PUMA publications for /user/cristiano/hausserhttps://puma.ub.uni-stuttgart.de/user/cristiano/hausserPUMA RSS feed for /user/cristiano/hausser2024-03-28T19:51:28+01:00Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteinshttps://puma.ub.uni-stuttgart.de/bibtex/260110e180b0abdd44d69230369bc05cd/cristianocristiano2023-06-13T09:07:59+02:002023 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Sophia Steinlein" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/0"><span itemprop="name">S. Steinlein</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Frank Essmann" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/1"><span itemprop="name">F. Essmann</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Amanda Franceschini Ghilardi" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/2"><span itemprop="name">A. Ghilardi</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Heike Horn" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/3"><span itemprop="name">H. Horn</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Julia Schüler" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/4"><span itemprop="name">J. Schüler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/5"><span itemprop="name">A. Hausser</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Lijun Sun" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/6"><span itemprop="name">L. Sun</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="German Ott" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/7"><span itemprop="name">G. Ott</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Claudia Kalla" itemprop="url" href="/person/1190d85b7f71a2227dc3c754367aa0d2a/author/8"><span itemprop="name">C. Kalla</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Frontiers in oncology</span>, </em> </span>(<em><span>May 2023<meta content="May 2023" itemprop="datePublished"/></span></em>)</span>Tue Jun 13 09:07:59 CEST 2023SwitzerlandFrontiers in oncologymay1190988--1190988Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins1320232023 hausser izi Dendritic effects of genetically encoded actin labelling probes in cultured hippocampal neuronshttps://puma.ub.uni-stuttgart.de/bibtex/20c6d7bc29bb0e3e4fd8e0f722ba0f9d1/cristianocristiano2023-03-30T08:24:13+02:002023 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Attila Ignácz" itemprop="url" href="/person/176351243ebc9ec85811ae3c280534d10/author/0"><span itemprop="name">A. Ignácz</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Domonkos Nagy-Herczeg" itemprop="url" href="/person/176351243ebc9ec85811ae3c280534d10/author/1"><span itemprop="name">D. Nagy-Herczeg</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/176351243ebc9ec85811ae3c280534d10/author/2"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Katalin Schlett" itemprop="url" href="/person/176351243ebc9ec85811ae3c280534d10/author/3"><span itemprop="name">K. Schlett</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Molecular Biology of the Cell</span>, </em> </span>(<em><span>March 2023<meta content="March 2023" itemprop="datePublished"/></span></em>)</span>Thu Mar 30 08:24:13 CEST 2023Molecular Biology of the CellmarDendritic effects of genetically encoded actin labelling probes in cultured hippocampal neurons20232023 hausser izi PKD autoinhibition in trans regulates activation loop autophosphorylation in cishttps://puma.ub.uni-stuttgart.de/bibtex/20fe2ab1f4136f10684f9dc50a867521c/cristianocristiano2023-02-07T08:59:43+01:002023 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Ronja Reinhardt" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/0"><span itemprop="name">R. Reinhardt</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Kai Hirzel" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/1"><span itemprop="name">K. Hirzel</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Gisela Link" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/2"><span itemprop="name">G. Link</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stephan A. Eisler" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/3"><span itemprop="name">S. Eisler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Tanja Hägele" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/4"><span itemprop="name">T. Hägele</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Matthew A. H. Parson" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/5"><span itemprop="name">M. Parson</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="John E. Burke" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/6"><span itemprop="name">J. Burke</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/7"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Thomas A. Leonard" itemprop="url" href="/person/102d0848a747c7cb4ca815d283aff9e38/author/8"><span itemprop="name">T. Leonard</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Proceedings of the National Academy of Sciences</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">120 </span></span>(<span itemprop="issueNumber">7</span>):
