%0 Journal Article %1 Ateş2023 %A Ates, Filiz %A Marquetand, Justus %A Zimmer, Manuela %D 2023 %J Scientific Reports %K grk2198 isd myown %N 1 %P 20062 %R 10.1038/s41598-023-47468-z %T Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography %U https://doi.org/10.1038/s41598-023-47468-z %V 13 %X Aging leads to a decline in muscle mass and force-generating capacity. Ultrasound shear wave elastography (SWE) is a non-invasive method to capture age-related muscular adaptation. This study assessed biceps brachii muscle (BB) mechanics, hypothesizing that shear elastic modulus reflects (i) passive muscle force increase imposed by length change, (ii) activation-dependent mechanical changes, and (iii) differences between older and younger individuals. Fourteen healthy volunteers aged 60--80 participated. Shear elastic modulus, surface electromyography, and elbow torque were measured at five elbow positions in passive and active states. Data collected from young adults aged 20--40 were compared. The BB passive shear elastic modulus increased from flexion to extension, with the older group exhibiting up to 52.58\% higher values. Maximum elbow flexion torque decreased in extended positions, with the older group 23.67\% weaker. Significant effects of elbow angle, activity level, and age on total and active shear elastic modulus were found during submaximal contractions. The older group had 20.25\% lower active shear elastic modulus at 25\% maximum voluntary contraction. SWE effectively quantified passive and activation-dependent BB mechanics, detecting age-related alterations at rest and during low-level activities. These findings suggest shear elastic modulus as a promising biomarker for identifying altered muscle mechanics in aging.

@article{Ateş2023, abstract = {Aging leads to a decline in muscle mass and force-generating capacity. Ultrasound shear wave elastography (SWE) is a non-invasive method to capture age-related muscular adaptation. This study assessed biceps brachii muscle (BB) mechanics, hypothesizing that shear elastic modulus reflects (i) passive muscle force increase imposed by length change, (ii) activation-dependent mechanical changes, and (iii) differences between older and younger individuals. Fourteen healthy volunteers aged 60--80 participated. Shear elastic modulus, surface electromyography, and elbow torque were measured at five elbow positions in passive and active states. Data collected from young adults aged 20--40 were compared. The BB passive shear elastic modulus increased from flexion to extension, with the older group exhibiting up to 52.58{\%} higher values. Maximum elbow flexion torque decreased in extended positions, with the older group 23.67{\%} weaker. Significant effects of elbow angle, activity level, and age on total and active shear elastic modulus were found during submaximal contractions. The older group had 20.25{\%} lower active shear elastic modulus at 25{\%} maximum voluntary contraction. SWE effectively quantified passive and activation-dependent BB mechanics, detecting age-related alterations at rest and during low-level activities. These findings suggest shear elastic modulus as a promising biomarker for identifying altered muscle mechanics in aging.}, added-at = {2024-02-13T22:12:37.000+0100}, author = {Ate{\c{s}}, Filiz and Marquetand, Justus and Zimmer, Manuela}, biburl = {https://puma.ub.uni-stuttgart.de/bibtex/2e3eb92c69400082f5cd9246c72a85988/mazimmer}, day = 16, doi = {10.1038/s41598-023-47468-z}, interhash = {ec95c12f71a6a3f8d4c38fb43c5fdaf0}, intrahash = {e3eb92c69400082f5cd9246c72a85988}, issn = {2045-2322}, journal = {Scientific Reports}, keywords = {grk2198 isd myown}, month = nov, number = 1, pages = 20062, timestamp = {2024-02-13T22:12:37.000+0100}, title = {Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography}, url = {https://doi.org/10.1038/s41598-023-47468-z}, volume = 13, year = 2023 }