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         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/2de7a507d2dfa860c2f4671cf58fdfdd3/annettegugel",         
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         "pages": "62-67",
         "eventtitle" : "VDE High Voltage Technology 2024",
         
         "venue" : "Berlin, Germany",
         
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         "eventtitle" : "2024 IEEE PES Innovative Smart Grid Technologies Europe (ISGT Europe)",
         
         "venue" : "Dubrovnik, Croatia",
         
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         "label" : "Analysis and agent-based modelling of lifestyle aspects influencing the residential energy demand in France and Germany",
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         "author": [ 
            "Wolfgang Hauser"
         ],
         "authors": [
         	
            	{"first" : "Wolfgang",	"last" : "Hauser"}
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         "language" : "en",
         
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         "author": [ 
            "Christoph Zechmeister","Marta Gil Pérez","Jan Knippers","Achim Menges"
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         "authors": [
         	
            	{"first" : "Christoph",	"last" : "Zechmeister"},
            	{"first" : "Marta",	"last" : "Gil Pérez"},
            	{"first" : "Jan",	"last" : "Knippers"},
            	{"first" : "Achim",	"last" : "Menges"}
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         "volume": "151","pages": "104889","abstract": "Coreless filament winding extends established industrial processes, enabling the fabrication of building parts with minimal formwork. Since the part's final geometry is unknown until completed, it creates uncertainties for design and engineering. Existing architectural design workflows are insufficient, and industrial software packages cannot capture the complexity of self-deforming fibres to model complex fibre layups. This research introduces a feedback-based computational method conceived as four development cycles to design and evaluate fibre layups of large-scale architectural building components, and a multi-scalar digital-physical design and evaluation toolset to model and evaluate them at multiple resolutions. The universal applicability of the developed methods is showcased by two different architectural fibre structures. The results show how the systematization of methods and toolset allow for increased design flexibility and deeper integration of interdisciplinary collaborators. They constitute an important step towards a consolidated co-design methodology and demonstrate the potential to simultaneously co-evolve design and evaluation methods.",
         "language" : "eng",
         
         "issn" : "0926-5805",
         
         "doi" : "https://doi.org/10.1016/j.autcon.2023.104889",
         
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         "label" : "Well-posedness of a quasilinear evolution problem modelling MEMS with general permittivity",
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         "author": [ 
            "Christina Lienstromberg"
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            	{"first" : "Christina",	"last" : "Lienstromberg"}
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         "volume": "17","number": "4","pages": "1129--1150","abstract": "\"Subject of consideration is the analytical investigation of a coupled system of partial differential equations arising from the modelling of electrostatically actuated microelectromechanical systems with general permittivity profile. A quasilinear parabolic evolution problem for the displacement u of an elastic membrane is coupled with an elliptic free boundary value problem that determines the electrostatic potential ψ in the region between the elastic membrane and a rigid ground plate. The system is shown to be well-posed locally in time for all arbitrarily large values λ of the applied voltage, whereas small values of the applied voltage, which do not exceed a certain critical value λ∗, do even allow globally in time existing solutions. In addition, conditions are specified which force solutions emerging from a non-positive initial deflection to stay non-positive as long as they exist.''",
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            	{"first" : "Christina",	"last" : "Lienstromberg"}
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         "author": [ 
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         "year": "2017", 
         "url": "https://doi.org/10.3934/dcdss.2017038", 
         
