%0 Journal Article %1 Maier2013 %A Maier, Olaf %A Fischer, Roman %A Agresti, Cristina %A Pfizenmaier, Klaus %D 2013 %J Biochemical and Biophysical Research Communications %K 2013 izi pfizenmaier %N 2 %P 336--341 %R 10.1016/j.bbrc.2013.09.083 %T TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress %U http://www.ncbi.nlm.nih.gov/pubmed/24076392 %V 440 %X The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells. Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby providing a potential mechanism for the neuroprotective role of TNFR2 in oligodendrocyte progenitor cells. © 2013 Elsevier Inc.

@article{Maier2013, abstract = {The neuroprotective role of TNF receptor 2 (TNFR2) has been shown in various studies. However, a direct role of TNFR2 in oligodendrocyte function has not yet been demonstrated. Using primary oligodendrocytes of transgenic mice expressing human TNFR2, we show here that TNFR2 is primarily expressed on oligodendrocyte progenitor cells. Interestingly, preconditioning with a TNFR2 agonist protects these cells from oxidative stress, presumably by increasing the gene expression of distinct anti-apoptotic and detoxifying proteins, thereby providing a potential mechanism for the neuroprotective role of TNFR2 in oligodendrocyte progenitor cells. {\textcopyright} 2013 Elsevier Inc.}, added-at = {2023-06-29T13:07:55.000+0200}, author = {Maier, Olaf and Fischer, Roman and Agresti, Cristina and Pfizenmaier, Klaus}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2dc270cae7c87e68305edd14cc54b5bfa/fabian}, doi = {10.1016/j.bbrc.2013.09.083}, interhash = {ba6aa98bb53846fa6bd4340440024f2b}, intrahash = {dc270cae7c87e68305edd14cc54b5bfa}, issn = {0006291X}, journal = {Biochemical and Biophysical Research Communications}, keywords = {2013 izi pfizenmaier}, month = oct, number = 2, pages = {336--341}, pmid = {24076392}, timestamp = {2023-06-29T13:07:55.000+0200}, title = {{TNF receptor 2 protects oligodendrocyte progenitor cells against oxidative stress}}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24076392}, volume = 440, year = 2013 }