<span itemprop="pagination">e2212909120</span></em> </span>(<em><span>2023<meta content="2023" itemprop="datePublished"/></span></em>)</span>Tue Feb 07 08:59:43 CET 2023Proceedings of the National Academy of Sciences7e2212909120PKD autoinhibition in trans regulates activation loop autophosphorylation in cis12020232023 hausser izi Endocytosis of AMPA receptors: Role in neurological conditionshttps://puma.ub.uni-stuttgart.de/bibtex/25a35c9ffb77a14ff06fb7c13f11d196a/cristianocristiano2023-01-25T09:00:30+01:002022 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Norbert Bencsik" itemprop="url" href="/person/18134fc0b4edebe0596090f75620f6c8a/author/0"><span itemprop="name">N. Bencsik</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Carlos Omar Oueslati Morales" itemprop="url" href="/person/18134fc0b4edebe0596090f75620f6c8a/author/1"><span itemprop="name">C. Oueslati Morales</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/18134fc0b4edebe0596090f75620f6c8a/author/2"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Katalin Schlett" itemprop="url" href="/person/18134fc0b4edebe0596090f75620f6c8a/author/3"><span itemprop="name">K. Schlett</span></a></span></span>. </span><span class="additional-entrytype-information"><em><span itemprop="publisher">Academic Press</span>, </em><span itemtype="http://schema.org/Book" itemscope="itemscope" itemprop="isPartOf"></span>(<em><span>2022<meta content="2022" itemprop="datePublished"/></span></em>)</span>Wed Jan 25 09:00:30 CET 2023Progress in Molecular Biology and Translational ScienceEndocytosis of AMPA receptors: Role in neurological conditions20222022 hausser izi ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cellshttps://puma.ub.uni-stuttgart.de/bibtex/2c7705e67a91e5be1873cf1aa4dc28045/cristianocristiano2022-01-24T10:29:24+01:002022 EXC2075 hausser izi morrison pn2 simtech <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Cathrin Hagenlocher" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/0"><span itemprop="name">C. Hagenlocher</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Robin Siebert" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/1"><span itemprop="name">R. Siebert</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Bruno Taschke" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/2"><span itemprop="name">B. Taschke</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Senait Wieske" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/3"><span itemprop="name">S. Wieske</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/4"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Markus Rehm" itemprop="url" href="/person/1040e11e469229e3642b9b49a135a599c/author/5"><span itemprop="name">M. Rehm</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Cell Death Discovery</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">8 </span></span>(<span itemprop="issueNumber">1</span>):
<span itemprop="pagination">34</span></em> </span>(<em><span>Jan 24, 2022<meta content="Jan 24, 2022" itemprop="datePublished"/></span></em>)</span>Mon Jan 24 10:29:24 CET 2022Cell Death Discoveryjan134ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells820222022 EXC2075 hausser izi morrison pn2 simtech 24ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells | Cell Death DiscoveryProtein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neuronshttps://puma.ub.uni-stuttgart.de/bibtex/21af4fdd4388cbce2e17a56552611f821/cristianocristiano2021-09-27T10:46:43+02:002021 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Carlos O. Oueslati Morales" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/0"><span itemprop="name">C. Oueslati Morales</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Attila Ignácz" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/1"><span itemprop="name">A. Ignácz</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Norbert Bencsik" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/2"><span itemprop="name">N. Bencsik</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Zsofia Sziber" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/3"><span itemprop="name">Z. Sziber</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Anikó Erika Rátkai" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/4"><span itemprop="name">A. Rátkai</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Wolfgang S. Lieb" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/5"><span itemprop="name">W. Lieb</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stephan A. Eisler" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/6"><span itemprop="name">S. Eisler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Attila Szűcs" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/7"><span itemprop="name">A. Szűcs</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Katalin Schlett" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/8"><span itemprop="name">K. Schlett</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/198baadcf81d0640ac6e33d104d819ec0/author/9"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Traffic</span>, </em> </span>(<em><span>2021<meta content="2021" itemprop="datePublished"/></span></em>)</span>Mon Sep 27 10:46:43 CEST 2021Trafficn/aProtein Kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neuronsn/a20212021 hausser izi Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPshttps://puma.ub.uni-stuttgart.de/bibtex/256816dfb091c5e94a8e7f4fd2ca00e61/cristianocristiano2020-06-02T15:27:31+02:002020 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Natalia