         "author": [ 
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            	{"first" : "Joachim",	"last" : "Escher"},
            	{"first" : "Christina",	"last" : "Lienstromberg"}
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         "volume": "10","number": "4","pages": "745--771","abstract": "\"In this survey we review some recent results on microelectromechanical systems with general permittivity profile. Different systems of differential equations are derived by taking various physical modelling aspects into account, according to the particular application. In any case an either semi- or quasilinear hyperbolic or parabolic evolution problem for the displacement of an elastic membrane is coupled with an elliptic moving boundary problem that determines the electrostatic potential in the region occupied by the elastic membrane and a rigid ground plate. Of particular interest in all models is the influence of different classes of permittivity profiles. \r\n   \"The subsequent analytical investigations are restricted to a dissipation dominated regime for the membrane's displacement. For the resulting parabolic evolution problems local well-posedness, global existence, the occurrence of finite-time singularities, and convergence of solutions to those of the so-called small-aspect ratio model, respectively, are investigated. Furthermore, a topic is addressed that is of note not till non-constant permittivity profiles are taken into account\u2014the direction of the membrane's deflection or, in mathematical parlance, the sign of the solution to the evolution problem. The survey is completed by a presentation of some numerical results that in particular justify the consideration of the coupled problem by revealing substantial qualitative differences of the solutions to the widely-used small-aspect ratio model and the coupled problem.''",
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         "changeDate" : "2022-07-19 09:10:56",
         "count" : 2,
         "pub-type": "article",
         "journal": "Acta Biomaterialia","publisher":"Elsevier BV",
         "year": "2020", 
         "url": "https://doi.org/10.1016%2Fj.actbio.2020.04.007", 
         
         "author": [ 
            "Lisa Klemm","Robert Seydewitz","Mischa Borsdorf","Tobias Siebert","Markus Böl"
         ],
         "authors": [
         	
            	{"first" : "Lisa",	"last" : "Klemm"},
            	{"first" : "Robert",	"last" : "Seydewitz"},
            	{"first" : "Mischa",	"last" : "Borsdorf"},
            	{"first" : "Tobias",	"last" : "Siebert"},
            	{"first" : "Markus",	"last" : "Böl"}
         ],
         
         "editor": [ 
            "Tobias Siebert"
         ],
         "editors": [
         	
            	{"first" : "Tobias",	"last" : "Siebert"}
         ],
         "volume": "109","pages": "163--181",
         "doi" : "10.1016/j.actbio.2020.04.007",
         
         "bibtexKey": "Klemm_2020"

      }
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         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/286d35e263b284d088ad36a772e8c40b6/inspo5",         
         "tags" : [
            "Active","Ex","Inspo","Siebert","Urinary","Whole","bladder","characteristics","experiments","modelling","organ","vivo"
         ],
         
         "intraHash" : "86d35e263b284d088ad36a772e8c40b6",
         "interHash" : "032878f78a28d5cf534daf6847ed894d",
         "label" : "A pilot study on active and passive ex vivo characterisation of the urinary bladder and its impact on three-dimensional modelling",
         "user" : "inspo5",
         "description" : "",
         "date" : "2022-07-19 11:10:29",
         "changeDate" : "2022-07-19 09:10:56",
         "count" : 2,
         "pub-type": "article",
         "journal": "Journal of the Mechanical Behavior of Biomedical Materials","publisher":"Elsevier BV",
         "year": "2022", 
         "url": "https://doi.org/10.1016%2Fj.jmbbm.2022.105347", 
         
         "author": [ 
            "Robin Trostorf","Enrique Morales Orcajo","Amelie Pötzke","Tobias Siebert","Markus Böl"
         ],
         "authors": [
         	
            	{"first" : "Robin",	"last" : "Trostorf"},
            	{"first" : "Enrique Morales",	"last" : "Orcajo"},
            	{"first" : "Amelie",	"last" : "Pötzke"},
            	{"first" : "Tobias",	"last" : "Siebert"},
            	{"first" : "Markus",	"last" : "Böl"}
         ],
         
