{ "types" : { "Bookmark" : { "pluralLabel" : "Bookmarks" }, "Publication" : { "pluralLabel" : "Publications" }, "GoldStandardPublication" : { "pluralLabel" : "GoldStandardPublications" }, "GoldStandardBookmark" : { "pluralLabel" : "GoldStandardBookmarks" }, "Tag" : { "pluralLabel" : "Tags" }, "User" : { "pluralLabel" : "Users" }, "Group" : { "pluralLabel" : "Groups" }, "Sphere" : { "pluralLabel" : "Spheres" } }, "properties" : { "count" : { "valueType" : "number" }, "date" : { "valueType" : "date" }, "changeDate" : { "valueType" : "date" }, "url" : { "valueType" : "url" }, "id" : { "valueType" : "url" }, "tags" : { "valueType" : "item" }, "user" : { "valueType" : "item" } }, "items" : [ { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2e9294d19b2f705461fe8340bf970a6fb/inspo5", "tags" : [ "Fiber","Lateral","length","mechanics","matrix","heterogeneity","Extracellular","transmission","Endomysial","force","Sarcomere","bundle","connections" ], "intraHash" : "e9294d19b2f705461fe8340bf970a6fb", "interHash" : "7c13ec95eb31404c7683564d78305f64", "label" : "The impact of endomysium integrity on skeletal muscle fiber bundle mechanics", "user" : "inspo5", "description" : "", "date" : "2025-11-05 15:18:13", "changeDate" : "2025-11-05 15:18:13", "count" : 2, "pub-type": "article", "journal": "Journal of Biomechanics","publisher":"Elsevier BV", "year": "2025", "url": "http://dx.doi.org/10.1016/j.jbiomech.2025.112957", "author": [ "Paolo Carlo Danesini","André Tomalka","Tobias Siebert","Filiz Ates" ], "authors": [ {"first" : "Paolo Carlo", "last" : "Danesini"}, {"first" : "André", "last" : "Tomalka"}, {"first" : "Tobias", "last" : "Siebert"}, {"first" : "Filiz", "last" : "Ates"} ], "editor": [ "Tobias Siebert" ], "editors": [ {"first" : "Tobias", "last" : "Siebert"} ], "volume": "192","pages": "112957","abstract": "The endomysium, the innermost layer of the extracellular matrix (ECM), was shown to play an important role in both passive and active force transmission. However, its mechanical contribution within muscle fiber bundles remains incompletely understood. We hypothesized that dissecting one of the endomysial connections within a fiber bundle would alter force production and lead to changes in sarcomere lengths and their heterogeneity. Muscle fiber bundles (n = 12) were extracted from the extensor digitorum longus muscles of rats and chemically skinned. Their passive and active stress-length relationships were measured under two conditions: (i) with intact endomysium and (ii) after blunt dissection of endomysial connections between two adjacent peripheral fibers. Disruption of endomysial continuity significantly reduced passive stress by 26.5 % (p < 0.01) and active stress by 21.9 % (p < 0.001) on average across all lengths tested. It also shifted the optimal fiber length (Lopt) to longer values by 6.2 % (p < 0.01). Despite these mechanical changes, average sarcomere lengths (along fibers) and their heterogeneity remained unchanged. Length heterogeneity was only observed at a longer fiber length (1.3 Lopt) in the passive state before dissection. These findings demonstrate that endomysial connections are integral to the mechanical behavior of muscle fiber bundles, influencing both passive and active stress. The absence of sarcomere length changes along fibers suggests that other microstructural mechanisms, such as altered lattice spacing or impaired lateral force transmission, may underlie the observed changes. These results highlight the importance of ECM integrity in muscle mechanics and have implications for orthopedic interventions and neuromuscular disorder management.", "issn" : "0021-9290", "doi" : "10.1016/j.jbiomech.2025.112957", "bibtexKey": "Danesini_2025" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/283fba02b010557af3f547c378cdb6de6/inspo5", "tags" : [ "fiber","Intramuscular","tissue","matrix","Extracellular","integrity","transmission","Endomysium","Connective","Muscle","force" ], "intraHash" : "83fba02b010557af3f547c378cdb6de6", "interHash" : "2d12b002242e8974ec406082ad65e8b3", "label" : "Endomysium determines active and passive force production in muscle fibers", "user" : "inspo5", "description" : "", "date" : "2024-05-08 11:25:57", "changeDate" : "2024-08-07 11:33:21", "count" : 