Article,

Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15

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OncoImmunology, 1 (7): 1213--1214 (October 2012)
DOI: 10.4161/onci.20824

Abstract

Under physiological conditions, the trans-presentation of interleukin-15 (IL-15) by the IL-15 receptor alpha on the cell surface allows to confine and tune the IL-15-mediated immune responses. Therefore, targeting strategies that mimic this situation at the tumor sites appear especially promising for anticancer immunotherapy.

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