         "editor": [ 
            "Tobias Siebert"
         ],
         "editors": [
         	
            	{"first" : "Tobias",	"last" : "Siebert"}
         ],
         "volume": "133","pages": "105347","abstract": "Insight into the global deformation of the urinary bladder during passive and active phases is crucial for understanding the biomechanics and function of the organ. Therefore, in the present study, the three-dimensional deformations of the porcine urinary bladder were investigated using 10 cameras in ex vivo experiments. Voltages between 20 V and 40 V were applied to induce contraction without outflow (isovolumetric) and against different back pressures (isobaric). The fluid volume in the bladder and the fluid volume pushed out of the bladder in the active state were measured. During filling, a roughly constant pressure of 2.5\u20134 cmH2O was measured for a large volume range, followed by a steep increase. Overall, the urinary bladder shape changes from elliptical to spherical in the active phase, resulting in a more homogeneous stress field. The active pressure decreases with increasing volume, while the actively generated stress increases up to 65 kPa at the maximum volume examined. Smaller filling volumes and lower back pressures allowed complete emptying, whereas higher back pressures prevent full emptying from larger filling states. Finally, a recently developed three-dimensional model was used to describe the active and passive bladder characteristics in order to qualitatively represent the mechanical properties. Overall, this study provides for the first time a comprehensive experimental data set at organ level that leads to an improved understanding of load transfer mechanisms within the urinary bladder and serves to validate corresponding models.",
         "doi" : "10.1016/j.jmbbm.2022.105347",
         
         "bibtexKey": "Trostorf_2022"

      }
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      {
         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/24b191d99e897e26df3f0f2cddb6083de/annettegugel",         
         "tags" : [
            "Distribution","Electric","Era","Load","Mobility.","Modelling","Planning","and","in","of","the"
         ],
         
         "intraHash" : "4b191d99e897e26df3f0f2cddb6083de",
         "interHash" : "4d116c82246d88beab7f97ce024f0fc8",
         "label" : "Load Modelling and Distribution Planning in the Era of Electric Mobility.",
         "user" : "annettegugel",
         "description" : "",
         "date" : "2022-02-14 13:26:04",
         "changeDate" : "2022-02-14 12:26:04",
         "count" : 1,
         "pub-type": "article",
         "journal": "CIRED Technical Report 2018-1",
         "year": "2021", 
         "url": "", 
         
         "author": [ 
            "Kathrin Walz","Krzysztof Rudion","al. et"
         ],
         "authors": [
         	
            	{"first" : "Kathrin",	"last" : "Walz"},
            	{"first" : "Krzysztof",	"last" : "Rudion"},
            	{"first" : "al.",	"last" : "et"}
         ],
         
         "bibtexKey": "walz2021modelling"

      }
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      {
         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/265b4f9dff8c66a01a285133f33d8b844/petraheim",         
         "tags" : [
            "2021","agent-based","amtsberg","architecture","bechert","composite","computational","density","design","itke","knippers","krtschil","menges","methods","modelling","multi-directional","multi-storey","orozco","skoury","slab","systems","timber","variable","wagner"
         ],
         
         "intraHash" : "65b4f9dff8c66a01a285133f33d8b844",
         "interHash" : "442ccbf50a181614bb7f5979b3441de5",
         "label" : "Design Methods for Variable Density, Multi-Directional Composite Timber Slab Systems for Multi-Storey",
         "user" : "petraheim",
         "description" : "",
         "date" : "2022-01-27 15:32:10",
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         "pub-type": "inproceedings",
         "booktitle": "Proceedings of the 39th eCAADe Conference","publisher":"Cumincad","address":"Novi Sad",
         "year": "2021", 
         "url": "http://papers.cumincad.org/cgi-bin/works/paper/ecaade2021_284", 
         
         "author": [ 
            "Luis Orozco","Anna Krtschil","Hans Jakob Wagner","Simon Bechert","Felix Amtsberg","Lior Skoury","Jan Knippers","Achim Menges"
         ],
         "authors": [
         	
            	{"first" : "Luis",	"last" : "Orozco"},
            	{"first" : "Anna",	"last" : "Krtschil"},
            	{"first" : "Hans Jakob",	"last" : "Wagner"},
            	{"first" : "Simon",	"last" : "Bechert"},
            	{"first" : "Felix",	"last" : "Amtsberg"},
            	{"first" : "Lior",	"last" : "Skoury"},
            	{"first" : "Jan",	"last" : "Knippers"},
            	{"first" : "Achim",	"last" : "Menges"}
         ],
         