8, "pub-type": "article", "journal": "Journal of Biomechanics","publisher":"Elsevier BV", "year": "2024", "url": "http://dx.doi.org/10.1016/j.jbiomech.2024.112134", "author": [ "Paolo Carlo Danesini","Maximilian Heim","André Tomalka","Tobias Siebert","Filiz Ates" ], "authors": [ {"first" : "Paolo", "last" : "Carlo Danesini"}, {"first" : "Maximilian", "last" : "Heim"}, {"first" : "André", "last" : "Tomalka"}, {"first" : "Tobias", "last" : "Siebert"}, {"first" : "Filiz", "last" : "Ates"} ], "editor": [ "Tobias Siebert" ], "editors": [ {"first" : "Tobias", "last" : "Siebert"} ], "volume": "168","pages": "112134","abstract": "Connective tissues can be recognized as an important structural support element in muscles. Recent studies have also highlighted its importance in active force generation and transmission between muscles, particularly through the epimysium. In the present study, we aimed to investigate the impact of the endomysium, the connective tissue surrounding muscle fibers, on both passive and active force production. Pairs of skeletal muscle fibers were extracted from the extensor digitorum longus muscles of rats and, after chemical skinning, their passive and active force\u2013length relationships were measured under two conditions: (i) with the endomysium between muscle fibers intact, and (ii) after its dissection. We found that the dissection of the endomysium caused force to significantly decrease in both active (by 22.2 % when normalized to the maximum isometric force; p < 0.001) and passive conditions (by 25.9 % when normalized to the maximum isometric force; p = 0.034). These findings indicate that the absence of endomysium compromises muscle fiber\u2019s not only passive but also active force production. This effect may be attributed to increased heterogeneity in sarcomere lengths, enhanced lattice spacing between myofilaments, or a diminished role of trans-sarcolemmal proteins due to dissecting the endomysium. Future investigations into the underlying mechanisms and their implications for various extracellular matrix-related diseases are warranted.", "language" : "English", "issn" : "0021-9290", "doi" : "10.1016/j.jbiomech.2024.112134", "bibtexKey": "Carlo_Danesini_2024" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2b9e0ef26b3072dde1659125d18d60b7c/carsten.scherer", "tags" : [ "approach","lyapunov","functions","relaxations","imng","matrix","inequality","optimization","EXC310","pn4","peerReviewed","programs","dependent" ], "intraHash" : "b9e0ef26b3072dde1659125d18d60b7c", "interHash" : "65da870d0bca9e82e2d000989caf405c", "label" : "Robust $l_1$ performance analysis for linear systems with parametric uncertainties", "user" : "carsten.scherer", "description" : "", "date" : "2021-12-07 20:40:52", "changeDate" : "2021-12-07 19:40:52", "count" : 4, "pub-type": "article", "journal": "Int. J. Control", "year": "2008", "url": "https://doi.org/10.1080/00207170701730451", "author": [ "J. M. Rieber","C. W. Scherer","F. Allgower" ], "authors": [ {"first" : "J. M.", "last" : "Rieber"}, {"first" : "C. W.", "last" : "Scherer"}, {"first" : "F.", "last" : "Allgower"} ], "volume": "81","number": "5","pages": "851-864","abstract": "In this contribution, a computational approach for analysing the robust e.-gain (or the robust l(1) performance) of uncertain linear systems is developed. In particular, the system's state-space matrices may have a rational dependence on structured parametric time-invariant or time-varying uncertainties. The computation is based on robust semi-definite programming and provides a trade-off between accuracy and computational effort. A novel matrix inequality condition to determine the star-norm of discrete-time systems is derived as an auxiliary result.", "shorttitle" : "Robust l(1) performance analysis for linear systems with parametric uncertainties", "file" : "://000255553000012", "endnotereftype" : "Journal Article", "bibtexKey": "RieSch08a" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/250eb44f91950357cf988eb9394027e14/carsten.scherer", "tags" : [ "robust","multiobjective","synthesis","control","imng","feasibility","h-infinity","inequalities","bilinear","algorithms","formulas","linear-systems","global","h-2","matrix","uncertainty","output-feedback","optimization","design","parameter","peerReviewed","lmis","structured","dynamic","order" ], "intraHash" : "50eb44f91950357cf988eb9394027e14", "interHash" : "79b43995f394ecc9dbf6ddc0aa390ca5", "label" : "Robust output-feedback controller design via local BMI optimization", "user" : "carsten.scherer", "description" : "", "date" : "2021-12-07 20:40:52", "changeDate" : "2021-12-07 19:40:52", "count" : 4, "pub-type": "article", "journal": "Automatica", "year": "2004", "url": "https://doi.org/10.1016/j.automatica.2004.01.028", "author": [ "S. Kanev","C. W. Scherer","M. Verhaegen","B. De Schutter" ], "authors": [ {"first" : "S.", "last" : "Kanev"}, {"first" : "C. W.", "last" : "Scherer"}, {"first" : "M.", "last" : "Verhaegen"}, {"first" : "B.", "last" : "De Schutter"} ], "volume": "40","number": "7","pages": "1115-1127","abstract": "The problem of designing a globally optimal full-order output-feedback controller for polytopic uncertain systems is known to be a non-convex NP-hard optimization problem, that can be represented as a bilinear matrix inequality optimization problem for most design objectives. In this paper a new approach is proposed to the design of locally optimal controllers. It is iterative by nature, and starting from any initial feasible controller it performs local optimization over a suitably defined non-convex function at each iteration. The approach features the properties of computational efficiency, guaranteed convergence to a local optimum, and applicability to a very wide range of problems. Furthermore, a fast (but conservative) LMI-based procedure for computing an initially feasible controller is also presented. The complete approach is demonstrated on a model of one joint of a real-life space robotic manipulator. (C) 2004 Elsevier Ltd. All rights reserved.", "shorttitle" : "Robust output-feedback controller design via local BMI optimization", "file" : "://000221904200002", "issn" : "0005-1098", "endnotereftype" : "Journal Article", "bibtexKey": "KanSch04a" } , { "type" : "Publication", "id" : "https://puma.ub.uni-stuttgart.de/bibtex/2b881c5bd45bba967a418431f264925f3/mhartmann", "tags" : [ "65Y20","42A82;","Interpolation;","factorization;","Matrix","Positive","15A23;","Fast","definite","computation;","vorlaeufig","41A05;","functions;" ], "intraHash" : "b881c5bd45bba967a418431f264925f3", "interHash" : "5fc476059e77e8e9226f6a15761cf6a5", "label" : "Fast computation of orthonormal basis for RBF spaces through Krylov\n\tspace methods", "user" : "mhartmann", "description" : "", "date" : "2018-07-20 10:54:15", "changeDate" : "2018-07-20 08:54:15", "count" : 4, "pub-type": "article", "journal": "BIT Numerical Mathematics","publisher":"Springer Netherlands", "year": "2015", "url": "http://dx.doi.org/10.1007/s10543-014-0537-6", "author": [ "Stefano De Marchi","Gabriele Santin" ], "authors": [ {"first" : "Stefano", "last" : "De Marchi"}, {"first" : "Gabriele", "last" : "Santin"} ], "volume": "55","number": "4","pages": "949--966","abstract": "In recent years, in the setting of radial basis function, the study\n\tof approximation algorithms has particularly focused on the construction\n\tof (stable) bases for the associated Hilbert spaces. One of the ways\n\tof describing such spaces and their properties is the study of a\n\tparticular integral operator and its spectrum. We proposed in a recent\n\twork the so-called WSVD basis, which is strictly connected to the\n\teigen-decomposition of this operator and allows to overcome some\n\tproblems related to the stability of the computation of the approximant\n\tfor a wide class of radial kernels. Although effective, this basis\n\tis computationally expensive to compute. In this paper we discuss\n\ta method to improve and compute in a fast way the basis using methods\n\trelated to Krylov subspaces. After reviewing the connections between\n\tthe two bases, we concentrate on the properties of the new one, describing\n\tits behavior by numerical tests.", "issn" : "0006-3835", "file" : ":http\\://www.mathematik.uni-stuttgart.de/fak8/ians/publications/files/DeMSa2015_www_Fast_computation_onb_RBF.pdf:PDF", "owner" : "santinge", "language" : "English", "doi" : "10.1007/s10543-014-0537-6", "bibtexKey": "demarchi2015computation" } ] }