%0 Journal Article %1 eikmanns_pyruvate_2014 %A Eikmanns, Bernhard J. %A Blombach, Bastian %D 2014 %J J. Biotechnol. %K Acid, Amino Butanols, Complex, Corynebacterium Dehydrogenase Engineering, Isobutanol Metabolic Pyruvate Pyruvic Valine, acid and complex dehydrogenase engineering, glutamicum, myown organic production, %P 339--345 %R 10.1016/j.jbiotec.2013.12.019 %T The pyruvate dehydrogenase complex of Corynebacterium glutamicum: an attractive target for metabolic engineering %V 192 Pt B %X The pyruvate dehydrogenase complex (PDHC) catalyzes the oxidative thiamine pyrophosphate-dependent decarboxylation of pyruvate to acetyl-CoA and CO2. Since pyruvate is a key metabolite of the central metabolism and also the precursor for several relevant biotechnological products, metabolic engineering of this multienzyme complex is a promising strategy to improve microbial production processes. This review summarizes the current knowledge and achievements on metabolic engineering approaches to tailor the PDHC of Corynebacterium glutamicum for the bio-based production of l-valine, 2-ketosiovalerate, pyruvate, succinate and isobutanol and to improve l-lysine production.

@article{eikmanns_pyruvate_2014, abstract = {The pyruvate dehydrogenase complex (PDHC) catalyzes the oxidative thiamine pyrophosphate-dependent decarboxylation of pyruvate to acetyl-CoA and CO2. Since pyruvate is a key metabolite of the central metabolism and also the precursor for several relevant biotechnological products, metabolic engineering of this multienzyme complex is a promising strategy to improve microbial production processes. This review summarizes the current knowledge and achievements on metabolic engineering approaches to tailor the PDHC of Corynebacterium glutamicum for the bio-based production of l-valine, 2-ketosiovalerate, pyruvate, succinate and isobutanol and to improve l-lysine production.}, added-at = {2018-02-09T13:18:17.000+0100}, author = {Eikmanns, Bernhard J. and Blombach, Bastian}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2ed56a8ffa25fcb7fe239b276b7e52493/bastian}, doi = {10.1016/j.jbiotec.2013.12.019}, interhash = {11bc42d6baae0b586acdbed655538eb6}, intrahash = {ed56a8ffa25fcb7fe239b276b7e52493}, issn = {1873-4863}, journal = {J. Biotechnol.}, keywords = {Acid, Amino Butanols, Complex, Corynebacterium Dehydrogenase Engineering, Isobutanol Metabolic Pyruvate Pyruvic Valine, acid and complex dehydrogenase engineering, glutamicum, myown organic production,}, language = {eng}, month = dec, pages = {339--345}, pmid = {24486441}, shorttitle = {The pyruvate dehydrogenase complex of {Corynebacterium} glutamicum}, timestamp = {2018-02-09T12:18:56.000+0100}, title = {The pyruvate dehydrogenase complex of {Corynebacterium} glutamicum: an attractive target for metabolic engineering}, volume = {192 Pt B}, year = 2014 }