         "editor": [ 
            "V Stojakovic","B Tepavcevic"
         ],
         "editors": [
         	
            	{"first" : "V",	"last" : "Stojakovic"},
            	{"first" : "B",	"last" : "Tepavcevic"}
         ],
         "volume": "1","pages": "303--312","abstract": "This paper presents an agent-based method for the design of complex timber structures. This method features a multi-level agent simulation, that relies on a feedback loop between agent systems and structural simulations that update the agent environment. Such an approach can usefully be applied for the design of variable density timber slab systems, where material arrangements based on structural, fabrication, and architectural boundary conditions are necessary. Such arrangements can lead to multi-directional spanning slabs that can accept pointwise supports in unique layouts. We discuss the implementation of such a method on the basis of the structural design of a pavilion-scale multi-storey testing setup. The presented method enables a more versatile approach to the design of multi-storey timber buildings, which should increase their applicability to a diverse range of building typologies.",
         "language" : "eng",
         
         "file" : ":C\\:/Users/ac128044/Google Drive/ICD_Wagner/01_Publikationen/PUBLICATION_COLLECTION/2021_ECAADE_METHODS_SLAB_DESIGN.pdf:pdf",
         
         "bibtexKey": "Orozco2021"

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         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/265b4f9dff8c66a01a285133f33d8b844/itke",         
         "tags" : [
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         "interHash" : "442ccbf50a181614bb7f5979b3441de5",
         "label" : "Design Methods for Variable Density, Multi-Directional Composite Timber Slab Systems for Multi-Storey",
         "user" : "itke",
         "description" : "",
         "date" : "2022-01-27 15:32:10",
         "changeDate" : "2022-01-27 14:32:10",
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         "pub-type": "inproceedings",
         "booktitle": "Proceedings of the 39th eCAADe Conference","publisher":"Cumincad","address":"Novi Sad",
         "year": "2021", 
         "url": "http://papers.cumincad.org/cgi-bin/works/paper/ecaade2021_284", 
         
         "author": [ 
            "Luis Orozco","Anna Krtschil","Hans Jakob Wagner","Simon Bechert","Felix Amtsberg","Lior Skoury","Jan Knippers","Achim Menges"
         ],
         "authors": [
         	
            	{"first" : "Luis",	"last" : "Orozco"},
            	{"first" : "Anna",	"last" : "Krtschil"},
            	{"first" : "Hans Jakob",	"last" : "Wagner"},
            	{"first" : "Simon",	"last" : "Bechert"},
            	{"first" : "Felix",	"last" : "Amtsberg"},
            	{"first" : "Lior",	"last" : "Skoury"},
            	{"first" : "Jan",	"last" : "Knippers"},
            	{"first" : "Achim",	"last" : "Menges"}
         ],
         
         "editor": [ 
            "V Stojakovic","B Tepavcevic"
         ],
         "editors": [
         	
            	{"first" : "V",	"last" : "Stojakovic"},
            	{"first" : "B",	"last" : "Tepavcevic"}
         ],
         "volume": "1","pages": "303--312","abstract": "This paper presents an agent-based method for the design of complex timber structures. This method features a multi-level agent simulation, that relies on a feedback loop between agent systems and structural simulations that update the agent environment. Such an approach can usefully be applied for the design of variable density timber slab systems, where material arrangements based on structural, fabrication, and architectural boundary conditions are necessary. Such arrangements can lead to multi-directional spanning slabs that can accept pointwise supports in unique layouts. We discuss the implementation of such a method on the basis of the structural design of a pavilion-scale multi-storey testing setup. The presented method enables a more versatile approach to the design of multi-storey timber buildings, which should increase their applicability to a diverse range of building typologies.",
         "language" : "eng",
         
         "file" : ":C\\:/Users/ac128044/Google Drive/ICD_Wagner/01_Publikationen/PUBLICATION_COLLECTION/2021_ECAADE_METHODS_SLAB_DESIGN.pdf:pdf",
         
