "journal": "Acta Biomaterialia","publisher":"Elsevier BV", "year": "2021", "url": "https://doi.org/10.1016%2Fj.actbio.2021.07.066", "author": [ "Kay Leichsenring","Asha Viswanathan","Steven Kutschke","Markus Siebert, TobiasBöl" ], "authors": [ {"first" : "Kay", "last" : "Leichsenring"}, {"first" : "Asha", "last" : "Viswanathan"}, {"first" : "Steven", "last" : "Kutschke"}, {"first" : "Markus", "last" : "Siebert, TobiasBöl"} ], "editor": [ "Tobias Siebert" ], "editors": [ {"first" : "Tobias", "last" : "Siebert"} ], "volume": "134","pages": "453--465","abstract": "During growth there are serious changes in the skeletal muscles to compensate for the changed requirements in terms of body weight and size. In this study, the age-dependent (between 21 and 100 days) mechanical and microstructural properties of rabbit soleus muscle tissue were investigated. For this purpose, morphological properties (animal mass, soleus muscle mass, tibial length) were measured at 5 different times during aging. On the other hand, fibre orientation-dependent axial and semi-confined compression experiments were realised. In addition, the essential components (muscle fibres, extracellular matrix, remaining components), dominating the microstructure of muscle tissue, were analysed. While the mechanical results show hardly any age-dependent differences, the morphological and microstructural results show clear age-dependent differences. All morphological parameters increase significantly (animal mass by 839.2%, muscle mass 1050.6%, tibial length 233.6%). In contrast, microstructural parameters change differently. The percentage of fibres (divided into slow-twitch (ST) and fast-twitch (FT) fibres) increases significantly (137.6%), while the proportions of the extracellular matrix and the remaining components (48.2% and 46.1%) decrease. At the same time, the cross-sectional area of the fibres increases significantly (697.9%). The totality of this age-dependent information provides a deeper understanding of age-related changes in muscle structure and function and may contribute to successful development and validation of growth models in the future.\n\nStatement of significance\nThis article reports the first comprehensive data set on age-dependent morphological (animal mass, soleus muscle mass, tibial length), mechanical (axial and semi-confined compression), and microstructural (muscle fibres, extracellular matrix, remaining components) properties of the rabbit soleus muscle. On the one hand, the results of this study contribute to the understanding of muscle mechanics and thus to understanding of load transfer mechanisms inside the muscle tissue during growth. On the other hand, these results are relevant to the fields of constitutive formulation of age-dependent muscle tissue.", "doi" : "10.1016/j.actbio.2021.07.066", "bibtexKey": "Leichsenring_2021" } ] }