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Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

, , und . BMC Systems Biology 11 (1): 11 (25.01.2017)

Zusammenfassung

Positive and negative feedback loops are ubiquitous motifs in biochemical signaling pathways. The mitogen-activated protein kinase (MAPK) pathway module is part of many distinct signaling networks and comprises several of these motifs, whose functioning depends on the cell line at hand and on the particular context.

Links und Ressourcen

DOI:
10.1186/s12918-017-0392-6
URL:
BibTeX-Schlüssel:
jensch2017samplingbased
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