         "bibtexKey": "Orozco2021"

      }
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      {
         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/262d8655ed9fcaf40d3d97288715e65f8/mariusoei1",         
         "tags" : [
            "adaptivity","fluid","foldcore","modelling"
         ],
         
         "intraHash" : "62d8655ed9fcaf40d3d97288715e65f8",
         "interHash" : "ea3ac417bcff76ad72d142d8fa0dbb43",
         "label" : "Modelling the Flow and Heat Transfer Characteristics of Perforated Foldcore Sandwich Composites for Application in Room Air Conditioning",
         "user" : "mariusoei1",
         "description" : "",
         "date" : "2021-12-09 16:54:50",
         "changeDate" : "2021-12-09 15:54:50",
         "count" : 8,
         "pub-type": "inproceedings",
         "booktitle": "IEEE 15th International Conference on Automation Science and Engineering (CASE)","publisher":"IEEE","address":"Piscataway, New Jersey",
         "year": "2019", 
         "url": "", 
         
         "author": [ 
            "Marius Oei","Yves Klett","Nadine Harder","Daniela Flemming","Oliver Sawodny"
         ],
         "authors": [
         	
            	{"first" : "Marius",	"last" : "Oei"},
            	{"first" : "Yves",	"last" : "Klett"},
            	{"first" : "Nadine",	"last" : "Harder"},
            	{"first" : "Daniela",	"last" : "Flemming"},
            	{"first" : "Oliver",	"last" : "Sawodny"}
         ],
         "pages": "1269--1274",
         "isbn" : "978-1-7281-0356-3",
         
         "file" : "Oei, Klett et al 2019 - Modelling the Flow and Heat:Attachments/Oei, Klett et al 2019 - Modelling the Flow and Heat.pdf:application/pdf",
         
         "doi" : "10.1109/COASE.2019.8842913",
         
         "bibtexKey": "Oei2019"

      }
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         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/2fdb26ab5338ccadb8291a5653e0f49af/istbib",         
         "tags" : [
            "rodent","myown","liver","multi-scale","mechanoperception","modelling","from:sebastianhpfl","liver-regeneration","surgery"
         ],
         
         "intraHash" : "fdb26ab5338ccadb8291a5653e0f49af",
         "interHash" : "389894aa4dbf59e267e06af03808a93d",
         "label" : "Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function",
         "user" : "istbib",
         "description" : "",
         "date" : "2021-11-18 12:20:38",
         "changeDate" : "2021-11-18 11:20:38",
         "count" : 3,
         "pub-type": "article",
         "journal": "Frontiers in Physiology",
         "year": "2021", 
         "url": "http://links.email.frontiersin.org/ls/click?upn=Dpg5ochww630xh6EMvshS4k2vZe-2Fd8MH-2FVpzt1-2FUQD91C-2FNL5bIclwWnNjv5HD9idQ2ALExiB7d-2BHfTn8nkJmPB-2F087l0isTMxEVZu3OzPlD1aKS25KwEYbWhaG8cFuMAQtXji0g7-2FH59a1fvyOGGVyHZ7bBAn-2BAnVl5mKfhKg70RlGhDYedxom-2BHEipZXG8fGE7zCJlmV2XJkMyN6IJj27ohquG0KYG1P8PXC6HWhlToyz0SQ1TI8SjGFM4nN1I5r70pcvrk1UzGO3zJNiXfv5jzG-2FNQdPMgjgCOZscq3UQOcRz-2F02mOUBVTPWbYXmXAb-U_cQh34FYGu-2BDHV4jJ0uA0gceKwiJf0xx6Z8ampPwKegM71b-2BfYAkWv3ghZG-2Fuak5SOgSi4bODiPlcWSvntoqSSrH6oGPS1xu1NoxKjY3IS0DccNNUQiRWF27tb28AaxdyPyQd4vEu7WaiZZUm3z7k3UFLvdzYlY-2B7pFQpmXt9zueiozsrPxSqCY-2F6Qv2Tdo0nzRI4x9TbQXhEVII3n8AdMAEcFX-2FFbk7dn-2BgfG-2FmJRrGsGqnRTeGre-2Bc2Gpeq1O15HUbM9Sh013VDjkxYla7hFw-3D-3D", 
         
