%0 Journal Article %1 Eisler2018 %A Eisler, Stephan A %A Curado, Filipa %A Link, Gisela %A Schulz, Sarah %A Noack, Melanie %A Steinke, Maren %A Olayioye, Monilola A %A Hausser, Angelika %D 2018 %J eLife %K 2018 hausser izi olayioye %R 10.7554/eLife.35907 %T A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions %U http://www.ncbi.nlm.nih.gov/pubmed/30028295 %V 7 %X \textlessp\textgreaterProtein kinase D (PKD) is a family of serine/threonine kinases that is required for the structural integrity and function of the Golgi complex. Despite its importance in the regulation of Golgi function, the molecular mechanisms regulating PKD activity are still incompletely understood. Using the genetically encoded PKD activity reporter G-PKDrep we now uncover a Rho signaling network comprising GEF-H1, the RhoGAP DLC3, and the Rho effector PLCe that regulate the activation of PKD at trans-Golgi membranes. We further show that this molecular network coordinates the formation of TGN-derived Rab6-positive transport carriers delivering cargo for localized exocytosis at focal adhesions.\textless/p\textgreater

@article{Eisler2018, abstract = {{\textless}p{\textgreater}Protein kinase D (PKD) is a family of serine/threonine kinases that is required for the structural integrity and function of the Golgi complex. Despite its importance in the regulation of Golgi function, the molecular mechanisms regulating PKD activity are still incompletely understood. Using the genetically encoded PKD activity reporter G-PKDrep we now uncover a Rho signaling network comprising GEF-H1, the RhoGAP DLC3, and the Rho effector PLCe that regulate the activation of PKD at trans-Golgi membranes. We further show that this molecular network coordinates the formation of TGN-derived Rab6-positive transport carriers delivering cargo for localized exocytosis at focal adhesions.{\textless}/p{\textgreater}}, added-at = {2023-06-29T13:07:55.000+0200}, author = {Eisler, Stephan A and Curado, Filipa and Link, Gisela and Schulz, Sarah and Noack, Melanie and Steinke, Maren and Olayioye, Monilola A and Hausser, Angelika}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/200a1c11b1422a81a05edf897649b1df5/fabian}, doi = {10.7554/eLife.35907}, interhash = {601203f2329e1e33362764f0489d9271}, intrahash = {00a1c11b1422a81a05edf897649b1df5}, issn = {2050-084X}, journal = {eLife}, keywords = {2018 hausser izi olayioye}, month = jul, pmid = {30028295}, timestamp = {2023-06-29T13:07:55.000+0200}, title = {{A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions}}, url = {http://www.ncbi.nlm.nih.gov/pubmed/30028295}, volume = 7, year = 2018 }