Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NF$\kappa$B activation caused by continuous IKK$\beta$ phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKK$\beta$ phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets.
%0 Journal Article
%1 Witt2011
%A Witt, Johannes
%A Barisic, Sandra
%A Sawodny, Oliver
%A Ederer, Michael
%A Kulms, Dagmar
%A Sauter, Thomas
%D 2011
%J EURASIP journal on bioinformatics & systems biology
%K 2011 izi kulms sauter
%N 1
%P 3
%R 10.1186/1687-4153-2011-3
%T Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation.
%U https://doi.org/10.1186/1687-4153-2011-3
%V 2011
%X Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NF$\kappa$B activation caused by continuous IKK$\beta$ phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKK$\beta$ phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets.
%Z Witt, JohannesBarisic, SandraSawodny, OliverEderer, MichaelKulms, DagmarSauter, ThomasengGermanyEURASIP J Bioinform Syst Biol. 2011 Jun 17;2011(1):3. doi: 10.1186/1687-4153-2011-3.
%7 2011/09/14
%@ 9783540752097
@article{Witt2011,
abstract = {Stimulation of human epithelial cells with IL-1 (10 ng/ml) + UVB radiation results in sustained NF$\kappa$B activation caused by continuous IKK$\beta$ phosphorylation. We have recently published a strictly reduced ordinary differential equation model elucidating the involved mechanisms. Here, we compare model extensions for low IL-1 doses (0.5 ng/ml), where delayed IKK$\beta$ phosphorylation is observed. The extended model including a positive regulatory element, most likely auto-ubiquitination of TRAF6, reproduces the observed experimental data most convincingly. The extension is shown to be consistent with the original model and contains very sensitive processes which may serve as potential intervention targets.},
added-at = {2023-06-29T13:07:55.000+0200},
annote = {Witt, JohannesBarisic, SandraSawodny, OliverEderer, MichaelKulms, DagmarSauter, ThomasengGermanyEURASIP J Bioinform Syst Biol. 2011 Jun 17;2011(1):3. doi: 10.1186/1687-4153-2011-3.},
author = {Witt, Johannes and Barisic, Sandra and Sawodny, Oliver and Ederer, Michael and Kulms, Dagmar and Sauter, Thomas},
biburl = {https://puma.ub.uni-stuttgart.de/bibtex/240d54da4856f59188505f32030d3146d/fabian},
doi = {10.1186/1687-4153-2011-3},
edition = {2011/09/14},
interhash = {d379f97cd4eeef3fb0d5b3afce25df1a},
intrahash = {40d54da4856f59188505f32030d3146d},
isbn = {9783540752097},
issn = {1687-4153},
journal = {EURASIP journal on bioinformatics {\&} systems biology},
keywords = {2011 izi kulms sauter},
number = 1,
pages = 3,
pmid = {21910922},
timestamp = {2023-06-29T13:07:55.000+0200},
title = {{Modeling time delay in the NFκB signaling pathway following low dose IL-1 stimulation.}},
url = {https://doi.org/10.1186/1687-4153-2011-3},
volume = 2011,
year = 2011
}
