{"c14ad8ea3d3e98ac89211f3221355de5elkepeter":{"DOI":"","ISBN":"","ISSN":"1079-9389","URL":"","abstract":"","annote":"","author":[{"family":"Wirth","given":"Jens"}],"citation-label":"MR2362265","collection-editor":[],"collection-title":"","container-author":[],"container-title":"Adv. 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Differential Equations","documents":[],"edition":"","editor":[],"event-date":{"date-parts":[["2007"]],"literal":"2007"},"event-place":"","id":"c14ad8ea3d3e98ac89211f3221355de5mathematik","interhash":"ff8c20ffd345305b144e883c60bd9a7d","intrahash":"c14ad8ea3d3e98ac89211f3221355de5","issue":"10","issued":{"date-parts":[["2007"]],"literal":"2007"},"keyword":"equations iadm scattering from:elkepeter modified wirth wave","misc":{"mrclass":"35L90 (35P25)","mrreviewer":"Jo\\~ao Pedro Boto","fjournal":"Advances in Differential Equations","mrnumber":"2362265","issn":"1079-9389"},"note":"","number":"10","number-of-pages":"18","page":"1115--1133","page-first":"1115","publisher":"","publisher-place":"","status":"","title":"Scattering and modified scattering for abstract wave equations with time-dependent dissipation.","type":"article-journal","username":"mathematik","version":"","volume":"12"},"bc1670b16ed84beabd8820d13e46b2d2bastian":{"DOI":"10.1128/AEM.01710-10","ISBN":"","ISSN":"1098-5336","URL":"","abstract":"2-Ketoisovalerate is used as a therapeutic agent, and a 2-ketoisovalerate-producing organism may serve as a platform for products deriving from this 2-keto acid. We engineered the wild type of Corynebacterium glutamicum for the growth-decoupled production of 2-ketoisovalerate from glucose by deletion of the aceE gene encoding the E1p subunit of the pyruvate dehydrogenase complex, deletion of the transaminase B gene ilvE, and additional overexpression of the ilvBNCD genes, encoding the l-valine biosynthetic enzymes acetohydroxyacid synthase (AHAS), acetohydroxyacid isomeroreductase, and dihydroxyacid dehydratase. 2-Ketoisovalerate production was further improved by deletion of the pyruvate:quinone oxidoreductase gene pqo. In fed-batch fermentations at high cell densities, the newly constructed strains produced up to 188 ± 28 mM (21.8 ± 3.2 g liter(-1)) 2-ketoisovalerate and showed a product yield of about 0.47 ± 0.05 mol per mol (0.3 ± 0.03 g per g) of glucose and a volumetric productivity of about 4.6 ± 0.6 mM (0.53 ± 0.07 g liter(-1)) 2-ketoisovalerate per h in the overall production phase. In studying the influence of the three branched-chain 2-keto acids 2-ketoisovalerate, 2-ketoisocaproate, and 2-keto-3-methylvalerate on the AHAS activity, we observed a competitive inhibition of the AHAS enzyme by 2-ketoisovalerate.","annote":"","author":[{"family":"Krause","given":"Felix S."},{"family":"Blombach","given":"Bastian"},{"family":"Eikmanns","given":"Bernhard J."}],"citation-label":"krause_metabolic_2010","collection-editor":[],"collection-title":"","container-author":[],"container-title":"Appl. Environ. Microbiol.","documents":[],"edition":"","editor":[],"event-date":{"date-parts":[["2010","dec"]],"literal":"2010"},"event-place":"","id":"bc1670b16ed84beabd8820d13e46b2d2bastian","interhash":"3154880de1726a3496ebe8869a0a7468","intrahash":"bc1670b16ed84beabd8820d13e46b2d2","issue":"24","issued":{"date-parts":[["2010","dec"]],"literal":"2010"},"keyword":"Acids, Bacterial, Corynebacterium Deletion, Engineering, Expression, Gene Genes, Genetic Genetically Glucose, Keto Metabolic Modified Networks Organisms, Pathways, and glutamicum, myown","misc":{"pmid":"20935122","issn":"1098-5336","pmcid":"PMC3008247","language":"eng","doi":"10.1128/AEM.01710-10"},"note":"","number":"24","number-of-pages":"8","page":"8053--8061","page-first":"8053","publisher":"","publisher-place":"","status":"","title":"Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production","type":"article-journal","username":"bastian","version":"","volume":"76"}}