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         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/2a8704533a8dfa10f1d5f42ed6d4aef19/slegewie",         
         "tags" : [
            "Animals,","Base","Development,","Drosophila","Embryonic","Expression","Gene","Genetic,","Glucose,","Kinetics,","Messenger,","Proteins,","Proteome,","RNA,","Regulation,","Sequence,","Transcription,","Transcriptome","melanogaster,"
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         "label" : "Quantifying post-transcriptional regulation in the development of Drosophila melanogaster",
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         "date" : "2025-03-05 15:52:38",
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         "pub-type": "article",
         "journal": "Nature Communications",
         "year": "2018", 
         "url": "", 
         
         "author": [ 
            "Kolja Becker","Alina Bluhm","Nuria Casas-Vila","Nadja Dinges","Mario Dejung","Sergi Sayols","Clemens Kreutz","Jean-Yves Roignant","Falk Butter","Stefan Legewie"
         ],
         "authors": [
         	
            	{"first" : "Kolja",	"last" : "Becker"},
            	{"first" : "Alina",	"last" : "Bluhm"},
            	{"first" : "Nuria",	"last" : "Casas-Vila"},
            	{"first" : "Nadja",	"last" : "Dinges"},
            	{"first" : "Mario",	"last" : "Dejung"},
            	{"first" : "Sergi",	"last" : "Sayols"},
            	{"first" : "Clemens",	"last" : "Kreutz"},
            	{"first" : "Jean-Yves",	"last" : "Roignant"},
            	{"first" : "Falk",	"last" : "Butter"},
            	{"first" : "Stefan",	"last" : "Legewie"}
         ],
         "volume": "9","number": "1","pages": "4970","abstract": "Even though proteins are produced from mRNA, the correlation between mRNA levels and protein abundances is moderate in most studies, occasionally attributed to complex post-transcriptional regulation. To address this, we generate a paired transcriptome/proteome time course dataset with 14 time points during Drosophila embryogenesis. Despite a limited mRNA-protein correlation (ρ\u2009=\u20090.54), mathematical models describing protein translation and degradation explain 84\\% of protein time-courses based on the measured mRNA dynamics without assuming complex post transcriptional regulation, and allow for classification of most proteins into four distinct regulatory scenarios. By performing an in-depth characterization of the putatively post-transcriptionally regulated genes, we postulate that the RNA-binding protein Hrb98DE is involved in post-transcriptional control of sugar metabolism in early embryogenesis and partially validate this hypothesis using Hrb98DE knockdown. In summary, we present a systems biology framework for the identification of post-transcriptional gene regulation from large-scale, time-resolved transcriptome and proteome data.",
         "language" : "eng",
         
         "pmid" : "30478415",
         
         "file" : "Volltext:C\\:\\\\Users\\\\SL\\\\Zotero\\\\storage\\\\U4MU6BPV\\\\Becker et al. - 2018 - Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.pdf:application/pdf",
         
         "issn" : "2041-1723",
         
         "pmcid" : "PMC6255845",
         
         "doi" : "10.1038/s41467-018-07455-9",
         
         "bibtexKey": "becker_quantifying_2018"

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