Pacheco-Fernandez" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/0"><span itemprop="name">N. Pacheco-Fernandez</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Mehrshad Pakdel" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/1"><span itemprop="name">M. Pakdel</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Birgit Blank" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/2"><span itemprop="name">B. Blank</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Ismael Sanchez-Gonzalez" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/3"><span itemprop="name">I. Sanchez-Gonzalez</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Kathrin Weber" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/4"><span itemprop="name">K. Weber</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Mai Ly Tran" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/5"><span itemprop="name">M. Tran</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Tobias Karl-Heinz Hecht" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/6"><span itemprop="name">T. Hecht</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Renate Gautsch" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/7"><span itemprop="name">R. Gautsch</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Gisela Beck" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/8"><span itemprop="name">G. Beck</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Franck Perez" itemprop="url" href="/person/19c492400399fbdac8589bc562820dbb6/author/9"><span itemprop="name">F. Perez</span></a></span></span> and 3 other author(s). </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Journal of Cell Biology</span>, </em> </span>(<em><span>June 2020<meta content="June 2020" itemprop="datePublished"/></span></em>)</span>Tue Jun 02 15:27:31 CEST 2020Journal of Cell Biologyjun8Nucleobindin-1 regulates {ECM} degradation by promoting intra-Golgi trafficking of {MMPs}21920202020 hausser izi Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs | Journal of Cell Biology | Rockefeller University PressDeletion of Protein Kinase D3 Promotes Liver Fibrosis in Micehttps://puma.ub.uni-stuttgart.de/bibtex/2c5d4dc243da76b91d79eca8caf8ef982/cristianocristiano2020-02-12T09:28:49+01:002020 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Shuya Zhang" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/0"><span itemprop="name">S. Zhang</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Huan Liu" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/1"><span itemprop="name">H. Liu</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Meimei Yin" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/2"><span itemprop="name">M. Yin</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Xiuying Pei" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/3"><span itemprop="name">X. Pei</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/4"><span itemprop="name">A. Hausser</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Eri Ishikawa" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/5"><span itemprop="name">E. Ishikawa</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Sho Yamasaki" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/6"><span itemprop="name">S. Yamasaki</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Zheng Gen Jin" itemprop="url" href="/person/1fb9ca00a772dea82e45c221c47f599a2/author/7"><span itemprop="name">Z. Jin</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Hepatology</span>, </em> </span>(<em><span>February 2020<meta content="February 2020" itemprop="datePublished"/></span></em>)</span>Wed Feb 12 09:28:49 CET 2020Hepatologyfebhep.31176{Deletion of Protein Kinase D3 Promotes Liver Fibrosis in Mice}20202020 hausser izi Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28https://puma.ub.uni-stuttgart.de/bibtex/2aa65ac85b72af318d0388742849e371f/cristianocristiano2020-01-24T10:08:59+01:002020 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Ines Müller" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/0"><span itemprop="name">I. Müller</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Elwira Strozyk" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/1"><span itemprop="name">E. Strozyk</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Sebastian Schindler" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/2"><span itemprop="name">S. Schindler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stefan Beissert" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/3"><span itemprop="name">S. Beissert</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Htoo Zarni Oo" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/4"><span itemprop="name">H. Oo</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Thomas Sauter" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/5"><span itemprop="name">T. Sauter</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Philippe Lucarelli" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/6"><span itemprop="name">P. Lucarelli</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Sebastian Raeth" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/7"><span itemprop="name">S. Raeth</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/8"><span