         "author": [ 
            "Bruno Christ","Maximilian Collatz","Uta Dahmen","Karl-Heinz Herrmann","Sebastian Höpfl","Matthias König","Lena Lambers","Manja Marz","Daria Meyer","Nicole Radde","Jürgen R. Reichenbach","Tim Ricken","Hans-Michael Tautenhahn"
         ],
         "authors": [
         	
            	{"first" : "Bruno",	"last" : "Christ"},
            	{"first" : "Maximilian",	"last" : "Collatz"},
            	{"first" : "Uta",	"last" : "Dahmen"},
            	{"first" : "Karl-Heinz",	"last" : "Herrmann"},
            	{"first" : "Sebastian",	"last" : "Höpfl"},
            	{"first" : "Matthias",	"last" : "König"},
            	{"first" : "Lena",	"last" : "Lambers"},
            	{"first" : "Manja",	"last" : "Marz"},
            	{"first" : "Daria",	"last" : "Meyer"},
            	{"first" : "Nicole",	"last" : "Radde"},
            	{"first" : "Jürgen R.",	"last" : "Reichenbach"},
            	{"first" : "Tim",	"last" : "Ricken"},
            	{"first" : "Hans-Michael",	"last" : "Tautenhahn"}
         ],
         "volume": "12","abstract": "Liver resection causes marked perfusion alterations in the liver remnant both on the organ scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level). These changes in perfusion affect hepatic functions via direct alterations in blood supply and drainage, followed by indirect changes of biomechanical tissue properties and cellular function. Changes in blood flow impose compression, tension and shear forces on the liver tissue. These forces are perceived by mechanosensors on parenchymal and non-parenchymal cells of the liver and regulate cell-cell and cell-matrix interactions as well as cellular signaling and metabolism. These interactions are key players in tissue growth and remodeling, a prerequisite to restore tissue function after PHx. Their dysregulation is associated with metabolic impairment of the liver eventually leading to liver failure, a serious post-hepatectomy complication with high morbidity and mortality. Though certain links are known, the overall functional change after liver surgery is not understood due to complex feedback loops, non-linearities, spatial heterogeneities and different time-scales of events. Computational modeling is a unique approach to gain a better understanding of complex biomedical systems. This approach allows (i) integration of heterogeneous data and knowledge on multiple scales into a consistent view of how perfusion is related to hepatic function; (ii) testing and generating hypotheses based on predictive models, which must be validated experimentally and clinically. In the long term, computational modeling will (iii) support surgical planning by predicting surgery-induced perfusion perturbations and their functional (metabolic) consequences; and thereby (iv) allow minimizing surgical risks for the individual patient. Here, we review the alterations of hepatic perfusion, biomechanical properties and function associated with hepatectomy. Specifically, we provide an overview over the clinical problem, preoperative diagnostics, functional imaging approaches, experimental approaches in animal models, mechanoperception in the liver and impact on cellular metabolism, omics approaches with a focus on transcriptomics, data integration and uncertainty analysis, and computational modeling on multiple scales. Finally, we provide a perspective on how multi-scale computational models, which couple perfusion changes to hepatic function, could become part of clinical workflows to predict and optimize patient outcome after complex liver surgery.",
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         "doi" : "10.3389/fphys.2021.733868",
         
         "bibtexKey": "Christ.2021"

