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         "type" : "Publication",
         "id"   : "https://puma.ub.uni-stuttgart.de/bibtex/2769fc5367fc25a46ad4345656086a437/pumaizi",         
         "tags" : [
            "HFD","Senescence","izi","2025","PKD","Diabetes","hausser","β-cell","Aging"
         ],
         
         "intraHash" : "769fc5367fc25a46ad4345656086a437",
         "interHash" : "99a665bd554f04afedec797aeac08fff",
         "label" : "Protein Kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions",
         "user" : "pumaizi",
         "description" : "",
         "date" : "2025-12-15 10:13:19",
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         "pub-type": "article",
         "journal": "Molecular Metabolism",
         "year": "2025", 
         "url": "https://www.sciencedirect.com/science/article/pii/S2212877825002042", 
         
         "author": [ 
            "Wolfgang S. Lieb","Carlos O. Oueslati Morales","Kornelia Ellwanger","Claudia Koch","Sylke Lutz","Stephan A. Eisler","Annika M. Möller","Veronika Leiss","Angelika Hausser"
         ],
         "authors": [
         	
            	{"first" : "Wolfgang S.",	"last" : "Lieb"},
            	{"first" : "Carlos O.",	"last" : "Oueslati Morales"},
            	{"first" : "Kornelia",	"last" : "Ellwanger"},
            	{"first" : "Claudia",	"last" : "Koch"},
            	{"first" : "Sylke",	"last" : "Lutz"},
            	{"first" : "Stephan A.",	"last" : "Eisler"},
            	{"first" : "Annika M.",	"last" : "Möller"},
            	{"first" : "Veronika",	"last" : "Leiss"},
            	{"first" : "Angelika",	"last" : "Hausser"}
         ],
         "pages": "102297","abstract": "Insulin secretion from pancreatic β-cells is essential for maintaining glucose homeostasis and preventing type 2 diabetes, a condition closely associated with aging. Although previous studies in mice have shown that both basal and glucose-stimulated insulin secretion increase with age, the underlying mechanisms remained poorly understood. In this study, we identify protein kinase D (PKD) as a critical regulator of β-cell function during aging through its control of cellular senescence. Using β-cell\u2013specific expression of dominant-negative PKDkd-EGFP and the selective PKD inhibitor CRT0066101, we demonstrate that inhibition of PKD activity in mature adult mice induced a senescent-like β-cell phenotype characterized by enlarged cell size and elevated β-galactosidase activity. These changes were associated with decreased expression of the antioxidant enzyme superoxide dismutase 2 and increased levels of reactive oxygen species. Surprisingly, despite promoting a senescent-like phenotype, PKD inhibition significantly improved glucose tolerance, enhanced glucose-stimulated insulin secretion, and protected against high-fat diet\u2013induced glucose and insulin intolerance. These findings highlight the importance of PKD in preserving β-cell function under aging and metabolic stress conditions.",
         "issn" : "2212-8778",
         
         "doi" : "https://doi.org/10.1016/j.molmet.2025.102297",
         
         "bibtexKey": "LIEB2025102297"

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