itemprop="name">A. Hausser</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Nader Al Nakouzi" itemprop="url" href="/person/15ac6878b6d39a87e87fa214142aaf2ae/author/9"><span itemprop="name">N. Al Nakouzi</span></a></span></span> and 9 other author(s). </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Molecular Cell</span>, </em> </span>(<em><span>January 2020<meta content="January 2020" itemprop="datePublished"/></span></em>)</span>Fri Jan 24 10:08:59 CET 2020Molecular Celljan{Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28}20202020 hausser izi Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPaseshttps://puma.ub.uni-stuttgart.de/bibtex/2dee8db8b618f9b2d7ccb594574347770/cristianocristiano2019-11-25T15:22:37+01:002019 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A. Olayioye" itemprop="url" href="/person/124e9829603ab61b495a15b597892b739/author/0"><span itemprop="name">M. Olayioye</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Bettina Noll" itemprop="url" href="/person/124e9829603ab61b495a15b597892b739/author/1"><span itemprop="name">B. Noll</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/124e9829603ab61b495a15b597892b739/author/2"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Cells</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">8 </span></span>(<span itemprop="issueNumber">12</span>):
<span itemprop="pagination">1478</span></em> </span>(<em><span>November 2019<meta content="November 2019" itemprop="datePublished"/></span></em>)</span>Mon Nov 25 15:22:37 CET 2019Cellsnov121478{Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases}820192019 hausser izi olayioye {\textless}p{\textgreater}As membrane-associated master regulators of cytoskeletal remodeling, Rho GTPases coordinate a wide range of biological processes such as cell adhesion, motility, and polarity. In the last years, Rho GTPases have also been recognized to control intracellular membrane sorting and trafficking steps directly; however, how Rho GTPase signaling is regulated at endomembranes is still poorly understood. In this review, we will specifically address the local Rho GTPase pools coordinating intracellular membrane trafficking with a focus on the endo- and exocytic pathways. We will further highlight the spatiotemporal molecular regulation of Rho signaling at endomembrane sites through Rho regulatory proteins, the GEFs and GAPs. Finally, we will discuss the contribution of dysregulated Rho signaling emanating from endomembranes to the development and progression of cancer.{\textless}/p{\textgreater}The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cellshttps://puma.ub.uni-stuttgart.de/bibtex/21f04a45d2735147a629cbbae8a22e546/cristianocristiano2019-11-20T15:36:15+01:002019 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Wolfgang Sebastian Lieb" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/0"><span itemprop="name">W. Lieb</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Cristiana Lungu" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/1"><span itemprop="name">C. Lungu</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Raluca Tamas" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/2"><span itemprop="name">R. Tamas</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Hannah Berreth" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/3"><span itemprop="name">H. Berreth</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Philipp Rathert" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/4"><span itemprop="name">P. Rathert</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Peter Storz" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/5"><span itemprop="name">P. Storz</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A. Olayioye" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/6"><span itemprop="name">M. Olayioye</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1dcf3c5e17d5027656d00493bae2a09aa/author/7"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">International Journal of Cancer</span>, </em> </span>(<em><span>November 2019<meta content="November 2019" itemprop="datePublished"/></span></em>)</span>Wed Nov 20 15:36:15 CET 2019International Journal of Cancernovijc.32798{The GEF‐H1/PKD3 signaling pathway promotes the maintenance of triple negative breast cancer stem cells}20192019 hausser izi olayioye Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi networkhttps://puma.ub.uni-stuttgart.de/bibtex/2197ca1b5b8376025110ee46eac849eb1/cristianocristiano2019-08-01T09:38:03+02:002019 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Julia von Blume" itemprop="url" href="/person/171e10c7481c6f208ee35c5ae07d73ad9/author/0"><span itemprop="name">J. von Blume</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/171e10c7481c6f208ee35c5ae07d73ad9/author/1"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">FEBS Letters</span>, </em> </span>(<em><span>July 2019<meta content="July 2019" itemprop="datePublished"/></span></em>)</span>Thu Aug 01 09:38:03 CEST 2019FEBS Lettersjul1873--3468.13552{Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network}20192019 hausser izi The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory functionhttps://puma.ub.uni-stuttgart.de/bibtex/223749a6eba7da87b013af8dba4d7dd89/cristianocristiano2018-08-28T09:21:02+02:002018 