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         "journal": "Frontiers in Physiology",
         "year": "2021", 
         "url": "http://links.email.frontiersin.org/ls/click?upn=Dpg5ochww630xh6EMvshS4k2vZe-2Fd8MH-2FVpzt1-2FUQD91C-2FNL5bIclwWnNjv5HD9idQ2ALExiB7d-2BHfTn8nkJmPB-2F087l0isTMxEVZu3OzPlD1aKS25KwEYbWhaG8cFuMAQtXji0g7-2FH59a1fvyOGGVyHZ7bBAn-2BAnVl5mKfhKg70RlGhDYedxom-2BHEipZXG8fGE7zCJlmV2XJkMyN6IJj27ohquG0KYG1P8PXC6HWhlToyz0SQ1TI8SjGFM4nN1I5r70pcvrk1UzGO3zJNiXfv5jzG-2FNQdPMgjgCOZscq3UQOcRz-2F02mOUBVTPWbYXmXAb-U_cQh34FYGu-2BDHV4jJ0uA0gceKwiJf0xx6Z8ampPwKegM71b-2BfYAkWv3ghZG-2Fuak5SOgSi4bODiPlcWSvntoqSSrH6oGPS1xu1NoxKjY3IS0DccNNUQiRWF27tb28AaxdyPyQd4vEu7WaiZZUm3z7k3UFLvdzYlY-2B7pFQpmXt9zueiozsrPxSqCY-2F6Qv2Tdo0nzRI4x9TbQXhEVII3n8AdMAEcFX-2FFbk7dn-2BgfG-2FmJRrGsGqnRTeGre-2Bc2Gpeq1O15HUbM9Sh013VDjkxYla7hFw-3D-3D", 
         
         "author": [ 
            "Bruno Christ","Maximilian Collatz","Uta Dahmen","Karl-Heinz Herrmann","Sebastian Höpfl","Matthias König","Lena Lambers","Manja Marz","Daria Meyer","Nicole Radde","Jürgen R. Reichenbach","Tim Ricken","Hans-Michael Tautenhahn"
         ],
         "authors": [
         	
            	{"first" : "Bruno",	"last" : "Christ"},
            	{"first" : "Maximilian",	"last" : "Collatz"},
            	{"first" : "Uta",	"last" : "Dahmen"},
            	{"first" : "Karl-Heinz",	"last" : "Herrmann"},
            	{"first" : "Sebastian",	"last" : "Höpfl"},
            	{"first" : "Matthias",	"last" : "König"},
            	{"first" : "Lena",	"last" : "Lambers"},
            	{"first" : "Manja",	"last" : "Marz"},
            	{"first" : "Daria",	"last" : "Meyer"},
            	{"first" : "Nicole",	"last" : "Radde"},
            	{"first" : "Jürgen R.",	"last" : "Reichenbach"},
            	{"first" : "Tim",	"last" : "Ricken"},
            	{"first" : "Hans-Michael",	"last" : "Tautenhahn"}
         ],
         "volume": "12","abstract": "Liver resection causes marked perfusion alterations in the liver remnant both on the organ scale (vascular anatomy) and on the microscale (sinusoidal blood flow on tissue level). These changes in perfusion affect hepatic functions via direct alterations in blood supply and drainage, followed by indirect changes of biomechanical tissue properties and cellular function. Changes in blood flow impose compression, tension and shear forces on the liver tissue. These forces are perceived by mechanosensors on parenchymal and non-parenchymal cells of the liver and regulate cell-cell and cell-matrix interactions as well as cellular signaling and metabolism. These interactions are key players in tissue growth and remodeling, a prerequisite to restore tissue function after PHx. Their dysregulation is associated with metabolic impairment of the liver eventually leading to liver failure, a serious post-hepatectomy complication with high morbidity and mortality. Though certain links are known, the overall functional change after liver surgery is not understood due to complex feedback loops, non-linearities, spatial heterogeneities and different time-scales of events. Computational modeling is a unique approach to gain a better understanding of complex biomedical systems. This approach allows (i) integration of heterogeneous data and knowledge on multiple scales into a consistent view of how perfusion is related to hepatic function; (ii) testing and generating hypotheses based on predictive models, which must be validated experimentally and clinically. In the long term, computational modeling will (iii) support surgical planning by predicting surgery-induced perfusion perturbations and their functional (metabolic) consequences; and thereby (iv) allow minimizing surgical risks for the individual patient. Here, we review the alterations of hepatic perfusion, biomechanical properties and function associated with hepatectomy. Specifically, we provide an overview over the clinical problem, preoperative diagnostics, functional imaging approaches, experimental approaches in animal models, mechanoperception in the liver and impact on cellular metabolism, omics approaches with a focus on transcriptomics, data integration and uncertainty analysis, and computational modeling on multiple scales. Finally, we provide a perspective on how multi-scale computational models, which couple perfusion changes to hepatic function, could become part of clinical workflows to predict and optimize patient outcome after complex liver surgery.",
         "file" : "Christ\\_2021\\_Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function:Attachments/Christ\\_2021\\_Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function.pdf:application/pdf",
         
