PUMA publications for /user/bastian/Bacillus%20alcohol%20metabolichttps://puma.ub.uni-stuttgart.de/user/bastian/Bacillus%20alcohol%20metabolicPUMA RSS feed for /user/bastian/Bacillus%20alcohol%20metabolic2024-03-29T15:31:24+01:00Current knowledge on isobutanol production with Escherichia coli, Bacillus subtilis and Corynebacterium glutamicumhttps://puma.ub.uni-stuttgart.de/bibtex/20f88c2605071e1c350ed8a296eece367/bastianbastian2018-02-09T13:18:17+01:00Acids, Alcohol Bacillus Bacterial Butanols, Carboxy-Lyases, Corynebacterium Dehydrogenase, Engineering Escherichia Industrial Keto Metabolic Microbiology, Proteins, Recombinant coli, glutamicum, myown subtilis, <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Bastian Blombach" itemprop="url" href="/person/133960b6afe49761f6398812d65d1660e/author/0"><span itemprop="name">B. Blombach</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Bernhard J. Eikmanns" itemprop="url" href="/person/133960b6afe49761f6398812d65d1660e/author/1"><span itemprop="name">B. Eikmanns</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Bioeng Bugs</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">2 </span></span>(<span itemprop="issueNumber">6</span>):
<span itemprop="pagination">346--350</span></em> </span>(<em><span>December 2011<meta content="December 2011" itemprop="datePublished"/></span></em>)</span>Fri Feb 09 13:18:17 CET 2018Bioeng Bugsdec6346--350Current knowledge on isobutanol production with {Escherichia} coli, {Bacillus} subtilis and {Corynebacterium} glutamicum22011Acids, Alcohol Bacillus Bacterial Butanols, Carboxy-Lyases, Corynebacterium Dehydrogenase, Engineering Escherichia Industrial Keto Metabolic Microbiology, Proteins, Recombinant coli, glutamicum, myown subtilis, Due to steadily rising crude oil prices great efforts have been made to develop designer bugs for the fermentative production of higher alcohols, such as 2-methyl-1-butanol, 3-methyl-1-butanol and 2-Methyl-1-propanol (isobutanol), which all possess quality characteristics comparable to traditional oil based fuels. The common metabolic engineering approach uses the last two steps of the Ehrlich pathway, catalyzed by 2-ketoacid decarboxylase and an alcohol dehydrogenase converting the branched chain 2-ketoacids of L-isoleucine, L-leucine, and L-valine into the respective alcohols. This strategy was successfully used to engineer well suited and industrially employed bacteria, such as Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum for the production of higher alcohols. Among these alcohols, isobutanol is currently the most promising one regarding final titer and yield. This article summarizes the current knowledge and achievements on isobutanol production with E. coli, B. subtilis and C. glutamicum regarding the metabolic engineering approaches and process conditions.