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Antje Jensch" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/0"><span itemprop="name">A. Jensch</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Yannick Frey" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/1"><span itemprop="name">Y. Frey</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Katharina Bitschar" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/2"><span itemprop="name">K. Bitschar</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Patrick Weber" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/3"><span itemprop="name">P. Weber</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Simone Schmid" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/4"><span itemprop="name">S. Schmid</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/5"><span itemprop="name">A. Hausser</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A. Olayioye" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/6"><span itemprop="name">M. Olayioye</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Nicole E. Radde" itemprop="url" href="/person/15be5d3ed6b8348c67cc7d74dc513751c/author/7"><span itemprop="name">N. Radde</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Journal of Biological Chemistry</span>, </em> </span>(<em><span>July 2018<meta content="July 2018" itemprop="datePublished"/></span></em>)</span>Tue Aug 28 09:21:02 CEST 2018Journal of Biological Chemistryjuljbc.RA118.003787{The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function}20182018 hausser izi olayioye Many newly synthesized cellular proteins pass through the Golgi complex from where secretory transport carriers sort them to the plasma membrane and the extracellular environment. The formation of these secretory carriers at the trans-Golgi network is promoted by the Protein Kinase D (PKD) family of serine-threonine kinases. Here, using mathematical modeling and experimental validation of the PKD activation and substrate phosphorylation kinetics, we reveal that the expression level of the PKD substrate Deleted in Liver Cancer 1 (DLC1), a Rho GTPase activating protein that is inhibited by PKD-mediated phosphorylation, determines PKD activity at the Golgi membranes. RNAi-mediated depletion of DLC1 reduced PKD activity in a Rho-Rho-associated protein kinase (ROCK)-dependent manner, impaired the exocytosis of the cargo protein horse radish peroxidase and was associated with the accumulation of the small GTPase RAB6 on Golgi membranes, indicating a protein-trafficking defect. In summary, our findings reveal that DLC1 maintains basal activation of PKD at the Golgi and Golgi secretory activity, in part by down-regulating Rho-ROCK signaling. We propose that PKD senses cytoskeletal changes downstream of DLC1 to coordinate Rho signaling with Golgi secretory function.A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesionshttps://puma.ub.uni-stuttgart.de/bibtex/200a1c11b1422a81a05edf897649b1df5/cristianocristiano2018-07-25T17:09:22+02:002018 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stephan A Eisler" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/0"><span itemprop="name">S. Eisler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Filipa Curado" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/1"><span itemprop="name">F. Curado</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Gisela Link" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/2"><span itemprop="name">G. Link</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Sarah Schulz" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/3"><span itemprop="name">S. Schulz</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Melanie Noack" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/4"><span itemprop="name">M. Noack</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Maren Steinke" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/5"><span itemprop="name">M. Steinke</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A Olayioye" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/6"><span itemprop="name">M. Olayioye</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1601203f2329e1e33362764f0489d9271/author/7"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">eLife</span>, </em> </span>(<em><span>July 2018<meta content="July 2018" itemprop="datePublished"/></span></em>)</span>Wed Jul 25 17:09:22 CEST 2018eLifejul{A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions}720182018 hausser izi olayioye {\textless}p{\textgreater}Protein kinase D (PKD) is a family of serine/threonine kinases that is required for the structural integrity and function of the Golgi complex. Despite its importance in the regulation of Golgi function, the molecular mechanisms regulating PKD activity are still incompletely understood. Using the genetically encoded PKD activity reporter G-PKDrep we now uncover a Rho signaling network comprising GEF-H1, the RhoGAP DLC3, and the Rho effector PLCe that regulate the activation of PKD at trans-Golgi membranes. We further show that this molecular network coordinates the formation of TGN-derived Rab6-positive transport carriers delivering cargo for localized exocytosis at focal adhesions.