         "doi" : "10.3389/fphys.2021.733868",
         
         "bibtexKey": "ist:Christ.21a"

      }
,
      {
         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/265b4f9dff8c66a01a285133f33d8b844/intcdc",         
         "tags" : [
            "agent-based","buildings","computational","construction","design","from:hansjakobwagner","itech","modelling","multi-storey","peer","robotic","rp3","rp4","timber"
         ],
         
         "intraHash" : "65b4f9dff8c66a01a285133f33d8b844",
         "interHash" : "442ccbf50a181614bb7f5979b3441de5",
         "label" : "Design Methods for Variable Density, Multi-Directional Composite Timber Slab Systems for Multi-Storey",
         "user" : "intcdc",
         "description" : "",
         "date" : "2021-09-15 14:28:23",
         "changeDate" : "2021-09-15 13:48:41",
         "count" : 7,
         "pub-type": "inproceedings",
         "booktitle": "Proceedings of the 39th eCAADe Conference","publisher":"Cumincad","address":"Novi Sad",
         "year": "2021", 
         "url": "http://papers.cumincad.org/cgi-bin/works/paper/ecaade2021_284", 
         
         "author": [ 
            "Luis Orozco","Anna Krtschil","Hans Jakob Wagner","Simon Bechert","Felix Amtsberg","Lior Skoury","Jan Knippers","Achim Menges"
         ],
         "authors": [
         	
            	{"first" : "Luis",	"last" : "Orozco"},
            	{"first" : "Anna",	"last" : "Krtschil"},
            	{"first" : "Hans Jakob",	"last" : "Wagner"},
            	{"first" : "Simon",	"last" : "Bechert"},
            	{"first" : "Felix",	"last" : "Amtsberg"},
            	{"first" : "Lior",	"last" : "Skoury"},
            	{"first" : "Jan",	"last" : "Knippers"},
            	{"first" : "Achim",	"last" : "Menges"}
         ],
         
         "editor": [ 
            "V Stojakovic","B Tepavcevic"
         ],
         "editors": [
         	
            	{"first" : "V",	"last" : "Stojakovic"},
            	{"first" : "B",	"last" : "Tepavcevic"}
         ],
         "volume": "1","pages": "303--312","abstract": "This paper presents an agent-based method for the design of complex timber structures. This method features a multi-level agent simulation, that relies on a feedback loop between agent systems and structural simulations that update the agent environment. Such an approach can usefully be applied for the design of variable density timber slab systems, where material arrangements based on structural, fabrication, and architectural boundary conditions are necessary. Such arrangements can lead to multi-directional spanning slabs that can accept pointwise supports in unique layouts. We discuss the implementation of such a method on the basis of the structural design of a pavilion-scale multi-storey testing setup. The presented method enables a more versatile approach to the design of multi-storey timber buildings, which should increase their applicability to a diverse range of building typologies.",
         "file" : ":C\\:/Users/ac128044/Google Drive/ICD_Wagner/01_Publikationen/PUBLICATION_COLLECTION/2021_ECAADE_METHODS_SLAB_DESIGN.pdf:pdf",
         
         "bibtexKey": "Orozco2021"

      }
	  
   ]
}