{\textless}/p{\textgreater}Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cellshttps://puma.ub.uni-stuttgart.de/bibtex/2eb2d860b341571ae15e383cb0c7053bd/cristianocristiano2018-02-01T16:26:29+01:002012 hausser izi pfizenmaier <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Mirita Franz-Wachtel" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/0"><span itemprop="name">M. Franz-Wachtel</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stephan A. Eisler" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/1"><span itemprop="name">S. Eisler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Karsten Krug" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/2"><span itemprop="name">K. Krug</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Silke Wahl" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/3"><span itemprop="name">S. Wahl</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Alejandro Carpy" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/4"><span itemprop="name">A. Carpy</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Alfred Nordheim" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/5"><span itemprop="name">A. Nordheim</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Klaus Pfizenmaier" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/6"><span itemprop="name">K. Pfizenmaier</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/7"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Boris Macek" itemprop="url" href="/person/126d5ed6bc6c93a9f05ae6bd36827403e/author/8"><span itemprop="name">B. Macek</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Molecular & Cellular Proteomics</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">11 </span></span>(<span itemprop="issueNumber">5</span>):
<span itemprop="pagination">160--170</span></em> </span>(<em><span>May 2012<meta content="May 2012" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:26:29 CET 2018Molecular {\&} Cellular Proteomicsmay5160--170{Global Detection of Protein Kinase D-dependent Phosphorylation Events in Nocodazole-treated Human Cells}1120122012 hausser izi pfizenmaier Protein kinase D (PKD) is a cytosolic serine/threonine kinase implicated in regulation of several cellular processes such as response to oxidative stress, directed cell migration, invasion, differentiation, and fission of the vesicles at the trans-Golgi network. Its variety of functions must be mediated by numerous substrates; however, only a couple of PKD substrates have been identified so far. Here we perform stable isotope labeling of amino acids in cell culture-based quantitative phosphoproteomic analysis to detect phosphorylation events dependent on PKD1 activity in human cells. We compare relative phosphorylation levels between constitutively active and kinase dead PKD1 strains of HEK293 cells, both treated with nocodazole, a microtubule-depolymerizing reagent that disrupts the Golgi complex and activates PKD1. We identify 124 phosphorylation sites that are significantly down-regulated upon decrease of PKD1 activity and show that the PKD target motif is significantly enriched among down-regulated phosphorylation events, pointing to the presence of direct PKD1 substrates. We further perform PKD1 target motif analysis, showing that a proline residue at position +1 relative to the phosphorylation site serves as an inhibitory cue for PKD1 activity. Among PKD1-dependent phosphorylation events, we detect predominantly proteins with localization at Golgi membranes and function in protein sorting, among them several sorting nexins and members of the insulin-like growth factor 2 receptor pathway. This study presents the first global detection of PKD1-dependent phosphorylation events and provides a wealth of information for functional follow-up of PKD1 activity upon disruption of the Golgi network in human cells.Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT networkhttps://puma.ub.uni-stuttgart.de/bibtex/2af8579d3cf4afdbfc643f2d8f5f97f63/cristianocristiano2018-02-01T16:26:29+01:002012 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A. Olayioye" itemprop="url" href="/person/1be29145db42e71d2fda3c6e9028a8ecf/author/0"><span itemprop="name">M. Olayioye</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1be29145db42e71d2fda3c6e9028a8ecf/author/1"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">1821 </span></span>(<span itemprop="issueNumber">8</span>):
<span itemprop="pagination">1096--1103</span></em> </span>(<em><span>August 2012<meta content="August 2012" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:26:29 CET 2018Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipidsaug81096--1103{Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network}182120122012 hausser izi olayioye Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine-threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, the ceramide transfer protein, play central roles in coordinating these processes by fine-tuning the local membrane lipid composition to maintain Golgi secretory function. This article is part of a Special Issue entitled Lipids and Vesicular Transport. {\textcopyright} 2011 Elsevier B.V.Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1https://puma.ub.uni-stuttgart.de/bibtex/21365a61ca8d350bc9dc095371cdf6fca/cristianocristiano2018-02-01T16:25:50+01:002012 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Cordula Kempkes" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/0"><span itemprop="name">C. Kempkes</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Anke Rattenholl" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/1"><span itemprop="name">A. Rattenholl</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Jörg Buddenkotte" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/2"><span itemprop="name">J. Buddenkotte</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Elwira Strozyk" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/3"><span itemprop="name">E. Strozyk</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Jürgen Eberle" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/4"><span itemprop="name">J. Eberle</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/5"><span itemprop="name">A. Hausser</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Ferda Cevikbas" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/6"><span itemprop="name">F. Cevikbas</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stefan W. Schneider" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/7"><span itemprop="name">S. Schneider</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Martin Steinhoff" itemprop="url" href="/person/15686bb18f3e14ca27c5814231933d716/author/8"><span itemprop="name">M. Steinhoff</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Journal of Investigative Dermatology</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">132 </span></span>(<span itemprop="issueNumber">2</span>):
<span itemprop="pagination">375--384</span></em> </span>(<em><span>February 2012<meta content="February 2012" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:25:50 CET 2018Journal of Investigative Dermatologyfeb2375--384{Proteinase-activated receptors 1 and 2 regulate invasive behavior of human melanoma cells via activation of protein kinase D1}13220122012 hausser izi Recent studies have indicated an important role of proteinases and proteinase-activated receptors (PARs) in tumorigenesis. Although a role for PARs has been described in various skin tumors including melanoma, the underlying cellular mechanisms have not been understood. Recent studies have suggested PAR(1) as a regulator of melanoma cell growth and metastasis by affecting angiogenic and invasive factors. Moreover, changes in the expression patterns of PAR(1) and PAR(2) correlate with skin cancer progression, and PAR(1) is overexpressed in melanoma. Therefore, we sought to elucidate the putative role of PAR(1)- and PAR(2)-mediated signal transduction pathways during melanoma progression. Activation of both PAR(1) and PAR(2) led to rapid phosphorylation of protein kinase D1 (PKD1) in cultured WM9 melanoma cells. PKD1 is known to be involved in cell migration, integrin regulation, and intracellular vesicle transport. Downregulation of PKD1 by siRNA resulted in diminished proliferation, decreased $\alpha$v$\beta$3 integrin regulation, and secretion of pro-angiogenic chemokine IL-8 in WM9 cells. In conclusion, our results show that PAR(1) and PAR(2) are involved in WM9 cell proliferation and secretion of IL-8 by activation of PKD1. Inactivation of the PKD1 pathway may be beneficial for the inhibition of PAR-induced melanoma proliferation and for maintenance of the inflammatory tumor environment.G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-networkhttps://puma.ub.uni-stuttgart.de/bibtex/2bfa6002b317c3aa9b040559903f0d488/cristianocristiano2018-02-01T16:21:30+01:002012 hausser izi pfizenmaier <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Stephan A. Eisler" itemprop="url" href="/person/174475a00f79590f4090534ef5e1a1ce0/author/0"><span itemprop="name">S. Eisler</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Yannick F. Fuchs" itemprop="url" href="/person/174475a00f79590f4090534ef5e1a1ce0/author/1"><span itemprop="name">Y. Fuchs</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Klaus Pfizenmaier" itemprop="url" href="/person/174475a00f79590f4090534ef5e1a1ce0/author/2"><span itemprop="name">K. Pfizenmaier</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/174475a00f79590f4090534ef5e1a1ce0/author/3"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Biotechnology Journal</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">7 </span></span>(<span itemprop="issueNumber">1</span>):
<span itemprop="pagination">148--154</span></em> </span>(<em><span>January 2012<meta content="January 2012" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:21:30 CET 2018Biotechnology Journaljan1148--154{G-PKDrep-live, a genetically encoded FRET reporter to measure PKD activity at the trans-Golgi-network}720122012 hausser izi pfizenmaier The serine/threonine protein kinase D (PKD) is recruited to the trans-Golgi-network (TGN) by interaction with diacylglycerol (DAG) and Arf1 and promotes the fission of vesicles containing cargo destined for the plasma membrane. PKD activation is mediated by PKC(-induced phosphorylation. However, signaling pathways that activate PKD specifically at the TGN are only poorly characterized. Recently we created G-PKDrep, a genetically encoded fluorescent reporter for PKD activity at the TGN in fixed cells. To establish a reporter useful for monitoring Golgi-specific PKD activity in living cells we now refined G-PKDrep to generate G-PKDrep-live. Specifically, phosphorylation of G-PKDrep-live expressed in mammalian cells results in changes of fluorescence resonance energy transfer (FRET), and allows for indirect imaging of PKD activity. In a proof-of-principle experiment using phorbolester treatment, we demonstrate the reporter's capability to track rapid activation of PKD at the TGN. Furthermore, activation-induced FRET changes are reversed by treatment with PKD-specific pharmacological inhibitors. Thus, the newly developed reporter G-PKDrep-live is a suitable tool to visualize dynamic changes in PKD activity at the TGN in living cells. See accompanying commentary by Gautam DOI: 10.1002/biot.201100424.GIT1 Phosphorylation on Serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activityhttps://puma.ub.uni-stuttgart.de/bibtex/2f56de14f6ebb6cc358905ac6aee5ef5a/cristianocristiano2018-02-01T16:17:47+01:002012 hausser izi olayioye <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Bettina Huck" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/0"><span itemprop="name">B. Huck</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Ralf Kemkemer" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/1"><span itemprop="name">R. Kemkemer</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Mirita Franz-Wachtel" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/2"><span itemprop="name">M. Franz-Wachtel</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Boris Macek" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/3"><span itemprop="name">B. Macek</span></a></span>, </span><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/4"><span itemprop="name">A. Hausser</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Monilola A. Olayioye" itemprop="url" href="/person/1f0194563efb247d6c821123302105ff1/author/5"><span itemprop="name">M. Olayioye</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">Journal of Biological Chemistry</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">287 </span></span>(<span itemprop="issueNumber">41</span>):
<span itemprop="pagination">34604--34613</span></em> </span>(<em><span>October 2012<meta content="October 2012" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:17:47 CET 2018Journal of Biological Chemistryoct4134604--34613{GIT1 Phosphorylation on Serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity}28720122012 hausser izi olayioye The continuous assembly and disassembly of focal adhesions is required for efficient cell spreading and migration. The G-protein-coupled receptor kinase-interacting protein 1 (GIT1) is a multidomain protein whose dynamic localization to sites of cytoskeletal remodeling is critically involved in the regulation of these processes. Here we provide evidence that the subcellular localization of GIT1 is regulated by protein kinase D3 (PKD3) through direct phosphorylation on serine 46. GIT1 phosphorylation on serine 46 was abrograted by PKD3 depletion, thereby identifying GIT1 as the first specific substrate for this kinase. A GIT1 S46D phosphomimetic mutant localized to motile, paxillin-positive cytoplasmic complexes, whereas the phosphorylation-deficient GIT1 S46A was enriched in focal adhesions. We propose that phosphorylation of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin trafficking, and cellular protrusive activity are regulated.Physiological functions of protein kinase D in vivohttps://puma.ub.uni-stuttgart.de/bibtex/2ceafa98e9f709487b535626ec9cee2a5/cristianocristiano2018-02-01T16:14:52+01:002013 hausser izi <span data-person-type="author" class="authorEditorList "><span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Kornelia Ellwanger" itemprop="url" href="/person/124c918cc504f055861388337b507eedc/author/0"><span itemprop="name">K. Ellwanger</span></a></span>, </span> and <span><span itemtype="http://schema.org/Person" itemscope="itemscope" itemprop="author"><a title="Angelika Hausser" itemprop="url" href="/person/124c918cc504f055861388337b507eedc/author/1"><span itemprop="name">A. Hausser</span></a></span></span>. </span><span class="additional-entrytype-information"><span itemtype="http://schema.org/PublicationIssue" itemscope="itemscope" itemprop="isPartOf"><em><span itemprop="journal">IUBMB Life</span>, </em> <em><span itemtype="http://schema.org/PublicationVolume" itemscope="itemscope" itemprop="isPartOf"><span itemprop="volumeNumber">65 </span></span>(<span itemprop="issueNumber">2</span>):
<span itemprop="pagination">98--107</span></em> </span>(<em><span>February 2013<meta content="February 2013" itemprop="datePublished"/></span></em>)</span>Thu Feb 01 16:14:52 CET 2018IUBMB Lifefeb298--107{Physiological functions of protein kinase D in vivo}6520132013 hausser izi The cellular functions of the serine/threonine protein kinase D (PKD) have been extensively studied within the last decade and distinct roles such as fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription have been correlated with this kinase family. Here, we highlight the current state of in vivo studies on PKD function with a focus on animal models and discuss the molecular basis of the observed phenotypic characteristics associated with this kinase family.